Introduction: African-American women living with HIV report substantial HIV-related stigma and depression. Resilience resources are strength-based resources that may moderate the effects of HIV-related stigma on poor psychosocial outcomes such as depression. Objective: To evaluate whether religiosity, social support and ethnic identity moderate the effects of HIV-related stigma on depression among African-American women living with HIV. Methods: We used baseline data (5/2013-10/2015) from a randomized controlled trial testing the efficacy of an HIV-related stigma reduction intervention among African-American women living with HIV in Chicago, IL and Birmingham, AL who were >18 years old and currently receiving HIV services. To assess whether religiosity (7-item Religious Beliefs and Behaviors survey, RBB), social support (select subscales from the Medical Outcomes Study Social Support Survey, MOS-SSS), and ethnic identity (Commitment subscale from the Multigroup Ethnic Identity Measure, MEIM-R) modified the relationship between HIV-related stigma (Stigma Scale for Chronic Illness, SSCI) and depression (8-item Patient Health Questionnaire, PHQ-8), we conducted three separate moderation analyses using linear regression with interactions between HIV-related stigma and each moderator of interest, adjusted for study site, age, time since diagnosis, and education. Results: Among 226 African-American women living with HIV, greater levels of HIV-related stigma were associated with greater depression in all three models (p < 0.05). Only religiosity modified this association (p = 0.04), with a weaker association among women reporting higher levels of religiosity. Conclusions: The protective effects of religiosity may be leveraged in interventions for African-American women living with HIV struggling with HIV-related stigma.