Reliability of Capillary Complete Blood Count in Children With Acute Gastroenteritis

Wielińska-Wiśniewska, Hanna; Nowak, Jan; Dąbrowski, Michał; Szydłowska, Paula; Szczepanik, Mariusz; Cichocka, Katarzyna; Krzyżanowska-Jankowska, Patrycja; Walkowiak, Jarosław

doi:10.3389/fped.2021.715576

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…Pemeriksaan hematologi dapat dilakukan untuk mengevaluasi adanya anemia, hemokonsentrasi, atau jumlah leukosit yang abnormal pada darah [7]. Meskipun hasil pemeriksaan hematologi tidak bersifat spesifik, namun pemeriksaan ini sering diandalkan oleh dokter dalam pengambilan keputusan untuk masuk rumah sakit serta membantu menyingkirkan penyakit tertentu dan kondisi lain yang lebih parah [8]. Sedangkan, pemeriksaan elektrolit dapat dilakukan untuk menilai sejauh mana deplesi cairan dan elektrolit serta pengaruhnya terhadap fungsi ginjal.…”

Section: Pendahuluanunclassified

Profil Elektrolit dan Hematologi Pasien Balita Diare Akut dengan Dehidrasi Ringan-Sedang di RSUD Abdoel Wahab Sjahranie Samarinda

Dahlan,

Aminyoto,

Muhyi

2023

J. Sains Kes.

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Di seluruh dunia, diare berada pada urutan kedua teratas sebagai penyebab mortalitas pada anak di bawah lima tahun (balita). Diare juga menjadi penyebab kematian tertinggi pada balita di Indonesia maupun di Kalimantan Timur. Berbagai komplikasi dapat ditimbulkan oleh diare, seperti dehidrasi, gangguan elektrolit, hingga kematian. Sebagian besar komplikasi tersebut terkait dengan keterlambatan diagnosis serta pemberian terapi yang tidak tepat. Salah satu modalitas yang dapat membantu penegakan diagnosis diare akut pada anak adalah pemeriksaan elektrolit dan hematologi. Penelitian ini bertujuan untuk mendeskripsikan profil elektrolit dan hematologi pasien balita diare akut dengan dehidrasi ringan-sedang di RSUD Abdoel Wahab Sjahranie Samarinda. Penelitian ini menggunakan desain observasional deskriptif dengan pendekatan retrospektif. Data penelitian diperoleh dari rekam medis RSUD Abdoel Wahab Sjahranie Samarinda periode 2019-2021 menggunakan teknik purposive sampling dan diperoleh 102 sampel. Hasil penelitian ini menunjukkan pada pemeriksaan hematologi, nilai rata-rata leukosit, hemoglobin, dan hematokrit masing-masing 12500/µL, 12.04 g/dL, dan 35.91%. Pada pemeriksaan elektrolit, didapatkan nilai rata-rata natrium, kalium, dan klorida masing-masing 135.4 mmol/L, 4.31 mmol/L, dan 106.39 mmol/L. Kesimpulan penelitian ini adalah profil elektrolit dan hematologi pada sebagian besar balita diare akut dengan dehidrasi ringan-sedang berada pada nilai normal serta gangguan elektrolit yang paling sering terjadi adalah hiponatremi, diikuti oleh hipokalemi dan hiperkloremi.

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Section: Pendahuluanunclassified

Profil Elektrolit dan Hematologi Pasien Balita Diare Akut dengan Dehidrasi Ringan-Sedang di RSUD Abdoel Wahab Sjahranie Samarinda

Dahlan,

Aminyoto,

Muhyi

2023

J. Sains Kes.

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“…Blood proportions of immune cells, such as monocytes, lymphocytes, and granulocytes, are tightly regulated in healthy individuals [1]. Deviations from normative immune cell proportions can be used to predict and monitor the progression of many diseases and conditions including chronic inflammation, viral infections, arterial disease, coronary heart disease, gastroenteritis, endocrine disorders, leukemia, and lymphoma [2][3][4][5][6]. Thus, it is critical to accurately measure the proportion of circulating immune cell subtypes for both diagnosis and monitoring of disease progress [7,8].…”

