The surgical procedure that lessens edema formation after frenectomy surgery is important.Re-epithelialization with lasers occurs differently from conventional surgery, and this can affect the salivary EGF level. The aim of this study was to determine edema caused by frenectomy surgery and compare the amount of EGF in saliva. Conventional and 810 nm diode laser surgery performed with thirty-four patients. Laser parameters were 400 µm fiber with 2.5 W output energy, in continuous mode.3D face scan data was obtained with a Planmeca Proface Mid device and analyzed with the 3D metrology method using the CloudCompare V2 software. Cephalometric analysis was performed using 2D profile photographs with Geogebra software. Edema measurements were repeated on day 1 (T1), day 3 (T2) and day 14 (T3). All saliva samples were collected at T1 and T3 and salivary EGF concentration was determined using the ELISA method. In conventional surgery, a significant difference was found between ΔT2-T1 and ΔT3-T1 in 3D metrology measurements (p=0.0046). In 2D cephalometric measurements there was significant differences in Angle A T2-T1 vs. Angle A T3-T1 (p=0,0014) and vs. Angle B T2-T1 (p=0,0017) and vs. Angle B T3-T1 (p=0,0087) in conventional surgery. There were no significant changes in edema measurements of laser surgery. The laser frenectomy does not produce edema significantly (p=0,1232). There were no significant changes between groups in salivary EGF measurements (p>0.999). The 810 nm laser surgery produced less edema than conventional surgery. The 810 nm diode laser does not significantly affect salivary EGF.