Reliability of benign fine needle aspiration cytology of large thyroid nodules

Porterfield, John R.; Grant, Clive S.; Dean, Diana S.; Thompson, Geoffrey B.; Farley, David R.; Richards, Melanie L.; Reading, Carl C.; Charboneau, J. William; Vollrath, Brenda K.; Sebo, Thomas J.

doi:10.1016/j.surg.2008.09.006

Cited by 101 publications

(73 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Factors that increase the risk of thyroid malignancy, such as exposure to neck radiation during childhood, a family history of medullary or papillary carcinoma and ipsilateral paralysis of the vocal cord, are observed in exceptional cases. With respect to nodule size ≥ 4 cm (13,14), in addition to doubts about whether this finding is really associated with a false-negative FNAC result (15,16), today it is rarely observed in nodular thyroid disease. On the other hand, the detection of hot nodules by radioiodine scintigraphy, mitigating the possibility of malignancy, requires systematic examination and only few nodules would qualify as "hot".…”

Section: Discussionmentioning

confidence: 99%

Ultrasonographic characteristics as a criterion for repeat cytology in benign thyroid nodules

Rosário

Purisch

2010

Arq Bras Endocrinol Metab

View full text Add to dashboard Cite

OBJECTIVE: To report the results of repeat fine-needle aspiration cytology (FNAC) in thyroid nodules with an initial benign cytological diagnosis that grow during follow-up and/or present suspicious ultrasonographic characteristics. SUBJECTS AND METHODS: The sample consisted of 456 patients with 895 nodules. FNAC was repeated after 12 to 18 months in the case of nodules with suspicious ultrasonographic characteristics, irrespective of growth, and when the nodules showed significant growth. RESULTS: Among the 895 nodules examined, 102 (11.4%) presented suspicious ultrasonographic characteristics. The second FNAC revealed malignancy in 18 (17.6%) nodules, including 20% (2/10) of those showing growth and 17.4% (16/92) that did not. Seventy-six (9.6%) of 793 nodules without suspicious characteristics presented growth. Only one case (1.3%) of malignancy was diagnosed by repeat FNAC. CONCLUSIONS: The study suggests ultrasonographic characteristics rather than growth as a criterion for repeat FNAC in the case of nodules with an initial benign cytological diagnosis.

show abstract

Section: Discussionmentioning

confidence: 99%

Ultrasonographic characteristics as a criterion for repeat cytology in benign thyroid nodules

Rosário

Purisch

2010

Arq Bras Endocrinol Metab

View full text Add to dashboard Cite

show abstract

“…Palpable thyroid nodules occur in 4-7% of the population [53][54][55][56][57][58], and 19-67% of lesions are found incidentally during ultrasonographic examination [6]. Management of thyroid nodules poses a significant challenge.…”

Section: Current Limitations In Thyroid Cancer Diagnosis -Unmet Clinimentioning

confidence: 99%

Thyroid cancer metabolism: A review

Gill¹

2016

Thyroid Disorders Ther

View full text Add to dashboard Cite

Metabolic dysregulation within the tumor microenvironment (TME) is critical to the process of tumorigenesis in various cancer types. Thyrocyte metabolism in papillary and anaplastic thyroid cancer, however, remains poorly characterized, and studies analyzing the role of multicompartment metabolism in thyrocyte oncogenesis are sparse. We present a review of the current knowledge on cellular metabolism in non-cancerous and cancerous thyroid tissues, focusing on the monocarboxylate transporters MCT1 and MCT4, and on a transporter of the outer mitochondrial membrane TOMM20. Understanding the metabolic phenotype of tumor cells and associated stromal cells in thyroid cancer can have profound implications on the use of biomarker staining in detecting subclinical cancer, imaging as it relates to expression of various transport proteins, and therapeutic interventions that manipulate this dysregulated tumor metabolism to halt tumorigenesis and eradicate the cancer. Future studies are required to confirm the prognostic significance of these biomarkers and their correlation with existing staging schemas such as the AGES, AMES, ATA and MACIS scoring systems.

show abstract

“…Its reliability in thyroid nodules larger than 4 cm in size is still controversial. Diagnostic lobectomy/thyroidectomy has been recommended because of a high rate of false negativity of FNAB in large thyroid nodules in some studies, while many studies have reported that FNAB can be used with reliability in large nodules as well (6)(7)(8)(9)(10)(11)(12)(13)(14)(15). In addition, there are publications showing that the prevalence of thyroid cancer increases as the nodule diameter increases (7,9,10).…”

Section: Introductionmentioning

confidence: 99%

Reliability of fine needle aspiration biopsy in large thyroid nodules

et al. 2017

View full text Add to dashboard Cite

Objective: Fine needle aspiration biopsy provides one of the most important data that determines the treatment algorithm of thyroid nodules. Nevertheless, the reliability of fine needle aspiration biopsy is controversial in large nodules. The aim of this study was to evaluate the adequacy of fine needle aspiration biopsy in thyroid nodules that are four cm or greater. Material and Methods:We retrospectively examined 219 patients files who underwent thyroidectomy for thyroid nodules that were greater than four centimeter between May 2007 and December 2012. Seventy-four patients with hyperthyroidism, and 18 patients without preoperative fine needle aspiration cytology were excluded from the study. Histopathologic results after thyroidectomy were compared with preoperative cytology results, and sensitivity and specificity rates were calculated.Results: False-negativity, sensitivity and specificity rates of fine needle aspiration biopsy of thyroid nodules were found to be 9.7%, 55.5%, and 85%, respectively. Within any nodule of the 127 patients, 28 (22.0%) had thyroid cancer. However, when only nodules of at least 4 cm were evaluated, thyroid cancer was detected in 22 (17.3%) patients. Conclusion:In this study, fine needle aspiration biopsy of large thyroid nodules was found to have a high falsenegativity rate. The limitations of fine-needle aspiration biopsy should be taken into consideration in treatment planning of thyroid nodules larger than four centimeters.Keywords: Fine needle aspiration biopsy, thyroidectomy, thyroid cancer, thyroid nodule ABSTRACT Turk J Surg

show abstract

Reliability of benign fine needle aspiration cytology of large thyroid nodules

Cited by 101 publications

References 12 publications

Ultrasonographic characteristics as a criterion for repeat cytology in benign thyroid nodules

Ultrasonographic characteristics as a criterion for repeat cytology in benign thyroid nodules

Thyroid cancer metabolism: A review

Reliability of fine needle aspiration biopsy in large thyroid nodules

Contact Info

Product

Resources

About