Reliability of three‐dimensional sonographic measurements in early pregnancy using virtual reality

Verwoerd-Dikkeboom, C. M.; Koning, Anton H. J.; Hop, Wim C. J.; Rousian, Melek; Spek, Peter J. van der; Exalto, N.; Steegers, Eric A.P.

doi:10.1002/uog.5390

Cited by 62 publications

(75 citation statements)

References 21 publications

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“…Studies using this VR technology have demonstrated that it provides additional insights, [16][17][18][19][20] especially where structures that need depth for accurate interpretation of size and position are concerned. Verwoerd et al 20 already demonstrated the reliability of this system in measuring standard human embryonic biometry. The volume-measuring tool of V-Scope is a new development.…”

Section: Discussionmentioning

confidence: 99%

“…These data sets were obtained in another study to evaluate embryonic growth and development by Verwoerd et al 20 We used the yolk sac as our object of interest since it is an easy to identify, well-defined, fluid-filled structure. All measurements using the four different techniques were performed off-line (Figure 3) as described in the in vitro part and repeated three times; mean values of these three assessments were used for comparison.…”

Section: In Vivo Studymentioning

confidence: 99%

“…This application has already been successfully applied to 3D prenatal ultrasonography. [16][17][18][19][20] A region-growing segmentation algorithm has been implemented in this program that calculates the volume of selected structures of interest semiautomatically.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Early pregnancy volume measurements: validation of ultrasound techniques and new perspectives

Rousian¹,

Verwoerd-Dikkeboom²,

Koning³

et al. 2008

BJOG

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Objective To investigate accuracy and reliability of four different ultrasound-related volume-measuring methods.Design Observational study.Setting Both in vitro and in vivo.Population or Sample Ten phantoms for in vitro measurements and 28 pregnancies with gestational ages ranging from 6 to 11 weeks for in vivo measurements were included.Methods Three-dimensional (3D) ultrasound images of phantoms (with known variable contents) and yolk sacs were used to calculate volumes using four different methods: Virtual Organ Computed-Aided AnaLysis (VOCAL), inversion mode, Sono Automatic Volume Calculation (SonoAVC) and V-Scope. V-Scope is a newly developed 3D volume visualisation application using a Barco I-Space virtual reality system. Intra-and interobserver agreement was established by calculating intraclass correlation coefficients (ICC).Main outcome measure Evaluation of accuracy and reliability by comparing the different techniques with true volumes (in vitro) and with each other (in vitro and in vivo).Results In the in vitro study, volume measurements by VOCAL, inversion mode and V-Scope proved to be accurate. SonoAVC measurements resulted in a substantial systematic underestimation. Correlation coefficients of measured versus true volumes were excellent in all four techniques. For all techniques, an intra-and interobserver agreement of at least 0.91 was found. Yolk sac measurements by the different techniques proved to be highly correlated (ICCs > 0.91).Conclusions We demonstrated that VOCAL, inversion mode and V-Scope can all be used to measure volumes of hypoechoic structures. The newly introduced V-Scope application proved to be accurate and reliable.

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Section: Discussionmentioning

confidence: 99%

Section: In Vivo Studymentioning

confidence: 99%

See 1 more Smart Citation

Early pregnancy volume measurements: validation of ultrasound techniques and new perspectives

Rousian¹,

Verwoerd-Dikkeboom²,

Koning³

et al. 2008

BJOG

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“…18 High precision was achieved using the means of measurements performed in triplicate. Furthermore, the assessment of long-term RBC folate reflects the periconception maternal folate status.…”

Section: Strengths and Weaknessesmentioning

confidence: 99%

An optimal periconception maternal folate status for embryonic size: the Rotterdam Predict study

Uitert

Ginkel

Willemsen³

et al. 2014

BJOG

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MethodsWe recruited women before 8 weeks of gestation and performed weekly three-dimensional ultrasound scans from enrolment up to 13 weeks of gestation. As a measure of embryonic growth, crown-rump length (CRL) measurements were performed using V-Scope software in the BARCO I-Space. Maternal blood was collected to determine first-trimester long-term red blood cell (RBC) folate status. Non-malformed live births were included in the analysis. We calculated quartiles of RBC folate, square root-transformed CRL data and performed multivariable linear mixed model analyses. Conclusions This study suggests that a very high maternal periconception folate status is associated with reduced embryonic size. Whether these effects are beneficial or harmful requires further investigation.

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“…9 In a research setting, the 3D_VR_US has already been successfully applied for determining various firsttrimester reference values, and in individual cases of complex congenital malformations, 3D_VR_US supported the diagnosis by adding clinically relevant details. [10][11][12][13][14][15][16] Although clinicians rapidly adopted conventional 3D_US upon its introduction at the end of the 1990s without formal evaluation, 7 this study aims to provide diagnostic evidence to support a similar decision on 3D_VR_US. The application is investigated for the use of first-trimester screening for structural abnormalities.…”

Section: Introductionmentioning

confidence: 99%

First-Trimester Detection of Surface Abnormalities: A Comparison of 2- and 3-Dimensional Ultrasound and 3-Dimensional Virtual Reality Ultrasound

et al. 2014

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The aim was to determine the diagnostic performance of 3-dimensional virtual reality ultrasound (3D_VR_US) and conventional 2-and 3-dimensional ultrasound (2D/3D_US) for first-trimester detection of structural abnormalities. Forty-eight first trimester cases (gold standard available, 22 normal, 26 abnormal) were evaluated offline using both techniques by 5 experienced, blinded sonographers. In each case, we analyzed whether each organ category was correctly indicated as normal or abnormal and whether the specific diagnosis was correctly made. Sensitivity in terms of normal or abnormal was comparable for both techniques (P ¼ .24). The general sensitivity for specific diagnoses was 62.6% using 3D_VR_US and 52.2% using 2D/3D_US (P ¼ .075). The 3D_VR_US more often correctly diagnosed skeleton/limb malformations (36.7% vs 10%; P ¼ .013). Mean evaluation time in 3D_VR_US was 4:24 minutes and in 2D/3D_US 2:53 minutes (P < .001). General diagnostic performance of 3D_VR_US and 2D/3D_US apparently is comparable. Malformations of skeleton and limbs are more often detected using 3D_VR_US. Evaluation time is longer in 3D_VR_US.

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Reliability of three‐dimensional sonographic measurements in early pregnancy using virtual reality

Abstract: Objective To establish the reliability of three-dimensional (3D) ultrasound measurements in early pregnancy using a virtual reality system (the Barco I-Space). MethodsThe study included 28 pregnancies with gestational ages ranging from 6 to 14 (median, 10)

Cited by 62 publications

References 21 publications

Early pregnancy volume measurements: validation of ultrasound techniques and new perspectives

Early pregnancy volume measurements: validation of ultrasound techniques and new perspectives

An optimal periconception maternal folate status for embryonic size: the Rotterdam Predict study

First-Trimester Detection of Surface Abnormalities: A Comparison of 2- and 3-Dimensional Ultrasound and 3-Dimensional Virtual Reality Ultrasound

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