Reliability of Sentinel Lymph Node Mapping With Biopsy for Head and Neck Cutaneous Melanoma

Schmalbach, Cecelia E.; Nussenbaum, Brian; Rees, Riley S.; Schwartz, Jennifer; Johnson, Timothy M.; Bradford, Carol R.

doi:10.1001/archotol.129.1.61

Cited by 91 publications

(103 citation statements)

References 26 publications

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“…After SLNB in the parotid region, no complications were observed. Our experience supports the findings of others that SLNB of intraparotid nodes can be performed safely by experienced surgical oncologists specialized in surgical oncology procedures in the head and neck area without formal parotidectomy [12,13]. The procedure was performed with equivalent safety in the neck and parotid nodal basins.…”

Section: Sentinel Lymph Node Biopsy In Head and Neck Melanoma Is A Chsupporting

confidence: 87%

Does sentinel lymph node biopsy in cutaneous head and neck melanoma alter disease outcome?

Doting

Vries

Plukker

et al. 2006

Journal of Surgical Oncology

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Section: Sentinel Lymph Node Biopsy In Head and Neck Melanoma Is A Chsupporting

confidence: 87%

Does sentinel lymph node biopsy in cutaneous head and neck melanoma alter disease outcome?

Doting

Vries

Plukker

et al. 2006

Journal of Surgical Oncology

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“…A falsenegative SN biopsy rate of 7.9% is not very diVerent compared with studies of head and neck cutaneous melanomas and mucosal squamous cell cancers. Those authors reported the false-negative rates of SN biopsy to be 0-10.5% [6,[14][15][16][17][18][19][20][21][22][23][24][25]. We found 7 SN-positive patients among 45 clinically N0 patients; the upstage rate was 15.6% (7/45).…”

Section: Discussionmentioning

confidence: 46%

“…There are abundant studies of SN biopsy in the trunk, extremities and head and neck. In these studies, the recurrence rate in the prior SN-negative lymphatic basin ranged from 0 to 10.5%; this rate occurred much more frequently in the head and neck than in other regions [16][17][18][19][20][21][22][23][24][25]. Chao et al [17] indicated that the higher false-negative rate of SN biopsy in head and neck cutaneous melanomas was statistically signiWcant.…”

Section: Discussionmentioning

confidence: 97%

Follow-up after intraoperative sentinel node biopsy of N0 neck oral cancer patients

Terada

Hasegawa

Yatabe

et al. 2010

Eur Arch Otorhinolaryngol

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The objective of the study was to evaluate the validity of sentinel node (SN) biopsy in early oral cancer patients focusing on the accuracy of intraoperative diagnoses of SN status, recurrences in follow-up and impact on patient survival. Previously untreated N0 oral cancer patients were candidates for the study. Using a radioisotope method, an intraoperative SN biopsy was performed. Patients with a positive frozen section of SN underwent immediate neck dissection as a single-stage procedure; they were followed in our outpatient clinic. Forty-five cT1-2N0 patients with squamous cell carcinoma were analyzed. There were seven patients with positive SN, five of whom were detected by intraoperative frozen section analysis. The sensitivity, specificity and accuracy of the intraoperative frozen section analysis of SN were 71.4, 100 and 95.6%, respectively. There were 13 recurrences in the course of all patients treated. Those with positive SN showed a tendency toward recurrence. Three patients with negative SN suffered from delayed ipsilateral neck recurrence. These were considered false negatives at a rate of 7.9%. The 5-year overall survival rate of all patients was 91.1%. SN-positive patient survival was significantly poorer than that of SN-negative patients. Positive SN had a negative impact on the survival. SN biopsy was shown to be a valuable method for determining the neck status of early oral cancer patients. The concordance rate of intraoperative multislice frozen section analysis of SN and patient neck status at the time of operation was 95.6%. SN-positive patients exhibited a tendency toward cancer recurrence. There were three cases of false negatives not conforming to the SN concept and their rate was 7.9%. Positive SN had a negative impact on patient survival.

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“…The frequency at which the SLN is recognized in the parotid gland in patients diagnosed with malignant melanoma of the head and neck is 19-44% [2,[7][8][9][10][11]. Further, it is reported that the rate at which a false negative is reported in the SLN in the parotid gland is about 3.1-7%, which is higher compared with other regions [2,3].…”

Section: Discussionmentioning

confidence: 97%

“…On the one hand, there are reports that SLN biopsy of the lymph node of the parotid gland is comparatively safe and the possibility of damage to facial nerves is low [2,8,10]; however, Fincher et al [11] suggest an initial parotidectomy to avoid a high risk of damage to facial nerves in cases in which it is difficult to clearly identify the afferent lymphatic and cases where the SLN frequently occurs in the parotid gland. Moreover, Eicher et al [9] suggest a parotidectomy when the SLN is identified in the parotid gland.…”

Section: Discussionmentioning

confidence: 99%

A false-negative sentinel lymph node in the parotid gland of a melanoma patient: a new algorithm for SLN biopsy in the parotid gland

et al. 2010

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The sentinel lymph node (SLN) is the first node in the lymphatic basin to be affected by metastatic tumor cells from a primary lesion. It provides a way to avoid elective neck dissection in a case in which there is no metastasis to the SLN. However, identification and excision of the SLN may be difficult due to the shine-through phenomenon, as the SLN in the parotid gland is either located close to the primary lesion or, in many cases, the lymph node of the parotid gland is small and covered by fibrous capsula. When we conducted an SLN biopsy on a 68-year-old male patient with malignant melanoma of the cheeks, the metastasis to the node of the parotid gland identified as the SLN was negative; however, 1 year later, the melanoma recurred on the lymph node of the parotid gland, or in other words, we experienced a false-negative SLN. SLN biopsy in the parotid gland is difficult because the lymph node is small and covered by fibrous capsula. We may consider a total or partial resection of the superficial lobe of the parotid gland, particularly when identification of an SLN in the parotid gland is difficult. Therefore, we propose a new algorithm for SLN biopsy in the parotid gland.

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Reliability of Sentinel Lymph Node Mapping With Biopsy for Head and Neck Cutaneous Melanoma

Abstract: Sentinel lymph node mapping with biopsy is a reliable technique to diagnose regional spread from head and neck cutaneous melanoma. This procedure can be performed in both neck and parotid nodal basins with safety and accuracy similar to non-head and neck sites.

Cited by 91 publications

References 26 publications

Does sentinel lymph node biopsy in cutaneous head and neck melanoma alter disease outcome?

Does sentinel lymph node biopsy in cutaneous head and neck melanoma alter disease outcome?

Follow-up after intraoperative sentinel node biopsy of N0 neck oral cancer patients

A false-negative sentinel lymph node in the parotid gland of a melanoma patient: a new algorithm for SLN biopsy in the parotid gland

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