Over the period in which the ancient Roman empire grew to its greatest extent, religion in the provinces underwent change. In this article, the author argues that glocalization as an explicit modern conceptual framework has added value to the analysis of religious material culture. First, the glocalization model is discussed in the context of a wider debate on the biased concept of Romanization. Second, a rationale is presented for interpreting Roman religious change with a glocalization perspective. Third, two concrete bodies of archaeological source material are re-interpreted within the glocalization framework: first the little studied rural sanctuary of Dhronecken near ancient Trier and second a particular form of religious gifts that appeared on an empire-wide scale as a ritual with respect to the salus, the well-being of the emperor. Based on the application of the glocalization framework to these sources, the author concludes that religious material culture in these cases can be seen as a process in which new forms of religious communication were created out of an interrelated and ongoing process of local and global cultural expressions.