REM sleep deprivation induces changes of Down Regulatory Antagonist Modulator (DREAM) expression in the ventrobasal thalamic nuclei of Sprague–Dawley rats

Siran, Rosfaiizah; Ahmad, Asma Hayati; Aziz, Che Badariah Abdul; Ismail, Zawawi Bin

doi:10.1007/s13105-014-0356-x

Cited by 9 publications

(23 citation statements)

References 54 publications

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“…Previous studies have used a variety of techniques, including single platform (Gulyani, Majumdar, & Mallick, 2000), disc-over-water (Gulyani et al, 2000;Jiang et al, 2017;Ramanathan et al, 2002) and multiple platforms (Lima, de Bruin, Rios, & de Bruin, 2014). These different techniques have produced a similar feature, consisting of an increase in food consumption but a decrease in bodyweight gain (Hipolide et al, 2006;Koban & Stewart, 2006;Siran et al, 2014), similar to our findings. As a result, our results have confirmed the occurrence of REM sleep deprivation using the selected protocol.…”

Section: Deprivation Of Rem Sleep Is Associated With Decreased Body Wsupporting

confidence: 89%

Lipid peroxidation in the descending thoracic aorta of rats deprived of REM sleep using the inverted flowerpot technique

Nawi

Faris

et al. 2020

Experimental Physiology

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Oxidative stress-mediated lipid peroxidation is a known cause of endothelial injury or dysfunction. Deprivation of rapid eye movement (REM) sleep is associated with oxidative stress. To date, the pathogenesis of increased blood pressure after sleep deprivation remains poorly understood, particularly in the REM sleep phase. Our aim was to investigate the effects of REM sleep deprivation on blood vessels in the REM sleep-deprived rat model. Twenty-eight male Sprague-Dawley rats were divided into four equal groups: free-moving control rats, rats deprived of REM sleep for 72 h (REMsd), tank control rats and 72 h sleep-recovered rats after 72 h of REM sleep deprivation. The rats were deprived of REM sleep using the inverted flowerpot technique. Food consumption, body weight gain and systolic blood pressure were monitored. At the end of the experiment, the descending thoracic aorta was isolated for the measurement of oxidative stress markers. Despite a significant increase in food consumption in the REMsd group compared with the other groups, there was a significant reduction in body weight gain. Systolic blood pressure also showed a significant increase in the REMsd group compared with the other groups. Superoxide dismutase activity was significantly lower and malondialdehyde concentrations significantly higher in the REMsd group compared with the other groups. Increased levels of malondialdehyde are suggestive of lipid peroxidation in the blood vessels, and oxidative stress may be attributed to the initiation of the process. The changes after REM sleep deprivation revert during sleep recovery. In conclusion, the findings of the present study provide convincing evidence that REM sleep deprivation induced lipid peroxidation, leading to endothelial damage.

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Section: Deprivation Of Rem Sleep Is Associated With Decreased Body Wsupporting

confidence: 89%

Lipid peroxidation in the descending thoracic aorta of rats deprived of REM sleep using the inverted flowerpot technique

Nawi

Faris

et al. 2020

Experimental Physiology

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“…The inverted flowerpot method was modified based on our previously study (Siran, Ahmad, Abdul Aziz, & Ismail, ) and used to selectively induce REM sleep deprivation for 72 hr. Before the start of the experiment, all rats except from control group were isolated and adapted individually in a dry tank model for 72 hr before being exposed to the REM sleep deprivation model.…”

Section: Methodsmentioning

confidence: 99%

Nicotine‐prevented learning and memory impairment in REM sleep‐deprived rat is modulated by DREAM protein in the hippocampus

Rashid

Hapidin²,

Abdullah³

et al. 2017

Brain and Behavior

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Introduction REM sleep deprivation is associated with impairment in learning and memory, and nicotine treatment has been shown to attenuate this effect. Recent studies have demonstrated the importance of DREAM protein in learning and memory processes. This study investigates the association of DREAM protein in REM sleep‐deprived rats hippocampus upon nicotine treatment.MethodsMale Sprague Dawley rats were subjected to normal condition, REM sleep deprivation and control wide platform condition for 72 hr. During this procedure, saline or nicotine (1 mg/kg) was given subcutaneously twice a day. Then, Morris water maze (MWM) test was used to assess learning and memory performance of the rats. The rats were sacrificed and the brain was harvested for immunohistochemistry and Western blot analysis.Results MWM test found that REM sleep deprivation significantly impaired learning and memory performance without defect in locomotor function associated with a significant increase in hippocampus DREAM protein expression in CA1, CA2, CA3, and DG regions and the mean relative level of DREAM protein compared to other experimental groups. Treatment with acute nicotine significantly prevented these effects and decreased expression of DREAM protein in all the hippocampus regions but only slightly reduce the mean relative level of DREAM protein.ConclusionThis study suggests that changes in DREAM protein expression in CA1, CA2, CA3, and DG regions of rat's hippocampus and mean relative level of DREAM protein may involve in the mechanism of nicotine treatment‐prevented REM sleep deprivation‐induced learning and memory impairment in rats.

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“…The REM sleep deprivation model was carried out by modification of the inverted flowerpot technique (Siran et al, 2014). Two small platforms, of 6.5 cm in diameter each, were placed in the middle of a glass tank immersed in water.…”

Section: Rem Sleep Deprivation Modelmentioning

confidence: 99%

“…Good quality of sleep is crucial for human health and well-being, regardless of age and gender. Sleep is vital for conserving energy, cell functioning and increasing brain protein synthesis (Siran et al, 2014). Sleep deprivation has become an emerging public health issue globally (Chattu et al, 2019), thus sleep deprivation has attracted the interest of many researchers for many years.…”

Section: Introductionmentioning

confidence: 99%

“…The characteristics of REM sleep include vivid dreams, loss of muscle tone, increased brain metabolism and memory consolidation (Wiesner et al, 2015). Effects of REM sleep deprivation on memory (Wiesner et al, 2015), pain-related gene expression (Siran et al, 2014), behaviour (Hanlon et al, 2005) and Abstract: Sleep deprivation increased risk for cardiovascular disease. This study aims to evaluate the effect of rapid eye movement (REM) sleep deprivation on the endothelium.…”

Section: Introductionmentioning

confidence: 99%

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Volume 15 Number 8, December 2020: 22-33 IMPACT OF REM SLEEP DEPRIVATION ON ENDOTHELIAL FUNCTION IN RAT MODEL: ROLE OF VITAMIN C SUPPLEMENTATION

NAWI¹,

ADNAN²,

Ahmad³

et al. 2020

J. Sustain. Sci. Manage.

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REM sleep deprivation induces changes of Down Regulatory Antagonist Modulator (DREAM) expression in the ventrobasal thalamic nuclei of Sprague–Dawley rats

Cited by 9 publications

References 54 publications

Lipid peroxidation in the descending thoracic aorta of rats deprived of REM sleep using the inverted flowerpot technique

Lipid peroxidation in the descending thoracic aorta of rats deprived of REM sleep using the inverted flowerpot technique

Nicotine‐prevented learning and memory impairment in REM sleep‐deprived rat is modulated by DREAM protein in the hippocampus

Volume 15 Number 8, December 2020: 22-33 IMPACT OF REM SLEEP DEPRIVATION ON ENDOTHELIAL FUNCTION IN RAT MODEL: ROLE OF VITAMIN C SUPPLEMENTATION

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