In this paper we consider Monge-Ampère equations on compact Hessian manifolds, or equivalently Monge-Ampère equations on certain unbounded convex domains Ω ⊆ R n , with a periodicity constraint given by the action of an affine group. In the case where the affine group action is volume-preserving, i.e., when the manifold is special, the solvability of the corresponding Monge-Ampère equation was established using the continuity method in [6]. In the general case we set up a variational framework involving certain dual manifolds and a generalization of the classical Legendre transform. We give existence and uniqueness results, elaborate on connections to optimal transport and quasi-periodic tilings of convex domains.