Reliability of the point-of care analyzer “StatStrip® Xpress™” for measurement of fetal blood lactate

Iorizzo, Linda; Persson, Kristina; Kristensen, Karl; Wiberg, Nana

doi:10.1016/j.cca.2019.04.003

Cited by 3 publications

(5 citation statements)

References 27 publications

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“…The POC CUAV lactate concentration was strongly and significantly correlated with CUAV lactate concentration measured on the reference analyzer ( R 2 = 0.928, F = 1.26 × 10 −56 , Figure 3). Like Iorizzo et al, 17 our POC‐derived values were generally lower than those produced by the reference analyzer. The mean difference between CUAV lactate analyzed at the POC versus the reference analyzer was 0.299 mmol/L (95% CI, 0.220–0.376), which is considered clinically acceptable.…”

Section: Resultssupporting

confidence: 67%

“…The StatStripXpress (SSX; Nova Biomedical, Waltham, MA, USA) was used to assess CUAV lactate concentrations at the POC. Lactate concentrations in UA and UV samples analyzed on the SSX have been shown to correlate closely with those analyzed on reference methods 17 . The present study seeks to determine whether this relationship persists when CUAV samples are used.…”

Section: Methodsmentioning

confidence: 89%

“…Additionally, the use of point‐of‐care (POC) lactate meters, which require a significantly smaller sample and provide results in seconds, 16‐18 could also expedite assessment of neonatal metabolic status. Their use could be particularly beneficial in resource‐constrained settings, as they do not require complex instrumentation or specialized laboratory personnel.…”

Section: Introductionmentioning

confidence: 99%

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Point‐of‐care assessment of combined umbilical arterial and venous lactate: A potential screening test for neonatal acidosis

Yordán

Lewis

McElrath

et al. 2021

Intl J Gynecology & Obste

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Neonatal acidosis, generally defined as an umbilical artery (UA) pH of less than 7.00, 1 has been linked to significant neonatal morbidity, including hypoxic ischemic encephalopathy, intraventricular hemorrhage, cerebral palsy, seizures, and increased rates of neonatal intensive care unit (NICU) admissions and neonatal mortality. [2][3][4][5][6] These associations are thought to be mediated by peripartum hypoxic injury to the fetus, which results in tissue ischemia and increased anaerobic metabolism that is then reflected in a low UA pH at birth.Along with other measures of neonatal well-being, such as APGAR scores, UA pH has been used as a quality indicator among labor wards and as part of the diagnostic and prognostic pathways for neonatal hypoxic-ischemic injury. [1][2][3][4]7,8 However, assessment of pH poses significant limitations if used as a proxy measure for metabolic status. pH is exponentially altered by small changes in respiratory and metabolic function. 9 As such,

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Section: Resultssupporting

confidence: 67%

Section: Methodsmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Point‐of‐care assessment of combined umbilical arterial and venous lactate: A potential screening test for neonatal acidosis

Yordán

Lewis

McElrath

et al. 2021

Intl J Gynecology & Obste

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“…6,10,11 SSLX has been shown to perform with good accuracy and agreement to the stationary blood gas machines. [11][12][13][14][15] It is important to recognise that lactate values vary depending on the POC-lactate-meter used. 1,6 As LP is no longer produced, there is an urgent need for evaluation of a new POC-lactatemeter, with assessment of a safe interventional cutoff to rule out fetal acidosis.…”

Section: Introductionmentioning

confidence: 99%

“…The performance and accuracy in fetal and adult blood for several POC‐lactate‐meters have been published 6,10,11 . SSLX has been shown to perform with good accuracy and agreement to the stationary blood gas machines 11–15 . It is important to recognise that lactate values vary depending on the POC‐lactate‐meter used 1,6 .…”

Section: Introductionmentioning

confidence: 99%

Proposed cutoff for fetal scalp blood lactate in intrapartum fetal surveillance based on neonatal outcomes: a large prospective observational study

Iorizzo

Carlsson

Johansson

et al. 2021

BJOG

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Objective Determination of lactate in fetal scalp blood (FBS) during labour has been recognised since the 1970s. The internationally accepted cutoff of >4.8 mmol/l indicating fetal acidosis is exclusive for the point‐of‐care device (POC) LactatePro™, which is no longer in production. The aim of this study was to establish a new cutoff for scalp lactate based on neonatal outcomes with the use of the StatstripLactate®/StatstripXpress® Lactate system, the only POC designed for hospital use. Design Observational study. Setting January 2016 to March 2020 labouring women with indication for FBS were prospectively included from seven Swedish and one Australian delivery unit. Population Inclusion criteria: singleton pregnancy, vertex presentation, ≥35+0 weeks of gestation. Method Based on the optimal correlation between FBS lactate and cord pH/lactate, only cases with ≤25 minutes from FBS to delivery were included in the final calculations. Main outcome measures Metabolic acidosis in cord blood defined as pH <7.05 plus BDecf >10 mmol/l and/or lactate >10 mmol/l. Results A total of 3334 women were enrolled of whom 799 were delivered within 25 minutes. The areas under the receiver operating characteristics curves (AUC) and corresponding optimal cutoff values were as follows; metabolic acidosis AUC 0.87 (95% CI 0.77–0.97), cutoff 5.7 mmol/l; pH <7.0 AUC 0.83 (95% CI 0.68–0.97), cutoff 4.6 mmol/l; pH <7.05 plus BDecf ≥12 mmol/l AUC 0.97 (95% CI 0.92–1), cutoff 5.8 mmol/l; Apgar score <7 at 5 minutes AUC 0.74 (95% CI 0.63–0.86), cutoff 5.2 mmol/l; and pH <7.10 plus composite neonatal outcome AUC 0.76 (95% CI 0.67–0.85), cutoff 4.8 mmol/l. Conclusion A scalp lactate level <5.2 mmol/l using the StatstripLactate®/StatstripXpress® system will safely rule out fetal metabolic acidosis. Tweetable abstract Scalp blood lactate <5.2 mmol/l using the StatstripLactate®/StatstripXpress system has an excellent ability to rule out fetal acidosis.

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Comparaison de la mesure des lactates au cordon par des appareils portatifs ayant l’habilitation pour une utilisation pendant le travail avec un appareil de référence

Mosnino

Michel

Messedi

et al. 2022

Gynécologie Obstétrique Fertilité & Sénologie

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Reliability of the point-of care analyzer “StatStrip® Xpress™” for measurement of fetal blood lactate

Cited by 3 publications

References 27 publications

Point‐of‐care assessment of combined umbilical arterial and venous lactate: A potential screening test for neonatal acidosis

Point‐of‐care assessment of combined umbilical arterial and venous lactate: A potential screening test for neonatal acidosis

Proposed cutoff for fetal scalp blood lactate in intrapartum fetal surveillance based on neonatal outcomes: a large prospective observational study

Comparaison de la mesure des lactates au cordon par des appareils portatifs ayant l’habilitation pour une utilisation pendant le travail avec un appareil de référence

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