Reliable and fast volumetry of the lumbar spinal cord using cord image analyser (Cordial)

Tsagkas, Charidimos; Altermatt, A.; Bonati, Leo H.; Pezold, Simon; Reinhard, Julia; Amann, Michael; Cattin, Philippe C.; Wuerfel, Jens; Fischer, Dirk; Parmar, Katrin; Fischmann, Arne

doi:10.1007/s00330-018-5431-1

Cited by 2 publications

(3 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Segmental nerve rootlets would provide a proper identification of the spinal segments, it is however difficult to identify and requires high resolution T2w scans and an expert rater to identify them. A few studies have attempted to bypass the vertebral-based limitation using the distance from an anatomical landmark, such as the pontomedullary junction (PMJ) (Stroman et al, 2008 ; Cadotte et al, 2015 ; Amann et al, 2016 ), and the conus medullaris (Tsagkas et al, 2018 ). However, these methods require manual intervention limiting large-scale applications.…”

Section: Introductionmentioning

confidence: 99%

“…However, these methods require manual intervention limiting large-scale applications. In addition, the PMJ was not used in the context of measuring SC CSA (Stroman et al, 2008 ; Cadotte et al, 2015 ; Amann et al, 2016 ; Tsagkas et al, 2018 ). For cervical SC measures, the PMJ is a more appropriate landmark due to its proximity to the cervical SC, hence limiting the required field of view in MRI scans, compared to conus medullaris which could be more appropriate for lumbar SC measures.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Automatic measure and normalization of spinal cord cross-sectional area using the pontomedullary junction

Bédard

Cohen‐Adad²

2022

Front. Neuroimaging

View full text Add to dashboard Cite

Spinal cord cross-sectional area (CSA) is a relevant biomarker to assess spinal cord atrophy in neurodegenerative diseases. However, the considerable inter-subject variability among healthy participants currently limits its usage. Previous studies explored factors contributing to the variability, yet the normalization models required manual intervention and used vertebral levels as a reference, which is an imprecise prediction of the spinal levels. In this study we implemented a method to measure CSA automatically from a spatial reference based on the central nervous system (the pontomedullary junction, PMJ), we investigated factors to explain variability, and developed normalization strategies on a large cohort (N = 804). Following automatic spinal cord segmentation, vertebral labeling and PMJ labeling, the spinal cord CSA was computed on T1w MRI scans from the UK Biobank database. The CSA was computed using two methods. For the first method, the CSA was computed at the level of the C2–C3 intervertebral disc. For the second method, the CSA was computed at 64 mm caudally from the PMJ, this distance corresponding to the average distance between the PMJ and the C2–C3 disc across all participants. The effect of various demographic and anatomical factors was explored, and a stepwise regression found significant predictors; the coefficients of the best fit model were used to normalize CSA. CSA measured at C2–C3 disc and using the PMJ differed significantly (paired t-test, p-value = 0.0002). The best normalization model included thalamus, brain volume, sex and the interaction between brain volume and sex. The coefficient of variation went down for PMJ CSA from 10.09 (without normalization) to 8.59%, a reduction of 14.85%. For CSA at C2–C3, it went down from 9.96 to 8.42%, a reduction of 15.13 %. This study introduces an end-to-end automatic pipeline to measure and normalize cord CSA from a neurological reference. This approach requires further validation to assess atrophy in longitudinal studies. The inter-subject variability of CSA can be partly accounted for by demographics and anatomical factors.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Automatic measure and normalization of spinal cord cross-sectional area using the pontomedullary junction

Bédard

Cohen‐Adad²

2022

Front. Neuroimaging

View full text Add to dashboard Cite

show abstract

“…A few have introduced surrogate neuroanatomic landmarks to overcome the limitation of the vertebral reference like the pontomedullary junction (PMJ) 7 , 11 or the conus medullaris 12 .…”

Section: Introductionmentioning

confidence: 99%

Pontomedullary junction as a reference for spinal cord cross-sectional area: validation across neck positions

Bédard,

Bouthillier,

Cohen-Adad

2023

Sci Rep

View full text Add to dashboard Cite

Spinal cord cross-sectional area (CSA) is an important MRI biomarker to assess spinal cord atrophy in various neurodegenerative and traumatic spinal cord diseases. However, the conventional method of computing CSA based on vertebral levels is inherently flawed, as the prediction of spinal levels from vertebral levels lacks reliability, leading to considerable variability in CSA measurements. Computing CSA from an intrinsic neuroanatomical reference, the pontomedullary junction (PMJ), has been proposed in previous work to overcome limitations associated with using a vertebral reference. However, the validation of this alternative approach, along with its variability across and within participants under variable neck extensions, remains unexplored. The goal of this study was to determine if the variability of CSA across neck flexions/extensions is reduced when using the PMJ, compared to vertebral levels. Ten participants underwent a 3T MRI T2w isotropic scan at 0.6 mm3 for 3 neck positions: extension, neutral and flexion. Spinal cord segmentation, vertebral labeling, PMJ labeling, and CSA were computed automatically while spinal segments were labeled manually. Mean coefficient of variation for CSA across neck positions was 3.99 ± 2.96% for the PMJ method vs. 4.02 ± 3.01% for manual spinal segment method vs. 4.46 ± 3.10% for the disc method. These differences were not statistically significant. The PMJ method was slightly more reliable than the disc-based method to compute CSA at specific spinal segments, although the difference was not statistically significant. This suggests that the PMJ can serve as a valuable alternative and reliable method for estimating CSA when a disc-based approach is challenging or not feasible, such as in cases involving fused discs in individuals with spinal cord injuries.

show abstract

Reliable and fast volumetry of the lumbar spinal cord using cord image analyser (Cordial)

Cited by 2 publications

References 22 publications

Automatic measure and normalization of spinal cord cross-sectional area using the pontomedullary junction

Automatic measure and normalization of spinal cord cross-sectional area using the pontomedullary junction

Pontomedullary junction as a reference for spinal cord cross-sectional area: validation across neck positions

Contact Info

Product

Resources

About