With the development of society, antibiotics have been widely used in human and animal bacterial infections [1]. Due to their limited biodegradability, they can be detected in soil, surface water, and surface sediments [2]. Oxytetracycline (OTC) is a tetracycline antibiotic with a broad range of action. Because of its inexpensive cost and therapeutic impact, OTC is commonly utilized in aquaculture and animal husbandry. Once OTC is extensively used and not properly treated, the residual OTC will harm the ecological environment [3]. The issues contain bacterial resistance and resistance genes. Therefore, the impact of antibiotic resistance on human health needs to be