Reliability of scar assessments performed with an integrated skin testing device – The DermaLab Combo®

Gankande, T.U.; Duke, Janine M.; Danielsen, Patricia L; DeJong, Helen; Wood, Fiona; Wallace, Hilary

doi:10.1016/j.burns.2014.01.025

Cited by 49 publications

(94 citation statements)

References 14 publications

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“…Another limitation of the study was the exclusion of mid-dermal burn injuries treated with autologous cells harvested with the ReCell® device (without SSG) and full-thickness burn injuries treated with Integra® Dermal Regeneration Template (with SSG) due to small numbers of subjects in these categories. The outcome measure used for the study, the height sub-score of a mVSS, is observer-dependent, and use of an objective device for measurement (for example high-frequency ultrasound) would further improve reliability and accuracy of the measurements [31]. …”

Section: Discussionmentioning

confidence: 99%

Identification of factors predicting scar outcome after burn injury in children: a prospective case-control study

et al. 2017

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BackgroundThere is a lack of rigorous research investigating the factors that influence scar outcome in children. Improved clinical decision-making to reduce the health burden due to post-burn scarring in children will be guided by evidence on risk factors and risk stratification. This study aimed to examine the association between selected patient, injury and clinical factors and the development of raised scar after burn injury. Novel patient factors were investigated including selected immunological co-morbidities (asthma, eczema and diabetes type 1 and type 2) and skin pigmentation (Fitzpatrick skin type).MethodsA prospective case-control study was conducted among 186 children who sustained a burn injury in Western Australia. Logistic regression was used to explore the relationship between explanatory variables and a defined outcome measure: scar height measured by a modified Vancouver Scar Scale (mVSS).ResultsThe overall correct prediction rate of the model was 80.6%; 80.9% for children with raised scars (>1 mm) and 80.4% for children without raised scars (≤1 mm). After adjustment for other variables, each 1% increase in % total body surface area (%TBSA) of burn increased the odds of raised scar by 15.8% (95% CI = 4.4–28.5%). Raised scar was also predicted by time to healing of longer than 14 days (OR = 11.621; 95% CI = 3.727–36.234) and multiple surgical procedures (OR = 11.521; 1.994–66.566).ConclusionsGreater burn surface area, time to healing of longer than 14 days, and multiple operations are independently associated with raised scar in children after burn injury. Scar prevention strategies should be targeted to children with these risk factors.

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Section: Discussionmentioning

confidence: 99%

Identification of factors predicting scar outcome after burn injury in children: a prospective case-control study

et al. 2017

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“…1) is based on the principle of narrow-band reflectance spectrophotometry (550 nm AE 30 nm and 660 nm AE 60 nm for haemoglobin [erythema or vascularity] and melanin [pigmentation] respectively). The colour probe specifications has been fully described in our previous publication [8]. The unit displays four readings (three individual measurements and the average of the three measurements) separately for erythema (vascularity) and melanin (pigmentation) using Commission Internationale de l'Eclairage (CIE) -luminance (L), red-green axis (a) and blue-yellow axis (b) [CIELab] values.…”

Section: The Dermalab Combo 1 Device -Colour Probementioning

confidence: 99%

“…Our previous work compared the reliability of subjective scar assessments of the mVSS and objective measurements made with the DermaLab Combo 1 . The results showed that the DermaLab Combo 1 measures pigmentation and vascularity of a scar more reliably than the mVSS [8].…”

Section: Introductionmentioning

confidence: 95%

Interpretation of the DermaLab Combo® pigmentation and vascularity measurements in burn scar assessment: An exploratory analysis

Gankande¹,

Duke²,

Wood³

et al. 2015

Burns

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“…The sensor has optical focusing on a 7‐mm diameter target area, which is small enough for measurements of only the scar, and not surrounding skin, at 35 days after wounding. It uses the principle of narrow‐band reflectance spectrophotometry, with erythema/vascularity measured at 550 ± 30 nm and melanin/pigmentation measured at 660 ± 60 nm …”

Section: Methodsmentioning

confidence: 99%

Thermal injury model in the rabbit ear with quantifiable burn progression and hypertrophic scar

Friedrich

Niknam-Bienia

Xie

et al. 2017

Wound Repair Regeneration

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Hypertrophic scar is a major clinical outcome of deep-partial thickness to full thickness thermal burn injury. Appropriate animal models are a limitation to burn research due to the lack of, or access to, animal models which address the endpoint of hypertrophic scar. Lower species, such as rodents, heal mainly by contracture, which limits the duration of study. Higher species, such as pigs, heal more similarly to humans, but are associated with high cost, long duration for scar development, challenges in quantifying scar hypertrophy, and poor manageability. Here, we present a quantifiable deep-partial thickness burn model in the rabbit ear. Burns were created using a dry-heated brass rod for 10 and 20 seconds at 90 °C. At the time of eschar excision on day 3, excisional wounds were made on the contralateral ear for comparison. Burn wound progression, in which the wound size expands over time is a major distinction between excisional and thermal injuries, was quantified at 1 hour and 3 days after the injuries using calibrated photographs and histology and the size of the wounds was found to be unchanged from the initial wound size at 1 hour, but 10% in the 20 seconds burn wounds at 3 days. A quantifiable hypertrophic scar, measured by histology as the scar elevation index, was present in both 20 seconds burn wounds and excisional wounds at day 35. ImageJ measurements revealed that the 20 seconds burn wound scars were 22% larger than the excisional wound scars and the 20 seconds burn scar area measurements from histology were 26% greater than in the excisional wound scar. The ability to measure both burn progression and scar hypertrophy over a 35-day time frame suits this model to screening early intervention burn wound therapeutics or scar treatments in a burn-specific scar model.

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Reliability of scar assessments performed with an integrated skin testing device – The DermaLab Combo®

Cited by 49 publications

References 14 publications

Identification of factors predicting scar outcome after burn injury in children: a prospective case-control study

Identification of factors predicting scar outcome after burn injury in children: a prospective case-control study

Interpretation of the DermaLab Combo® pigmentation and vascularity measurements in burn scar assessment: An exploratory analysis

Thermal injury model in the rabbit ear with quantifiable burn progression and hypertrophic scar

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