Background: To provide appropriate, sustainable, and tension-free covering during the reconstruction of extensive myelomeningocele defects, plastic surgeons and neurosurgeons must work closely together. Numerous strategies for reconstruction have been documented, including perforator flaps, muscle flaps, and local random flaps. Dorsal intercostal artery perforator (DICAP) based transposition flap is an option that to be used for reconstruction of these large defects.Objective: To study the versatility of DICAP for Reconstruction of large myelomeningocele defects.Patients and Methods: Ten patients with meningomyelocele deformities who had DICAP based transposition flap for closure were included in this research in the period between March 2016 to October 2022. We operated on neonates as a joint procedure with neurosurgeons.Results: We operated on 10 patients as joint procedure with neurosurgery, age range from 24hrs to 7 days (mean 4.3). Defect sizes ranged between 5 x 5 and 8.5 x 6cm (average was 6.4 x 5.6cm). Max flap dimensions was 8 x 6cm from midline to tip of flap (average 7.2 x 5.8). Defects were thoracolumbar in all patients, extending to sacral region in two patients all flaps healed well in place; 2 flaps suffered from partial superficial necrosis at the edges with no need for any surgical intervention.Conclusions: When compared to a random design, DICAP based transposition flaps are more stable and reliable, provide reconstruction of the defect without crossing the dura and skin suture lines, and have reduced donor-site morbidity.