Reliability of vessel diameter measurements with a retinal oximeter

Blondal, Renata; Sturludottir, Margret Kara; Hardarson, Sveinn Hákon; Halldorsson, Gisli H.; Stefánsson, Einar

doi:10.1007/s00417-011-1680-2

Cited by 50 publications

(56 citation statements)

References 48 publications

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“…Both retinal arterioles and venules inferior and superior to the optic nerve head were measured. Only retinal vessels with a width of more than six pixels, which equals approximately 56 micrometers,10 and a length between 50 and 200 pixels were analysed. Around the optic disc, an area of 15 pixels as well as branching vessels and their origin were manually excluded.…”

Section: Methodsmentioning

confidence: 99%

Retinal oxygen metabolism in healthy subjects and glaucoma patients

et al. 2014

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Section: Methodsmentioning

confidence: 99%

Retinal oxygen metabolism in healthy subjects and glaucoma patients

et al. 2014

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“…So a reduced retinal vasculature may indicate persistent subclinical hypoxia of the retina [54,55]. It would be interesting to determine the oxygen saturation of the retina at the NR stage of PDR subjects versus NR subjects [56,57] and this may be the focus of a future study. Neuronal degeneration and visual functions are affected before the onset of DR [58,59].…”

Section: Discussionmentioning

confidence: 99%

Retinal Vascular Calibre, Geometry and Progression of Diabetic Retinopathy in Type 2 Diabetes Mellitus

2012

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Purpose: To determine whether changes in retinal vascular calibre and geometry are associated with progression of diabetic retinopathy in type 2 diabetes (T2D). Procedures: The retinal vascular calibre and geometry of 30 subjects with more than 20 years of diagnosed T2D with no retinopathy (NR) were compared to 30 subjects that progressed to proliferative diabetic retinopathy (PDR). The images of PDR subjects included in this study were those obtained before the onset of retinopathy. The diameter of retinal arterioles (CRAE), retinal venules (CRVE), tortuosity of retinal vessels, junctional exponent deviation (JE_a) and fractal dimension (D_f) were measured using Singapore I Vessel Assessment (SIVA 3.0) software and compared using Mann-Whitney U test. Results: The median CRAE and the median CRVE were significantly wider in PDR subjects compared to NR subjects (p = 0.014 and 0.016), respectively. Curvature tortuosity of the retinal arteries and veins and D_f were significantly decreased in the PDR subjects compared to NR subjects (p = 0.015, 0.016 and 0.03, respectively). The JE_a was significantly increased in PDR subjects (p = 0.01). Conclusions: Retinal vessel calibre and geometry of the retinal vasculature may be important risk factors for the progression to PDR. More longitudinal prospective studies will be needed to further explore the findings of this study.

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“…12 The Oxymap T1 Retinal Oximeter (Oxymap, Reykjavik, Iceland) is specifically designed to be mounted on a Topcon TRC50-VT fundus camera (Topcon, Tokyo, Japan). 13 Studies have shown that this device is capable of producing repeatable 14 and reliable measurements when detecting differences in SO 2 levels between healthy and diseased eyes. 15,16 A recent study 17 reported normative values of SO 2 from a population that included only Icelandic Caucasians.…”

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confidence: 99%