Section: Introductionmentioning

confidence: 99%

Investigating the effects of maltreatment and acute stress on the concordance of blood and DNA methylation methods of estimating immune cell proportions

et al. 2023

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Background Immune cell proportions can be used to detect pathophysiological states and are also critical covariates in genomic analyses. The complete blood count (CBC) is the most common method of immune cell proportion estimation, but immune cell proportions can also be estimated using whole-genome DNA methylation (DNAm). Although the concordance of CBC and DNAm estimations has been validated in various adult and clinical populations, less is known about the concordance of existing estimators among stress-exposed individuals. As early life adversity and acute psychosocial stress have both been associated with unique DNAm alterations, the concordance of CBC and DNAm immune cell proportion needs to be validated in various states of stress. Results We report the correlation and concordance between CBC and DNAm estimates of immune cell proportions using the Illumina EPIC DNAm array within two unique studies: Study 1, a high-risk pediatric cohort of children oversampled for exposure to maltreatment (N = 365, age 8 to 14 years), and Study 2, a sample of young adults who have participated in an acute laboratory stressor with four pre- and post-stress measurements (N = 28, number of observations = 100). Comparing CBC and DNAm proportions across both studies, estimates of neutrophils (r = 0.948, p < 0.001), lymphocytes (r = 0.916, p < 0.001), and eosinophils (r = 0.933, p < 0.001) were highly correlated, while monocyte estimates were moderately correlated (r = 0.766, p < 0.001) and basophil estimates were weakly correlated (r = 0.189, p < 0.001). In Study 1, we observed significant deviations in raw values between the two approaches for some immune cell subtypes; however, the observed differences were not significantly predicted by exposure to child maltreatment. In Study 2, while significant changes in immune cell proportions were observed in response to acute psychosocial stress for both CBC and DNAm estimates, the observed changes were similar for both approaches. Conclusions Although significant differences in immune cell proportion estimates between CBC and DNAm exist, as well as stress-induced changes in immune cell proportions, neither child maltreatment nor acute psychosocial stress alters the concordance of CBC and DNAm estimation methods. These results suggest that the agreement between CBC and DNAm estimators of immune cell proportions is robust to exposure to child maltreatment and acute psychosocial stress.

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Hematology Reference Values in Indonesian Children

Timan

Aryati

2023

Indonesian J. Clin. Pathol. Med. Lab.

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Every clinical laboratory has to establish its reference ranges for every parameter analyzed. These reference values are intervals considered normal in a healthy person's physiological condition. It will be used by the clinician or other health professionals to interpret the laboratory test results of the patient for making diagnostic decisions, monitoring patient therapy, and predicting the prognosis and it is also used in epidemiology studies. A reference range is defined as an interval in which 95% of a reference population’s values fall. It is very crucial to establish reference intervals for the local population as it is sometimes affected by ethnicity, nutrition, food habits, and economic and other local conditions. Hematology is the most common test performed in a clinical laboratory, and the most used parameter by the clinician including pediatricians. There up to now no well-established reference interval for hematological parameters in pediatrics and children in Indonesia. The reference interval used for hematology parameters in Indonesia is based on reference intervals from other countries or the manufacturer of the hematology analyzers used in a particular laboratory. Establishing a population-specific hematology reference interval is very difficult for pediatrics and children, so it is rarely performed. This study aims to compile the results of hematology parameters from Indonesian children to establish an Indonesian reference value for hematology. The method used was compiling data for the hematology parameter intervals based on studies performed in the Indonesian population and presented as 95% confidence intervals. A pediatric reference range for several hematology parameters has been established based on 3 groups of age in Indonesian children.

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Reliability of Capillary Complete Blood Count in Children With Acute Gastroenteritis

Cited by 3 publications

References 21 publications

Profil Elektrolit dan Hematologi Pasien Balita Diare Akut dengan Dehidrasi Ringan-Sedang di RSUD Abdoel Wahab Sjahranie Samarinda

Profil Elektrolit dan Hematologi Pasien Balita Diare Akut dengan Dehidrasi Ringan-Sedang di RSUD Abdoel Wahab Sjahranie Samarinda

Investigating the effects of maltreatment and acute stress on the concordance of blood and DNA methylation methods of estimating immune cell proportions

Hematology Reference Values in Indonesian Children

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