PurposeCardiovascular diseases (CVDs) are responsible for one-third of global deaths. Work stress is a major risk factor for CVDs in the workforce. Construction professionals endure excessive work stress, yet their vulnerability to CVDs remains underexplored. The study investigated the prevalence of CVDs among construction professionals and its relationships to job stressors, stress coping methods and socio-demographics.Design/methodology/approachAn online survey was conducted among construction professionals in Australia wherein data related to job stressor experiences, stress management methods adopted, and incidents of CVDs were collected. Structural path analysis was conducted to discover associations.FindingsJunior level professionals reported higher incidents of angina and heart muscle weakening than others. Statistically significant positive associations were discovered between the reported CVDs, and job stressors such as excessive workload, unpredictable work hours, lack of support, discrimination and work–life conflict and negative stress coping methods such as consuming alcohol and/or drugs, emotional eating and aggression. However, no evidence was found to support the claim that demographic factors such as age and gender were also risk factors for CVDs.Originality/valueThe workers' compensation system provides financial protection to injured employees. It extends similar protection for work-related illnesses; however, it is more difficult to prove work-related causes for illnesses. The study provides scientific evidence to support the recognition of CVDs among construction professionals as work-related diseases, mediated by work stress.