1969
DOI: 10.1016/0013-4694(69)90208-9
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REM sleep and NREM sleep in narcolepsy and hypersomnia

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Cited by 45 publications
(8 citation statements)
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“…We further identified several catecholaminergic receptor subtypes specifically involved in the regulation of cataplexy, namely adrenergic postsynaptic ␣ -1b, presynaptic ␣ -2 and dopaminergic D2-type receptors (Mignot et al 1989;Nishino et al 1991Nishino et al , 1993bNishino et al , 1995. These results are also compatible with the recent discoveries of a deficit in hypocretin neurotransmission in narcolepsy (Chemelli et al 1999;Lin et al 1999;Nishino et al 2000b) since hypocretin neurons project intensively to monoaminergic cell groups and are excitatory in nature Hagan et al 1999;Peyron et al 1998).Because narcoleptic patients often exhibit sleep onset REM periods (SOREMPs), it is believed that REM sleep can intrude in active wake or sleep onset, resulting in cataplexy, sleep paralysis and hypnagogic hallucinations (Roth et al 1969;Takahashi 1971). Thus, abnormal generation of REM sleep might be central to narcolepsy.…”
supporting
confidence: 70%
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“…We further identified several catecholaminergic receptor subtypes specifically involved in the regulation of cataplexy, namely adrenergic postsynaptic ␣ -1b, presynaptic ␣ -2 and dopaminergic D2-type receptors (Mignot et al 1989;Nishino et al 1991Nishino et al , 1993bNishino et al , 1995. These results are also compatible with the recent discoveries of a deficit in hypocretin neurotransmission in narcolepsy (Chemelli et al 1999;Lin et al 1999;Nishino et al 2000b) since hypocretin neurons project intensively to monoaminergic cell groups and are excitatory in nature Hagan et al 1999;Peyron et al 1998).Because narcoleptic patients often exhibit sleep onset REM periods (SOREMPs), it is believed that REM sleep can intrude in active wake or sleep onset, resulting in cataplexy, sleep paralysis and hypnagogic hallucinations (Roth et al 1969;Takahashi 1971). Thus, abnormal generation of REM sleep might be central to narcolepsy.…”
supporting
confidence: 70%
“…Because narcoleptic patients often exhibit sleep onset REM periods (SOREMPs), it is believed that REM sleep can intrude in active wake or sleep onset, resulting in cataplexy, sleep paralysis and hypnagogic hallucinations (Roth et al 1969;Takahashi 1971). Thus, abnormal generation of REM sleep might be central to narcolepsy.…”
mentioning
confidence: 99%
“…Some authors (Dement et al, 1966;Suzuki, 1966) postulate that narcolepsy without accessory symptoms is due to a disturbance of NREM sleep mechanisms, while narcolepsy with accessory symptoms of cataplexy and sleep paralysis results from upset of REM sleep mechanisms. Roth et al (1969) found that narcolepsy on its own may result from disturbance of either REM or NREM sleep, but agreed that cataplexy and sleep paralysis are manifestations of REM sleep abnormality, and that REM sleep is regulated by the pontine reticular formation.…”
Section: Discussionmentioning
confidence: 99%
“…Motor and other behaviors identified in patients with narcolepsy include, in addition to PLMs and RBD, automatic behavior, 32 binge eating/eating disorders, 33 and other compulsive disorders 34 . Patients with narcolepsy not only present daytime somnolence with sleep episodes, but also their sleep is disrupted by nocturnal awakenings, disruption of the NREM/REM cycle, the latter being most pronounced in NC patients 1,35–38 . This dysregulation of the sleep–wake cycle and REM/NREM stability may be attributed in part to hypocretin deficit 39 .…”
Section: Motor and Behavioral Abnormalities Identified In Patients Wimentioning
confidence: 99%