Reliability of Plasma Von Willebrand Factor Antigen in Prediction of Esophageal Varices in Patients with Liver Cirrhosis

Mahmoud, Hasan Sedeek; Ghweil, Ali A.; Bazeed, Shamardan Ezzeldin S.; Fayed, Hanan Mahmoud; Meguid, Mona Mohamed Abdel

doi:10.4236/ojgas.2015.56010

Cited by 3 publications

(3 citation statements)

References 15 publications

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“…In the present study, the vWF-Ag cut-off value of 475.85 IU/ml could discriminate patients with large varices from patients having small or medium sized varices, with 100% sensitivity and 83.33% specificity (Fig. 3B), in accordance with Mahmoud et al [21], who found that plasma vWF-Ag was an independent predictor for detecting the presence of large EVs with good sensitivity (91.2%) and specificity (85.7%).…”

Section: Discussionsupporting

confidence: 92%

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Von Willebrand factor and esophageal varices in children with chronic liver diseases

El‐Guindi¹,

Adawy²,

Osheba³

et al. 2021

ceh

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Aim of the study:To evaluate the role of plasma level of von Willebrand factor antigen (vWF-Ag) as a possible predictor for the presence of esophageal varices (EVs) in children with chronic liver diseases (CLDs). Material and methods: All patients underwent upper esophagogastroduodenoscopy (EGD) and were categorized as group I (had EVs) and group II (had no EVs). The following patient data were determined: Child-Pugh score (CPS), plasma vWF-Ag, vWF-Ag/thrombocyte ratio (VITRO) score, aspartate transaminase (AST) to platelet ratio index (APRI) score, AST/alanine transaminase (ALT), platelet count/spleen diameter, grading of EVs (small, medium and large) and categorizing the stage of liver fibrosis. Results: The analysis included 50 patients with CLD; 30 (60%) were female. The commonest etiological diagnoses were autoimmune hepatitis (AIH) (20%) and extra-hepatic biliary atresia (EHBA) (12%). 26% of cases were categorized as undiagnosed CLD. The CPS showed CPS-A 34%, CPS-B 44% and CPS-C 22%. The vWF-Ag was found at a high level of 243.52 ±195.97, with a highly statistically significant difference in discriminating the EVs with 74% accuracy at a cut-off value of 108.99 IU/ml, p < 0.0001. Also, ROC analysis was performed for discriminating large esophageal varices with 84% accuracy at a cut-off value of 475.85 mg%. The VITRO score at a cut-off value of 1.72 could detect EVs with 70% sensitivity, 86.7% specificity, and 80% accuracy. Conclusions: High vWF-Ag is a valuable prognostic tool for estimating the presence of EVs, and higher vWF-Ag is associated with increased grade of EVs.

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Section: Discussionsupporting

confidence: 92%

“…3B ), in accordance with Mahmoud et al . [ 21 ], who found that plasma vWF-Ag was an independent predictor for detecting the presence of large EVs with good sensitivity (91.2%) and specificity (85.7%).…”

Section: Discussionmentioning

confidence: 99%

Von Willebrand factor and esophageal varices in children with chronic liver diseases

El‐Guindi¹,

Adawy²,

Osheba³

et al. 2021

ceh

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“…The literature data confirm a correlation between the concentration of vWF and the HVPG values [7,16] suggesting that vWF level reflects the degree of PH. Also, vWF level has been related to some complications of PH such as hepatopulmonary syndrome and esopgaheal varices [89,90].…”

Section: Von-willebrand Factor As An Indicator Of Endothelial Dysfuncmentioning

confidence: 99%

Endothelial Dysfunction and Systemic Inflammation in the Pathogenesis and Progression of Portal Hypertension

Ristovska¹

2021

Portal Hypertension - Recent Advances

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Hepatic and extrahepatic factors contribute to mortality related to liver cirrhosis and therefore much research is still to be done in order to understand the condition thoroughly and to possibly intervene in the process. It is considered that the currently applied prognostic scores are not ideal mortality predictors. On the other hand, recent scientific concepts have revealed the significant contributing role of endothelial dysfunction and of systemic inflammation in the pathogenesis of portal hypertension. Consequently, these concepts are inevitably leading towards proposing and validating new prognostic indicators in cirrhotic patients. Von-Willebrand factor as an indicator of endothelial dysfunction and C-reactive protein as a surrogate marker of systemic inflammation and several other parameters and biological markers have been emerging as a relevant and potentially useful prognostic indicators. Also, the coagulopathy associated to liver disease is in close relation with these entities and still an important research topic. Despite the promising data regarding their prognostic potential, additional research is needed in order to define and validate their value more precisely in clinical and prognostic settings.

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Role of plasma von Willebrand factor antigen in prediction of esophageal varices in pediatric and adolescent patients with portal hypertension

Shazli

Abdelhady

Abdelaziz

2021

Egypt Liver Journal

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Background Ruptured esophageal varices (EVs) are a leading cause of death in Portal hypertension (PHT), it has been a big concern of research to screen EVs through non-invasive approaches. This study aimed to evaluate the role of plasma von Willebrand factor antigen (VWF-Ag) assay for early detection of EVs in patients with portal hypertension. This was a cross-sectional study, done on 47 portal hypertensive children and adolescents who were collected from the Pediatrics Hepatology Clinic, Children Hospital, Ain Shams University. All patients were subjected to comprehensive history taking, thorough clinical examination, routine investigations, abdominal ultrasound, upper GI endoscopy, and measurement of plasma VWF-Ag level. The patients were divided based on their endoscopic findings into two groups; a varices group which included 37 patients, and a non-varices group which included 10 patients. Results VWF-Ag rise significantly in patients with EVs, revealing a direct positive association with the degree of EVs. Conclusion The plasma VWF-Ag can be applied as a non-invasive evidence of the presence and grading of EVs.

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Reliability of Plasma Von Willebrand Factor Antigen in Prediction of Esophageal Varices in Patients with Liver Cirrhosis

Cited by 3 publications

References 15 publications

Von Willebrand factor and esophageal varices in children with chronic liver diseases

Von Willebrand factor and esophageal varices in children with chronic liver diseases

Endothelial Dysfunction and Systemic Inflammation in the Pathogenesis and Progression of Portal Hypertension

Role of plasma von Willebrand factor antigen in prediction of esophageal varices in pediatric and adolescent patients with portal hypertension

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