Reliving Traumatic Memory as Sensory and Motor Fragments: Examining the Default Mode and Sensorimotor Networks During Moral Injury Autobiographical Memory Retrieval in Ptsd

Kearney, Breanne E.; Terpou, Braeden A.; Densmore, Maria; Shaw, Saurabh Bhaskar; Théberge, Jean; McKinnon, Margaret C.; Lanius, Ruth A.

doi:10.2139/ssrn.4363667

Cited by 3 publications

(3 citation statements)

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“…Therefore, future studies examining these CAPs during either symptom provocation paradigms, prompted memory retrieval, or periodic probing for spontaneous memory emergence are warranted. Similarly, assessments of sensoryperceptual properties of TR-IMs beyond the visual system are needed, including somatosensory, auditory, and olfactory, as well as interoceptive sensations [16,97]. Additionally, our sample was predominantly female, precluding any investigations into sex differences despite known effects of sex on PTSD symptoms.…”

Section: Discussionmentioning

confidence: 99%

Spatiotemporal dynamics of hippocampal-cortical networks underlying the unique phenomenological properties of trauma-related intrusive memories

Clancy,

Devignes,

Ren

et al. 2024

Mol Psychiatry

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Trauma-related intrusive memories (TR-IMs) possess unique phenomenological properties that contribute to adverse post-traumatic outcomes, positioning them as critical intervention targets. However, transdiagnostic treatments for TR-IMs are scarce, as their underlying mechanisms have been investigated separate from their unique phenomenological properties. Extant models of more general episodic memory highlight dynamic hippocampal-cortical interactions that vary along the anterior-posterior axis of the hippocampus (HPC) to support different cognitive-affective and sensory-perceptual features of memory. Extending this work into the unique properties of TR-IMs, we conducted a study of eighty-four trauma-exposed adults who completed daily ecological momentary assessments of TR-IM properties followed by resting-state functional magnetic resonance imaging (rs-fMRI). Spatiotemporal dynamics of anterior and posterior hippocampal (a/pHPC)-cortical networks were assessed using co-activation pattern analysis to investigate their associations with different properties of TR-IMs. Emotional intensity of TR-IMs was inversely associated with the frequency and persistence of an aHPC-default mode network co-activation pattern. Conversely, sensory features of TR-IMs were associated with more frequent co-activation of the HPC with sensory cortices and the ventral attention network, and the reliving of TR-IMs in the “here-and-now” was associated with more persistent co-activation of the pHPC and the visual cortex. Notably, no associations were found between HPC-cortical network dynamics and conventional symptom measures, including TR-IM frequency or retrospective recall, underscoring the utility of ecological assessments of memory properties in identifying their neural substrates. These findings provide novel insights into the neural correlates of the unique features of TR-IMs that are critical for the development of individualized, transdiagnostic treatments for this pervasive, difficult-to-treat symptom.

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Section: Discussionmentioning

confidence: 99%

Spatiotemporal dynamics of hippocampal-cortical networks underlying the unique phenomenological properties of trauma-related intrusive memories

Clancy,

Devignes,

Ren

et al. 2024

Mol Psychiatry

View full text Add to dashboard Cite

show abstract

“…Therefore, future studies examining these CAPs during either symptom provocation paradigms, prompted memory retrieval, or periodic probing for spontaneous memory emergence are warranted. Similarly, assessments of sensory-perceptual properties of TR-IMs beyond the visual system are needed, including somatosensory, auditory, and olfactory, as well as interoceptive sensations [14,100,101]. Additionally, our sample was predominantly female, precluding any investigations into sex differences despite known effects of sex on PTSD symptoms, sensory processing, and cognition.…”

Section: Discussionmentioning

confidence: 99%

Spatiotemporal dynamics of hippocampal-cortical networks underlying the unique phenomenological properties of trauma-related intrusive memories

Clancy

Devignes

Ren

et al. 2023

Preprint

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Trauma-related intrusive memories (TR-IMs) possess unique phenomenological properties that contribute to adverse post-traumatic outcomes, positioning them as critical intervention targets. However, transdiagnostic treatments for TR-IMs are scarce, as their underlying mechanisms have been investigated separate from their unique phenomenological properties. Extant models of more general episodic memory highlight dynamic hippocampal-cortical interactions that vary along the anterior-posterior axis of the hippocampus (HPC) to support different cognitive-affective and sensory-perceptual features of memory. Extending this work into the unique properties of TR-IMs, we conducted a study of eighty-four trauma-exposed adults who completed daily ecological momentary assessments of TR-IM properties followed by resting-state functional magnetic resonance imaging (rs-fMRI). Spatiotemporal dynamics of anterior and posterior hippocampal (a/pHPC)-cortical networks were assessed using co-activation pattern analysis to investigate their associations with different properties of TR-IMs. Emotional intensity of TR-IMs was inversely associated with the frequency and persistence of an aHPC-default mode network co-activation pattern. Conversely, sensory features of TR-IMs were associated with more frequent co-activation of the HPC with sensory cortices and the ventral attention network, and the reliving of TR-IMs in the “here-and-now” was associated with more persistent co-activation of the pHPC and the visual cortex. Notably, no associations were found between HPC-cortical network dynamics and conventional symptom measures, including TR-IM frequency or retrospective recall, underscoring the utility of ecological assessments of memory properties in identifying the neural substrates of memory properties. These findings provide novel mechanistic insights into the unique features of TR-IMs that are critical for the development of individualized, transdiagnostic treatments for this pervasive, difficult-to-treat symptom.

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“…One study found that the somatosensory-motor network (SMN), comprised of the pre- and post-central gyri (primary motor cortex and somatosensory cortex, respectively), the primary sensory cortices, and the supplementary motor area (SMA), undergoes a within-network decrease in functional connectivity in those with PTSD, especially in the somatosensory cortex ( Shang et al, 2014 ), which is consistent with catastrophic, fearful orientation to somatic signals in PTSD ( Tsur et al, 2018 ). Conversely, hyperconnectivity between the posterior DMN and SMN in PTSD is consistent with symptoms such as involuntary re-experiencing of, vivid sensory-motor imprints of the original traumatic memory ( Kearney et al, 2023 ). Based on these findings, it is reasonable to hypothesize that PTSD may involve abnormal connectivity between the hippocampus and SMN.…”

Section: Introductionmentioning

confidence: 99%

Altered Resting-State functional connectivity in the anterior and posterior hippocampus in Post-traumatic stress disorder: The central role of the anterior hippocampus

Chaposhloo

Nicholson

Becker

et al. 2023

NeuroImage: Clinical

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Reliving Traumatic Memory as Sensory and Motor Fragments: Examining the Default Mode and Sensorimotor Networks During Moral Injury Autobiographical Memory Retrieval in Ptsd

Cited by 3 publications

References 0 publications

Spatiotemporal dynamics of hippocampal-cortical networks underlying the unique phenomenological properties of trauma-related intrusive memories

Spatiotemporal dynamics of hippocampal-cortical networks underlying the unique phenomenological properties of trauma-related intrusive memories

Spatiotemporal dynamics of hippocampal-cortical networks underlying the unique phenomenological properties of trauma-related intrusive memories

Altered Resting-State functional connectivity in the anterior and posterior hippocampus in Post-traumatic stress disorder: The central role of the anterior hippocampus

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