Remdesivir treatment and transient bradycardia in patients with coronavirus diseases 2019 (COVID-19)

Abstract

Are antigenic tests useful for detecting SARS-CoV-2 infections in patients accessing to emergency departments? Results from a North-West Italy hospital Dear Editor, In the article "Clinical application of a rapid antigen test for the detection of SARS-CoV-2 infection in symptomatic and asymptomatic patients evaluated in the emergency department: A preliminary report.", 1 Turcato et al. presented a study on the use of rapid antigenic tests (Ag-RDTs) instead of the usual real time reverse transcription polymerase chain reaction (RT-PCR) assay to de-

Bradycardia during remdesivir treatment might be associated with improved survival in patients with COVID-19: a retrospective cohort study on 473 patients from a tertiary centre

“…Our results demonstrate that bradycardia occurring during remdesivir use might reflect more favourable disease course and has a substantial potential for improving prognostication of patients with COVID-19. Frequency of bradycardia in our cohort (16.8%) was lower than previously reported in smaller patient cohorts (19%-47%) [2][3][4] which could be attributed to differences in baseline age, sex and comorbidity profile of patients. Underlying mechanisms behind bradycardia temporally associated with the administration of remdesivir remain elusive at the moment.…”

“…Remdesivir is the only antiviral drug currently approved for the treatment of severe COVID-19. It was recently observed that use of remdesivir might be associated with higher frequency of transitory bradycardia, [1][2][3][4] a phenomenon that was reported in 19%-47% of remdesivir-treated patients without clear clinical significance. Since a number of other potentially detrimental cardiovascular adverse events were reported with remdesivir use, 5 understanding clinical consequences of these phenomena is of outmost importance in everyday clinical practice.…”

“…Median Charlson Comorbidity Index (CCI) was 3 IQR. [2][3][4] At the time of hospital admission, a total of 382 (80.8%) patients presented with severe and 83 (17.5%) with critical COVID-19 symptoms. Median C reactive protein and interleukin-6 levels on admission were 110.7 mg/L and 44.2 pg/mL, respectively.…”

Post‐COVID‐19 maxillary osteonecrosis and floating maxillary teeth due to mucormycosis in two uncontrolled diabetic patients

“…Recently, the Indian Council of Medical Research (ICMR) suggested that clinicians and medical centers should consider clinical manifestations of mucormycosis such as sinus pain, nasal congestion on one side of the face, unilateral headache, swelling or numbness of the face, toothache, and floating of the teeth. 9 …”

“…Though the incidence of mucormycosis secondary to tooth extraction and floating is extremely low, when it occurs, it may cause significant morbidity and mortality. Recently, the Indian Council of Medical Research (ICMR) suggested that clinicians and medical centers should consider clinical manifestations of mucormycosis such as sinus pain, nasal congestion on one side of the face, unilateral headache, swelling or numbness of the face, toothache, and floating of the teeth 9 …”