Currently, the deficiencies of the 5G mobile system as an enabler of Internet of Everything (IoE) applications are stimulating global research activities to focus on the sixth generation (6G) wireless system. The potential of IoE is enormous and growing exponentially. With the dawn of the fifth industrial revolution, IoE is transposing into industrial Internet of Everything (IIoE) projects which are complex and are eventuating to become a prominent technology for all industries offering new opportunities. This study embodies a synthesis of 6G, IoT, IoE, IIoE exhaustive literature review advancing knowledge to facilitate theory development. For the first time, a novel theoretical framework for the 6G-enabled IIoE (henceforth referred to as 6GIIoE) system was developed. Judiciously, sequential methodology is best suited for this emerging discipline research to create significant new knowledge in the literature contributing eternal insights to expound valuable contexts to ruminate significant findings. The theoretical framework developed recognizes 6GIIoE priority areas, challenges, and applications bestowing a guide for 6G-enabled IIoE initiatives divulging opportunities for future research activities.