Relief of pruritus in patients with atopic dermatitis after treatment with topical doxepin cream

Drake, Lynn A.; Fallon, Jerome D.; Sober, Arthur J.

doi:10.1016/s0190-9622(94)70225-x

Cited by 179 publications

(66 citation statements)

References 5 publications

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“…Doxepin is an oral tricyclic antidepressant, which has also been manufactured as a topical 5 % cream and has been used successfully in patients with atopic dermatitis. It has anti-H 1 and anti-H 2 properties and is also thought to have some antimuscarinic effects (Drake et al 1994). Doxepin is beneficial in patients with lichen simplex chronicus, nummular dermatitis and contact dermatitis (Patel and Yosipovitch 2010) but is ineffective in other conditions that cause itching (Yosipovitch and Bernhard 2013).…”

Section: Topical Antihistaminesmentioning

confidence: 99%

Current Topical and Systemic Therapies for Itch

Leslie

Greaves

Yosipovitch

2015

Handbook of Experimental Pharmacology

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Itch is a common distressing symptom which may be caused by multifactorial aetiologies including inflammatory skin diseases, systemic diseases, neuropathic conditions and psychogenic disorders. Itch is a term used synonymously with pruritus and is defined as acute if it lasts less than 6 weeks or chronic if it persists for more than 6 weeks. It can have the same impact on the quality of life as chronic pain and shares many of the same pathophysiological pathways. Depending on the aetiology of the itch, different pathogenic mechanisms have been postulated with a number of mediators identified. These include histamine, leukotrienes, proteases, neuropeptides, cytokines and opioids, which may activate peripheral itch-mediating C-fibres via receptors on the nerve terminals and central neuronal pathways. Therefore, there is no single universally effective anti-itch treatment available. First-line treatments for itch include topical therapies, such as emollients, mild cleansers (low pH), topical anaesthetics, steroids, calcineurin inhibitors and coolants (menthol). Treatment with systemic therapies can vary according to the aetiology of the chronic itch. Non-sedating antihistamines are helpful in conditions such as urticaria where the itch is primarily histamine mediated. Although the itch of eczema is not mediated by histamine, sedating antihistamines at night are helpful to break the itch-scratch cycle. Chronic itch may also be treated with other systemic therapies, such as anticonvulsants, antidepressants as well as mu-opioid antagonists, kappa-opioid agonists and phototherapy, depending on the cause of the itch. This article summarises the topical and systemic therapies available with our current understanding of the pathophysiology of itch.

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Section: Topical Antihistaminesmentioning

confidence: 99%

Current Topical and Systemic Therapies for Itch

Leslie

Greaves

Yosipovitch

2015

Handbook of Experimental Pharmacology

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“…In a double-blind study, oral doxepin was significantly more effective and less sedative than diphenhydramine [58-73-1] in the treatment of chronic urticaria. When tested topically, doxepin was more effective than placebo in reducing pruritus in patients with atopic dermatitis [20]. Thus, compounds in this class may possibly prove useful for controlling allergic skin reactions.…”

Section: Anti-inflammatory Agentsmentioning

confidence: 99%

Dermatotherapeutic Agents

Gendimenico

2015

Ullmann's Encyclopedia of Industrial Chemistry

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“…It also possesses antiserotonin and adren ergic modulating activity. One double-blind, vehicle-controlled multicentre study of 270 patients with atopic dermatitis showed relief in 85% of doxepin-treated patients and 57% of vehicle-treated patients after 7 days' appli cation [11], Drowsiness, due to percutaneous absorption, was a common side effect, as well as local irritancy. Although this new product seems a fairly safe and effective antipruritic, the extent to which its effectiveness is due to a systemic rather than a local action is unclear.…”

Section: Greavesmentioning

confidence: 99%

Anti-Itch Treatments: Do They Work?

Greaves¹

1997

Skin Pharmacol Physiol

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Relief of pruritus in patients with atopic dermatitis after treatment with topical doxepin cream

Cited by 179 publications

References 5 publications

Current Topical and Systemic Therapies for Itch

Current Topical and Systemic Therapies for Itch

Dermatotherapeutic Agents

Anti-Itch Treatments: Do They Work?

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