Remarkable deprotection of THP and THF ethers catalysed by cerium ammonium nitrate (CAN) under neutral conditions

Hydrated ferric perchlorate, Fe(ClO4)3.XH2O in organic synthesis. A short review

“…Although there are several methods for deprotection of THP ethers [59][60][61][62] and conversion of alcohols into acetates, methods for direct conversion of THP ethers to acetate are limited and even those suffer from serious drawbacks. The method available for the direct conversion of THP ethers to the corresponding acetates include FeCl 3 /Ac 2 O, AcOH/AcCl, Ti/Ac 2 O, bismuth salts, Cu(OTf) 2 /Ac 2 O and ZrCl 4 [63][64][65][66][67][68].…”

Recent advances in CAN mediated reactions in organic synthesis

“…Good selectivity was observed in the presence of other protecting groups, which allowed the selective deprotection of a THP group in the presence of a trityloxy substituent (Scheme 27). 149 The ability of CAN to cleave the C-Si bond was utilized for the removal of the N-[bis(trimethylsilyl)methyl] moiety from the b-lactam 155. 150 Removal of t-Boc group from organic compounds under neutral conditions was effected using catalytic amounts of CAN in acetonitrile.…”

Ferric perchlorate: A novel and highly efficient catalyst for direct acetylation of THP ethers with acetic acid

“…Although there are several method for deprotection of THP ethers [5][6][7][8] and conversion of alcohols into acetates, methods for direct conversion of THP ethers to acetate are limited and even those suffer from serious drawbacks. The method available for the direct conversion of THP ethers to the corresponding * Corresponding author.…”