Remarks About Retrospective Analysis of Ivermectin Effectiveness on Coronavirus Disease 2019 (ICON Study)

Ortega-Guillén, Eduardo; Meneses, Giovanni; Coila, Edgar

doi:10.1016/j.chest.2020.10.088

Cited by 2 publications

(1 citation statement)

References 5 publications

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“…In the shortage of truly effective agents against the SARS-CoV-2 virus, repurposing/trials of existing drugs are taking place in many parts of the world. These included the controversial animal antiparasite drug ivermectin (Ortega-Guillén et al, 2021;Rajter et al, 2021), the commonly used antimalarials chloroquine (CQ) and hydroxychloroquine (HCQ) (Abena et al, 2020) and psychotropics described above. These two areas are important for future research in the fight against COVID-19.…”

Section: Areas Of Further Research In Long Covidmentioning

confidence: 99%

Long COVID, neuropsychiatric disorders, psychotropics, present and future

Tang

Leonard

Helmeste

2022

Acta Neuropsychiatr.

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Long-COVID refers to the lingering or protracted illness long after the acute illness. Depression, anxiety, fatigue, concentration and cognitive impairment appeared to be reported often in long COVID, psychosis seemed uncommon. Neuropsychiatric disorders in long COVID could be a consequence of direct viral insult on the central nervous system (CNS), continuous neuroinflammation, or neurodegeneration and metabolic impairment following the cerebral vascular accidents, or hypoxia from pulmonary damages and fibrotic changes. It is important to know how patients with various disorders, not only neuropsychiatric disorders, thrive under long COVID. How much the neuropsychiatric disorders reported in long COVID are stress related in nature, due to prolonged quarantine and social isolation, would also be important to study. Patients with diabetes are already known to have a higher risk of mortality and morbidity in COVID-19. How brain glucose metabolism may contribute to the neuropsychiatric symptoms in long COVID is an important area for COVID-19 research. Patients on psychotropics often asked their clinicians about potential conflicts of their medications with anti-COVID 19 vaccinations, or whether it would increase their vulnerability to COVID-19 viral infection. Thus, early reports of protective effects of psychotropics against COVID-19 need to be validated. Some antidepressant and antipsychotic agents indeed possess significant affinities for the sigma-1 and histamine receptors. This, with the earlier reports of reduced number of sigma-1 receptors in post- mortem schizophrenic brains and the reported roles of sigma and histamine receptors in neuroinflammation and viral infections, may point to an important and novel direction for drug discovery against COVID-19. Literature and data in all these areas are accumulating at a fast rate. We reviewed and discussed the relevant and important literature.

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Section: Areas Of Further Research In Long Covidmentioning

confidence: 99%

Long COVID, neuropsychiatric disorders, psychotropics, present and future

Tang

Leonard

Helmeste

2022

Acta Neuropsychiatr.

View full text Add to dashboard Cite

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Ivermectina un medicamento de uso indiscriminado en el manejo del Covid-19

Amaya-Aponte

2021

MedUNAB

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Los Coronaviridae son una familia de virus ARN que han afectado, a lo largo de la historia, a mamíferos y aves. Estos patógenos, conocidos y estudiados por varias décadas, también han sido los responsables de infecciones que usualmente se presentan en el tracto respiratorio en humanos. Su más reciente variante SARS-CoV-2, fue identificada a finales del año 2019 en la ciudad china de Wuhan donde el virus fue identificado como el causante de múltiples neumonías severas en la población (1). Dicho brote tuvo una extensión que superó las expectativas, creando el hito más grande del siglo XXI. El 11 de marzo de 2020 el virus fue declarado pandemia, su transmisión de forma directa de persona a persona jugó un papel muy importante en el rápido esparcimiento de este nuevo coronavirus. Su gran abanico de presentación clínica, que parte desde formas completamente asintomáticas hasta llegar a infecciones de tracto respiratorio más graves e incluso mortales, jamás antes vistas (2), se convirtió en un reto social, político y médico.

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Remarks About Retrospective Analysis of Ivermectin Effectiveness on Coronavirus Disease 2019 (ICON Study)

Cited by 2 publications

References 5 publications

Long COVID, neuropsychiatric disorders, psychotropics, present and future

Long COVID, neuropsychiatric disorders, psychotropics, present and future

Ivermectina un medicamento de uso indiscriminado en el manejo del Covid-19

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