Reliable surface modification of dental plastic substrates to reduce biofouling with a photoreactive phospholipid polymer

Ishihara, Kazuhíko; Fukazawa, Kyoko; Inoue, Yasuo; Koyama, Jun; Mori, Yoshiyuki; Kinoshita, Toru; Hiranuma, K.; Yasuda, Noboru

doi:10.1002/app.46512

Cited by 7 publications

(7 citation statements)

References 42 publications

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“…Ionic phosphodiester‐based materials tend to show excellent cellular compatibility, hemocompatibility and a resistance to adsorption of proteins . Adsorption of proteins can induce an inflammatory foreign‐body response so this adverse response will be much reduced in the case of phosphodiester‐coated surfaces .…”

Section: Introductionmentioning

confidence: 99%

Phosphodiester Hydrogels for Cell Scaffolding and Drug Release Applications

Dera

Diliën

Billen

et al. 2019

Macromolecular Bioscience

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Given the major structural role phosphodiesters play in the organism it is surprising they have not been more widely adopted as a building block in sophisticated biomimetic hydrogels and other biomaterials. The potential benefits are substantial: phosphoester‐based materials show excellent compatibility with blood, cells, and a remarkable resistance to protein adsorption that may trigger a foreign‐body response. In this work, a novel class of phosphodiester‐based ionic hydrogels is presented which are crosslinked via a phosphodiester moiety. The material shows good compatibility with blood, supports the growth and proliferation of tissue and presents opportunities for use as a drug release matrix as shown with fluorescent model compounds. The final gel is produced via base‐induced elimination from a phosphotriester precursor, which is made by the free‐radical polymerization of a phosphotriester crosslinker. This crosslinker is easily synthesized via multigram one‐pot procedures out of common laboratory chemicals. Via the addition of various comonomers the properties of the final gel may be tuned leading to a wide range of novel applications for this exciting class of materials.

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Section: Introductionmentioning

confidence: 99%

Phosphodiester Hydrogels for Cell Scaffolding and Drug Release Applications

Dera

Diliën

Billen

et al. 2019

Macromolecular Bioscience

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“…Control of composition is difficult. Since PEEK absorbs ultraviolet irradiation, it was used for chemical surface modification and grafting [18][19][20]. Due to the high-energy treatments, a high diversity of different functional groups are formed on the surface, but the effect is usually not permanent [21,22].…”

Section: Introductionmentioning

confidence: 99%

Selective Grafting of Polyamines to Polyether Ether Ketone Surface during Molding and Its Use for Chemical Plating

et al. 2018

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We present a new approach of surface functionalization of polyether ether ketone (PEEK) that is carried out during the molding step. Thin films of polymers with different functional groups were applied to the surface of a mold and brought in close contact with a PEEK melt during injection molding. The surfaces of the produced parts were characterized after solidification. Only those PEEK surfaces that were in contact with polymers bearing primary amino groups exhibited a wettability for water. Obviously, the thin polymer film was grafted to the surface by a chemical reaction initiated by the high melt temperature. The formation of azomethine bonds between PEEK and the polyamine by coupling to the ketone groups was proposed. The other amino groups in the molecule were still in function after the molding process. They adsorbed different anionic molecules and anionic charged nanoparticles from aqueous solutions. The surfaces could be chemically plated by copper and nickel with high adhesion.

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“…Two main strategies have been used to prevent implant-related infection: (1) minimizing the bacterial attachment or (2) killing bacteria present on the surface of the implant. In the first category, Ishihari et al grafted a coating of poly(2-methacryloyloxyethyl phosphorylcholine) (PMPC), a highly hydrophilic polymer, onto the surface of PEEK via photo-induced graft polymerization of MPC [11] or via aryl-azide UV photoinsertion of PMPC [12]. It was found that the increased surface wettability of PEEK-PMPC (< 10° for PEEK-PMPC compared to 90° for untreated PEEK) offered a certain degree of protection in vitro against E. coli adhesion [13].…”

Section: Introductionmentioning

confidence: 99%

Synergistic anti-fouling and bactericidal poly(ether ether ketone) surfaces via a one-step photomodification

Buwalda

Rotman

Eglin

et al. 2020

Materials Science and Engineering: C

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Implants of poly(ether ether ketone) (PEEK) are gaining importance in surgical bone reconstruction of the skull. As with any implant material, PEEK is susceptible to bacterial contamination and occasionally PEEK implants were removed from patients because of infection.To address this problem, a combination of anti-fouling and bactericidal polymers are grafted onto PEEK. The originality is that anti-fouling (modified poly(ethylene glycol)) and bactericidal (quaternized poly(dimethylaminoethyl acrylate)) moieties are simultaneously and covalently grafted onto PEEK via UV photoinsertion. The functionalized PEEK surfaces are evaluated by water contact angle measurements, FTIR, XPS and AFM. Grafting of anti-fouling and bactericidal polymers significantly reduces Staphylococcus aureus adhesion on PEEK surfaces without exhibiting cytotoxicity in vitro. This study demonstrates that grafting combinations of anti-fouling and bactericidal polymers synergistically prevents bacterial adhesion on PEEK implants. This approach shows clinical relevance as grafting is rapid, does not modify PEEK properties and can be conducted on pre-formed implants.

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Reliable surface modification of dental plastic substrates to reduce biofouling with a photoreactive phospholipid polymer

Cited by 7 publications

References 42 publications

Phosphodiester Hydrogels for Cell Scaffolding and Drug Release Applications

Phosphodiester Hydrogels for Cell Scaffolding and Drug Release Applications

Selective Grafting of Polyamines to Polyether Ether Ketone Surface during Molding and Its Use for Chemical Plating

Synergistic anti-fouling and bactericidal poly(ether ether ketone) surfaces via a one-step photomodification

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