Reliability of Aspiration Biopsy in Thyroid Nodes: Study of 2190 Operated Patients

Radetić, Miljenko; Z, Kralj; Padovan, I

doi:10.1177/030089168407000313

Cited by 18 publications

(8 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It constitutes a serious limitation of this technique since these malignant lesions would go untreated. The incidence of false negative results is as low as 1% to as high as 30% [9, 10]. The false positive rate was 13.3% for neoplastic lesions but none of these lesions were malignant.…”

Section: Discussionmentioning

confidence: 99%

Correlation of Fine Needle Aspiration Cytology with Histopathology in the Diagnosis of Solitary Thyroid Nodule

Gupta

2010

Journal of Thyroid Research

165

133

View full text Add to dashboard Cite

Background. Fine needle aspiration cytology is considered the gold standard diagnostic test for the diagnosis of thyroid nodules. Fine needle aspiration cytology is a cost effective procedure that provides specific diagnosis rapidly with minimal complications. Based on the cytology findings, patients can be followed in cases of benign diagnosis and subjected to surgery in cases of malignant diagnosis thereby decreasing the rate of unnecessary surgery. Purpose of the present study was to correlate the fine needle aspiration cytology findings with histopathology of excised specimens. Material and Methods. This was a prospective study conducted on 75 consecutive patients between January 2003 and December 2005. All patients with clinically diagnosed solitary thyroid nodule who were clinically and biochemically euthyroid were included for study. Patients with multinodular goitre and who were hypothyroid or hyperthyroid were excluded from the study. Results. The sensitivity, specificity, accuracy, false positive rate, false negative rate, positive predictive value, and negative predictive value of FNAC for the diagnosis of neoplastic solitary thyroid nodules were 80%, 86.6%, 13.3%, 20%, 80%, and 86.6%, respectively. Commonest malignancy detected was papillary carcinoma in 12 patients. Conclusions. Fine needle aspiration cytology is a simple, easy to perform, cost effective, and easily repeated procedure for the diagnosis of thyroid cancer. It is recommended as the first line investigation for the diagnosis of solitary thyroid nodule.

show abstract

Section: Discussionmentioning

confidence: 99%

Correlation of Fine Needle Aspiration Cytology with Histopathology in the Diagnosis of Solitary Thyroid Nodule

Gupta

2010

Journal of Thyroid Research

165

133

View full text Add to dashboard Cite

show abstract

“…The false negative results of FNAC constitute a serious limitation of this technique since malignant lesions would go untreated. The prevalence of false negative results of FNAC in some series may be as high as 20-31% [25][26][27], depending on the quality of smears and the experience of the cytologist in interpreting the findings [26][27][28][29]. But another determining factor in the rate of false negative results of FNAC is the number of patients with benign FNAC who undergo surgery [30].…”

Section: Discussionmentioning

confidence: 99%

Prognostic factors and follow-up of patients with differentiated thyroid carcinoma with false negative or nondiagnostic FNAC before surgery. Comparison with a control group

et al. 2011

View full text Add to dashboard Cite

Since the clinical implementation of fine needle aspiration cytology (FNAC) to diagnose thyroid carcinoma, few patients remain misdiagnosed and little is known about their clinical outcomes. An observational retrospective study was carried out to analyse prognostic factors and follow-up of patients with differentiated thyroid carcinoma (DTC) not disclosed by FNAC before surgery, compared to a control group. From October 2003 to July 2010, 308 patients underwent surgery as treatment for nodular goitre and 53 had DTC. Cases were 12 subjects with DTC and benign (n = 7) or nondiagnostic (n = 5) FNAC. Controls were 39 subjects with DTC and suspicious (n = 19) or malignant (n = 20) FNAC. Prognostic factors, recurrence and survival rates were compared. Cases had longer time from FNAC to surgery than the control group (86.8 ± 74.1 vs. 16.4 ± 23.8 weeks; P < 0.001), higher prevalence of follicular carcinoma (33.3 vs. 2.6%; P = 0.009), and of two-time total thyroidectomy (75 vs. 30.8%; P = 0.016). Average follow-up was 42.7 ± 25.3 months (2-86 months). There were no deaths. Disease-free survival for cases was 66.9 ± 5.8 months, and for controls 78.7 ± 3.9 months (P: ns). In patients with DTC, the result of the FNAC performed before surgery was not an independent predictor of recurrences or mortality in the first 7 years of follow-up. Thus, false negative or nondiagnostic FNAC in a patient with DTC does not seem to be a primary prognostic factor, but it may reveal other adverse prognostic factors such as longer time to therapy and higher prevalence of follicular carcinoma that may influence long-term outcomes.

