Remarkably flexible 2,2′:6′,2″-terpyridines and their group 8–10 transition metal complexes – Chemistry and applications

Panicker, Rakesh R.; Sivaramakrishna, Akella

doi:10.1016/j.ccr.2022.214426

Cited by 46 publications

(30 citation statements)

References 395 publications

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“…S54†). 11,13 In contrast, the complexes L2 2 -M displayed a new and red-shifted absorption at about 370 nm (Fig. 7A and Fig.…”

Section: Resultsmentioning

confidence: 94%

“…1) is a tridentate ligand and is able to coordinate with most transition metal ions to generate an octahedral geometry. 11–13 As observed from the structure of Tpy compounds, there are many modifiable sites. Among these, 4′-substituted terpyridine complexes have attracted the most attention of researchers due to their facile synthesis and interesting photophysical and chemical properties.…”

Section: Introductionmentioning

confidence: 99%

“…1) is a tridentate ligand and is able to coordinate with most transition metal ions to generate an octahedral geometry. [11][12][13] As observed from the structure of Tpy compounds, there are many modifiable sites. Among these, 4′-substituted terpyridine complexes have Fig.…”

Section: Introductionmentioning

confidence: 99%

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Substituents make a difference: 6,6″-modified terpyridine complexes with helix configuration and enhanced emission

Liu

Zhao

et al. 2023

Dalton Trans.

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“…S54†). 11,13 In contrast, the complexes L2 2 -M displayed a new and red-shifted absorption at about 370 nm (Fig. 7A and Fig.…”

Section: Resultsmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

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Substituents make a difference: 6,6″-modified terpyridine complexes with helix configuration and enhanced emission

Liu

Zhao

et al. 2023

Dalton Trans.

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“…Ruthenium(II) polypyridine complexes have long been the interest of researchers owing to their abundant properties related to optical physics, chemistry, and electrochemistry, which enable them to function well in fields of (i) energy conversion including dye-sensitized solar cells , and dye-sensitized photoelectrochemical cells (DS-PECs); (ii) luminescence including organic light-emitting diodes (OLEDs) , and light-emitting electrochemical cells; (iii) biomedical researches like detection, bioimaging, and anticancer; − (iv) catalyst for chemical reactions. − Bearing a strong chelating effect, ruthenium(II) terpyridine complexes exhibit fine photostability and achiral configurations, which are suitable for constructing ordered multinuclear assembly architectures based on the specific design. Nevertheless, ruthenium(II) terpyridine complexes have been suffering from low intrinsic quantum yields and short lifetime of excited states, caused by fast energy transfer from the emissive 3 MLCT state to the nonemissive triplet metal-centered 3 MC state, which arises from their distorted octahedral geometries due to the terpyridine related N–Ru–N trans angle of ca.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Theoretical and Photophysical Study on a Series of Neutral Ruthenium(II) Complexes with Donor–Metal–Accepter Configuration

2023

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In order to construct a new type of ruthenium(II) terpyridine complexes with activated triplet metal-centered (3MC) states, as well as stabilized triplet metal-to-ligand charge transfer (3MLCT) states, conducive to fine emissive performances, Ru-1, Ru-2, Ru-3, and Ru-4 were synthesized. Compared with the [Ru(terpyridine)2]2+ prototype (0.25 ns), this series of ruthenium(II) terpyridine complexes exhibit lengthened excited state lifetime (43.3 ns for Ru-1, 52.7 ns for Ru-2, 43.6 ns for Ru-3, and 53.4 ns for Ru-4). Interfragment charge transfer analysis illustrates the electron transfer direction of the four complexes, manifesting their intramolecular charge transfer characteristic. When excited, their lowest-lying triplet states are assigned as 3MLCT based on spin-density surface distribution. The singlet excited states and 3MLCT states were thoroughly studied by UV–visual absorption and nanosecond time-resolved transient absorption spectra, respectively. Photoluminescence spectra revealed their weak broadband near-infrared emission at room temperature and red phosphorescence at 77 K. The low molecular weight and the good thermal stability make Ru-1 and Ru-2 suitable for vaporization coating, while the fine solubility in common organic solvents makes Ru-3 and Ru-4 suitable for solution processing. Furthermore, the intrinsic electroneutrality and favorable energy levels endow them with new potential to be applied in the optoelectronic field.

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“…The inability of chemotherapy in distinguishing the cancer cells and normal cells leads to significant side effects and acute toxicity [1–6] . In this regard, numerous N‐heterocyclic molecules have been designed and investigated to check their ability as targeted anti‐cancer drug candidates [7–14] . According to the World Cancer Report, breast cancer is the leading cause of mortality for women around the globe [15] .…”

Section: Introductionmentioning

confidence: 99%

Designing, Synthesis, and Anti‐Breast Cancer Activity of a Series of New Quinazolin‐4(1H)‐one Derivatives

Reddy

Rajagopal

Naik

et al. 2022

Chemistry & Biodiversity

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The inhibition of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) protein could be a promising treatment for breast cancer. In this regard, docking studies were accomplished on various functionalized organic molecules. Among them, several derivatives of quinazolin-4(1H)-one exhibited anti-breast cancer activity and satisfied the drug likeliness properties. Further, the in vitro inhibitory studies by a series of 2-(2-phenoxyquinolin-3-yl)-2,3-dihydroquinazolin-4(1H)-one molecules showed strong anti-cancer activity than the currently available drug, wortmannin. The MTT cytotoxicity assay was used to predict the anti-proliferative activity of these drugs against MCF-7 cancer cells by inhibiting the PIK3CA protein. The dose-dependent analysis showed a striking decrease in cancer cell viability at 24 h with inhibitory concentrations (IC 50 ) of 3b, 3c, 3d, 3f and 3m are 15 � 1, 17 � 1, 8 � 1, 10 � 1 and 60 � 1 (nanomoles), respectively. This is the first report in the literature on the inhibition of PIK3CA protein by quinazolinone derivatives that can be used in the treatment of cancer. Quinazolinone analogs have the potential to be safe and economically feasible scaffolds if they are produced using a chemical technique that is both straightforward and amenable to modification. From the cancer research perspective, this study can eventually offer better care for cancer patients.

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Remarkably flexible 2,2′:6′,2″-terpyridines and their group 8–10 transition metal complexes – Chemistry and applications

Cited by 46 publications

References 395 publications

Substituents make a difference: 6,6″-modified terpyridine complexes with helix configuration and enhanced emission

Substituents make a difference: 6,6″-modified terpyridine complexes with helix configuration and enhanced emission

Synthesis and Theoretical and Photophysical Study on a Series of Neutral Ruthenium(II) Complexes with Donor–Metal–Accepter Configuration

Designing, Synthesis, and Anti‐Breast Cancer Activity of a Series of New Quinazolin‐4(1H)‐one Derivatives

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