Relief of Intractable Posthypoxic Myoclonus After Administration of Agomelatine

Aleja, Jesús González de la; Saiz-Díaz, Rosa Ana; Peña, Pilar de la

doi:10.1097/wnf.0b013e3182613e06

Cited by 8 publications

(8 citation statements)

References 10 publications

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“…The precise anti-myoclonus mechanism of these agents is unknown, but this likely relates to the suppression of excessive neuronal firing within the neuronal circuits that generate the cortical myoclonus. Some reports have documented the usefulness of lacosamide and agomelatine in treating posthypoxic myoclonus [41][42][43]. Zonisamide has demonstrated effectiveness as adjunctive therapy for treating myoclonus in patients with Unverricht-Lundborg disease and Lafora body disease [44,45].…”

Section: Treatmentmentioning

confidence: 99%

Physiology-Based Treatment of Myoclonus

Pena

Caviness

2020

Neurotherapeutics

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Myoclonus can cause significant disability for patients. Myoclonus has a strikingly diverse array of underlying etiologies, clinical presentations, and pathophysiological mechanisms. Treatment of myoclonus is vital to improving the quality of life of patients with these disorders. The optimal treatment strategy for myoclonus is best determined based upon careful evaluation and consideration of the underlying etiology and neurophysiological classification. Electrophysiological testing including EEG (electroencephalogram) and EMG (electromyogram) data is helpful in determining the neurophysiological classification of myoclonus. The neurophysiological subtypes of myoclonus include cortical, cortical-subcortical, subcortical-nonsegmental, segmental, and peripheral. Levetiracetam, valproic acid, and clonazepam are often used to treat cortical myoclonus. In cortical-subcortical myoclonus, treatment of myoclonic seizures is prioritized, valproic acid being the mainstay of therapy. Subcortical-nonsegmental myoclonus may be treated with clonazepam, though numerous agents have been used depending on the etiology. Segmental and peripheral myoclonus are often resistant to treatment, but anticonvulsants and botulinum toxin injections may be of utility depending upon the case. Pharmacological treatments are often hampered by scarce evidence-based knowledge, adverse effects, and variable efficacy of medications.

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Section: Treatmentmentioning

confidence: 99%

Physiology-Based Treatment of Myoclonus

Pena

Caviness

2020

Neurotherapeutics

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“… EEG event 26 ms prior to the myoclonus. NA NA González de la Aleja et al 58 Generalized spike and slow wave complexes with mild background slowing. EEG–EMG simultaneous recording revealed a time locked cortical discharge preceding myoclonus and myoclonus without a correlated EEG.…”

Section: Methodsmentioning

confidence: 99%

“… 34 Some reports have mentioned the usefulness of lacosamide, 55 sodium oxybate, 56 zonisamide, 57 and agomelatine. 58 …”

Section: Methodsmentioning

confidence: 99%

Post-hypoxic Myoclonus: Current Concepts, Neurophysiology, and Treatment

Gupta

Caviness

2016

Tremor and Other Hyperkinetic Movements

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“…18 Lacosamide, zonisamide, sodium oxybate and agomelatine have also been deemed to be beneficial in LAS. [29][30][31][32]…”

Section: Treatmentmentioning

confidence: 99%

Post-hypoxic myoclonus; what we know and gaps in knowledge

Ahmed

2023

Trop Doct

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Post-hypoxic myoclonus (PHM) is a rare neurological complication having two different variants depending on acute or chronic onset after cardiopulmonary resuscitation following cardiac arrest: myoclonic status epilepticus (MSE) and Lance–Adams syndrome (LAS) respectively. Clinical and simultaneous electro-encephalographic (EEG) and electromyographic (EMG) tracing can distinguish between the two. Anecdotal treatment with benzodiazepines and anaesthetics (in the case of MSE) have been tried. Although limited evidence is available, valproic acid, clonazepam and levetiracetam, either in combination with other drugs or alone, have shown to control epilepsy associated with LAS effectively. Deep brain stimulation is a novel and promising advance in LAS treatment.

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Relief of Intractable Posthypoxic Myoclonus After Administration of Agomelatine

Cited by 8 publications

References 10 publications

Physiology-Based Treatment of Myoclonus

Physiology-Based Treatment of Myoclonus

Post-hypoxic Myoclonus: Current Concepts, Neurophysiology, and Treatment

Post-hypoxic myoclonus; what we know and gaps in knowledge

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