show abstract

“…It constitutes a serious limitation of this technique since these malignant lesions would go untreated. The incidence of false negative results is as low as 1%to as high as 30% [23][24]. The false positive rate was 15% for neoplastic lesions but none of these lesions were malignant.…”

Section: Discussion:-mentioning

confidence: 95%

Study of Correlation of Fine Needle Aspiration Cytology With Histopathology in the Diagnosis of Solitary Thyroid Nodule: Our Experience.

Gull¹,

Nisar²,

Jeelani³

et al. 2017

IJAR

View full text Add to dashboard Cite

Background: Thyroid nodules are common,thyroid cancer is uncommon and the most common way for it to present is as a solitary thyroid nodule. FNAC has high sensitivity in picking up malignancy in thyroid. The main aim of FNAC is to identify nodules that require surgery and those benign nodules that can be observed clinically and decrease the overall thyroidectomy rate in patients with benign diseases. Objective: To Correlate The FNAC Findings With Histopathology So That Rate Of Unnecessary Thyoidectomies In Benign Pathologies Should Be Avoided. Method: This is a prospective analysis of sixty eight consecutive patients of clinically diagnosed solitary thyroid nodule . All patients who were referred to our department were evaluated. Pre-operative FNAC results were compared with final histopathological diagnosis in all 68 patients. Results: 38 cases were diagnosed as colloid nodular goitre and benign cystic lesions by FNAC. 34 of these cases were nonneoplastic lesions, 2 as papillary carcinoma and 2 as follicular adenoma in histopathological examination . 30 cases were diagnosed as neoplastic lesions (follicular neoplasm, hurthle cell lesions, papillary carcinoma, and suspected malignancy) by FNAC. Statistical analysis of neoplastic lesions showed sensitivity, specificity, false positive rate, false negative rate, positive predictive value, and negative predictive value of FNAC to be 85.7%, 85%, 15%, 14.3%, 85.7%, and 85%, respectively .A total of 12 cases of solitary thyroid nodules were diagnosed as having malignant and the most common malignant lesion detected was papillary carcinoma, 8 out of 12 (66.66%). Conclusion:We concluded that FNAC diagnosis of malignancy is highly significant and such patients should be subjected to surgery. A benign FNAC diagnosis should be viewed with caution as false negative results do occur and these patients should be followed up and any clinical suspicion of malignancy even in the presence of benign FNAC requires surgery.

show abstract

Reliability of Aspiration Biopsy in Thyroid Nodes: Study of 2190 Operated Patients

Cited by 18 publications

References 6 publications

Correlation of Fine Needle Aspiration Cytology with Histopathology in the Diagnosis of Solitary Thyroid Nodule

Correlation of Fine Needle Aspiration Cytology with Histopathology in the Diagnosis of Solitary Thyroid Nodule

Prognostic factors and follow-up of patients with differentiated thyroid carcinoma with false negative or nondiagnostic FNAC before surgery. Comparison with a control group

Study of Correlation of Fine Needle Aspiration Cytology With Histopathology in the Diagnosis of Solitary Thyroid Nodule: Our Experience.

Contact Info

Product

Resources

About