“…In clinical studies, peripheral edema, as a pharmacologically-mediated adverse event, has typically been captured through water-displacement volumetry, patient self-report, or other, often non-validated, investigator assessments. [20][21][22][23][24][25] Water-displacement volumetry is widely considered to be the reference method of edema assessment; 26 however, it is also considered to be time-consuming, difficult to perform, and inappropriate in some clinical situations (e.g., postoperative), limiting the use of this method. 12,27 Documentation of the accuracy and reliability of other methods of measuring peripheral edema vary.…”