Reliability of measurements of energy expenditure and substrate oxidation using whole‐room indirect calorimetry

Carnero, Elvis Á.; Bock, C.; Corbin, Karen D.; Luyet, Pierre‐Philippe; Smith, Steven R.; Ravussin, Éric

doi:10.1002/oby.23226

Cited by 7 publications

(20 citation statements)

References 19 publications

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“…On the contrary, high accuracy is crucial for combining data sets from multicenter studies in order to minimize the required sample size (for review, see [30]). Variances in 24‐hour EE within individuals (791 kcal) and among individuals (79,758 kcal, after adjusting for FFM) were comparable with variances found by others (within individual, 1843 kcal/d; among individuals, 80,420 kcal/d [27]). Using intraindividual comparisons, we were able to detect a difference of 43 kcal/d in 24‐hour EE between inactive isocaloric and fasting conditions (Figure 4A).…”

Section: Discussionsupporting

confidence: 78%

Validation of energy expenditure and macronutrient oxidation measured by two new whole‐room indirect calorimeters

Dörner

Hägele

Koop

et al. 2022

Obesity

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Objective The aim of this study was to validate two new whole‐room indirfect calorimeters according to Room Indirect Calorimetry Operating and Reporting Standards (RICORS 1.0). Methods For technical validation, 16 propane combustion tests were performed to determine accuracy and precision of energy expenditure (EE) and ventilation rates of oxygen (VO2), carbon dioxide (VCO2), and respiratory exchange ratio (VCO2/VO2). For biological validation, eight participants (mean [SD], age 24.1 [2.5] years; BMI 24.3 [3.1] kg/m2) underwent four 24‐hour protocols under highly standardized conditions: (1) isocaloric sedentary, (2) fasting sedentary, (3) isocaloric active, and (4) fasting active. Reliability (coefficients of variation [CV]) and minimal detectable changes (MDC) were calculated for 24‐hour EE, sleeping metabolic rate (SMR), physical activity energy expenditure (PAEE), thermic effect of food (TEF), and macronutrient oxidation rates. Results Technical validation showed high reliability and recovery rates for VO2 (0.75% and 100.8%, respectively), VCO2 (0.49% and 100.6%), and EE (0.54% and 98.2%). Biological validation revealed CV and MDC for active conditions of 1.4% and 4.3% for 24‐hour EE, 1.7% and 5.9% for SMR, and 30.2% and 38.4% for TEF, as well as 5.8% and 10.5% for PAEE, respectively. Mean CV and MDC for macronutrient oxidation rates were 9.9% and 22.9%, respectively. Conclusions The precision of 24‐hour EE and SMR was high, whereas it was lower for PAEE and poor for TEF.

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Section: Discussionsupporting

confidence: 78%

Validation of energy expenditure and macronutrient oxidation measured by two new whole‐room indirect calorimeters

Dörner

Hägele

Koop

et al. 2022

Obesity

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“…Energy needs for the treatment period (Days 1‐19) were estimated using the following equation, assuming a 20% increased EE on the metabolic ward compared with that in the calorimeters: EI = (EE in calorimeter [average Days −3, −2, −1] × 1.2) − 1000 kcal [17].…”

Section: Methodsmentioning

confidence: 99%

“…Standards for calorimetry operations used in our study are described in Chen et al [16] and calorimetry methods described in Allerton et al [17]. Briefly, 24‐hour EE and related components (SMR: primary end point; secondary end points: resting metabolic rate; basal metabolic rate; thermic effect of food) and substrate oxidation (respiratory exchange ratio [RER]; RER during sleep; RER over a period of 24 hours [RER 24‐h ]; RER during rest, basal RER; oxidation rates [protein, carbohydrate, and fat]) were measured by indirect calorimetry on three consecutive days during the run‐in period (Days −3, −2 and −1: baseline) and at the end of the treatment period (Days 17, 18, and 19: post‐treatment).…”

Section: Methodsmentioning

confidence: 99%

“…The details of the study design were previously reported. Herein, we briefly describe these components and provide details for aspects of the study not reported elsewhere [17].…”

Section: Methodsmentioning

confidence: 99%

“…Energy needs for the outpatient days (Days −7 through −4) were estimated using the following equation (rounded to the nearest 100 kcal) derived from doubly labeled water studies: 24‐hour EE (kcal/d) = 1279 + 18.3(weight, kg) + 2.3(age, y) − 338(sex: 1 = female, 0 = male) [17, 26]. Energy requirements for the first calorimetry day (Day −3) were estimated using the following equation derived from calorimeter studies: 24‐hour EE (kcal/d) = 26.2(FFM, kg ) + 5.2(FM, kg) − 2.32(age, y) − 96(African American) + 546 [27].…”

Section: Methodsmentioning

confidence: 99%

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Glucagon‐like peptide‐1/glucagon receptor agonism associates with reduced metabolic adaptation and higher fat oxidation: A randomized trial

Corbin

Carnero

Tillner

et al. 2023

Obesity

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Objective: This study tested the hypothesis that treatment with the glucagon-like peptide-1/glucagon receptor agonist SAR425899 would lead to a smaller decrease in sleeping metabolic rate (SMR; kilocalories/day) than expected from the loss of lean and fat mass (metabolic adaptation).Methods: This Phase 1b, double-blind, randomized, placebo-controlled study was conducted at two centers in inpatient metabolic wards. Thirty-five healthy males and females with overweight and obesity (age = 36.5 AE 7.1 years) were randomized to a caloriereduced diet (À1000 kcal/d) and escalating doses (0.06-0.2 mg/d) of SAR425899 (n = 17) or placebo (n = 18) for 19 days. SMR was measured by whole-room calorimetry.Results: Both groups lost weight (À3.68 AE 1.37 kg placebo; À4.83 AE 1.44 kg SAR425899). Those treated with SAR425899 lost more weight, fat mass, and fat free mass (p < 0.05) owing to a greater achieved energy deficit than planned. The SAR425899 group had a smaller reduction in body composition-adjusted SMR (p = 0.002) as compared with placebo, but not 24-hour energy expenditure. Fat oxidation and ketogenesis increased in both groups, with significantly greater increases with SAR425899 (p < 0.05).Conclusions: SAR425899 led to reduced selective metabolic adaptation and increased lipid oxidation, which are believed to be beneficial for weight loss and weight-loss maintenance.

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Estimating Energy Requirements

2023

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Reliability of measurements of energy expenditure and substrate oxidation using whole‐room indirect calorimetry

Abstract: O b e s i t y B i o l o g y a n d I n t e g r a t e d P h y s i o l o g y

Cited by 7 publications

References 19 publications

Validation of energy expenditure and macronutrient oxidation measured by two new whole‐room indirect calorimeters

Validation of energy expenditure and macronutrient oxidation measured by two new whole‐room indirect calorimeters

Glucagon‐like peptide‐1/glucagon receptor agonism associates with reduced metabolic adaptation and higher fat oxidation: A randomized trial

Estimating Energy Requirements

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