Context: This research article is about the role of educational teachings of religion in the prevention of high-risk social behaviors, based on Imam Sadeq's (peace be upon him) biography and Hadiths considering the relationship between religion and high-risk behaviors. Evidence Acquisition: In this research, using descriptive-analytical method, on one hand, the relationship between religion and high-risk behaviors in published articles, especially PubMed, has been considered and, on the other hand, by reviewing about twenty thousand narratives of biography and Hadiths of Imam Sadiq (peace be upon him), the most important examples of high-risk behaviors referred by him are discussed. Results: This survey emphasized the acquisition of religious teachings, the study and consideration on religion, familiarity with God, necessity of marriage, halal occupation, moderate behavior, meeting with friends and strengthening them, attention to food, planning, indirect notification, and appropriate punishment are some of the most important preventive educational teachings of high-risk behaviors in the speech and behavior of Imam Sadiq (peace be upon him), which have been confirmed in various internal and external research. Conclusions: The educational teachings of religion can make it possible for people in the society to tend less to exhibit social harms and, consequently, high-risk behavior, ensuring health for the individual, family, and finally, the society by establishing a constructive meanwhile, preventive role in everybody.