Services from the Continuously Operating Reference Stations (CORS) of the Global Navigation Satellite System (GNSS) provide data and insights to a range of research areas such as physical sciences, engineering, earth and planetary sciences, computer science, and environmental science. Even though these fields are varied, they are all linked through the GNSS operational application. GNSS CORS have historically been deployed for three-dimensional positioning but also for the establishment of local and global reference systems and the measurement of ionospheric and tropospheric errors. In addition to these studies, CORS is uncovering new, emerging scientific applications. These include real-time monitoring of land subsidence via network real-time kinematics (NRTK) or precise point positioning (PPP), structural health monitoring (SHM), earthquake and volcanology monitoring, GNSS reflectometry (GNSS-R) for mapping soil moisture content, precision farming with affordable receivers, and zenith total delay to aid hydrology and meteorology. The flexibility of CORS infrastructure and services has paved the way for new research areas. The aim of this study is to present a curated selection of scientific papers on prevalent topics such as network monitoring, reference frames, and structure monitoring (like dams), along with an evaluation of CORS performance. Concurrently, it reports on the scientific endeavours undertaken by the Geomatics Research Group at the University of Palermo in the realm of GNSS CORS over the past 15 years.