REM-density has a dual indicator function in depression

Hemmeter, Ulrich; Hobi, V.; Gerhard, Urs; Seifritz, Erich; Hatzinger, Martin; Brüderlin, U.; Holsboer‐Trachsler, Edith

doi:10.1016/s0006-3223(97)87961-9

Cited by 2 publications

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“…Although this study revealed only subtle effects on memory and psychomotor performance by both active substances, the suppression of REM density, which reflects a rather sensitive parameter of cognitive and memory performance (Karni et al 1994;Smith et al 1996;Kavanau 1997;Hemmeter et al 1998) has highlighted the potential memory impairing properites of these compounds, which might exert its effects on cognition via the linkage of GABAergic and cholinergic neurotransmission. In this regard, the results on procedural memory, which is supposed to be specifically linked to REM sleep (Dotto 1996;Smith et al 1996) and which did not improve after treatment with both active substances especially in the first half of the night, but within the placebo condition, may reflect a particular consequence of the REM density suppression by both drugs.…”

Section: Discussionmentioning

confidence: 69%

Effect of zopiclone and temazepam on sleep EEG parameters, psychomotor and memory functions in healthy elderly volunteers

et al. 2000

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Zopiclone and temazepam can be considered as effective hypnotics in elderly subjects when administered in that dosage. The superiority of zopiclone on sleep architecture may be related to a more specific action of zopiclone at the GABA-A benzodiazepine receptor complex. The suppression of REM density by both compounds and their subtle effects on cognition may reflect a GABAergic mediated reduction of cholinergic neuro-transmission.

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Section: Discussionmentioning

confidence: 69%

Effect of zopiclone and temazepam on sleep EEG parameters, psychomotor and memory functions in healthy elderly volunteers

et al. 2000

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“…Trimipramine is one of the rare antidepressants which do not exert major effects on sleep architecture, particularly it does not suppress REM sleep. Thus, variation of sleep pattern due to further stimulations can be studied well under constant trimipramine medication [16,17,55,58,59].…”

Section: Medicationmentioning

confidence: 99%

Polysomnographic Effects of Adjuvant Ginkgo Biloba Therapy in Patients with Major Depression Medicated with Trimipramine1

Hemmeter¹,

Annen²,

Bischof³

et al. 2001

Pharmacopsychiatry

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Sleep disturbance and cognitive impairment are frequent complaints of depressed patients under standard antidepressant medication. Therefore, additional therapies are required which specifically focus on the improvement of these deficits without exerting major side effects. Ginkgo biloba extract (EGb) has been shown to improve cognitive abilities in elderly subjects and in patients with disorders of the dementia spectrum. Animal studies surmise that EGb may reduce CRH activity, which is substantially related to depressive mood and behavior, predominantly cognition and sleep. An open non-randomized pilot study has been conducted to investigate the effects of ginkgo biloba extract (EGb Li 1370) on cognitive performance and sleep regulation in depressed inpatients. 16 patients were treated with a trimipramine (T)-monotherapy (200 mg) for six weeks. In eight of the 16 patients, an adjunct EGb therapy (240 mg/d) was applied for four weeks after a baseline week, the other eight patients remained on trimipramine monotherapy (200 mg) during the entire study. Polysomnography, cognitive psychomotor performance and psychopathology were assessed at baseline, after short-term and long-term adjunct EGb treatment, and after one week of ginkgo discontinuation (at the respective evaluation times in the eight patients on T-monotherapy). This report focuses on the results of EGb on sleep EEG pattern. EGb significantly improved sleep pattern by an increase of sleep efficiency and a reduction of awakenings. In addition, sleep stage 1 and REM-density were reduced, while stage 2 was increased. Non-REM sleep, predominantly slow wave sleep in the first sleep cycle, was significantly enhanced compared to trimipramine monotherapy. Discontinuation of EGb reversed most of these effects. Based on the animal data, these results suggest that EGb may improve sleep continuity and enhance Non-REM sleep due to a weakening of tonic CRH-activity. The compensation of the deficient Non-REM component in depression by the EGb application may provide a new additional treatment strategy, especially in the treatment of the depressive syndrome with sleep disturbance.

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REM-density has a dual indicator function in depression

Cited by 2 publications

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Effect of zopiclone and temazepam on sleep EEG parameters, psychomotor and memory functions in healthy elderly volunteers

Effect of zopiclone and temazepam on sleep EEG parameters, psychomotor and memory functions in healthy elderly volunteers

Polysomnographic Effects of Adjuvant Ginkgo Biloba Therapy in Patients with Major Depression Medicated with Trimipramine1

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