Remedial Hypoglycemic Activity of n-Hexane Fraction of Hydro-Methanol Extract of Seed of<i>Swietenia mahagoni</i>(L.) jacq. in Streptozotocin-Induced Diabetic Rat: A Comparative Evaluation

Bera, Tushar Kanti; Chatterjee, Kanu; Ghosh, Debidas

doi:10.1080/10496475.2014.895920

Cited by 3 publications

(3 citation statements)

References 22 publications

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“…ese include anti-inflammatory, antioxidant, antibacterial, and antidiabetic activities [22][23][24][25]. erefore, the presence of these phytochemicals was the importance of the study and suggestive of their application in in vivo studies [16,26].…”

Section: Discussionmentioning

confidence: 99%

Histopathological Profiles of Rats (Rattus norvegicus) Induced with Streptozotocin and Treated with Aqueous Root Extracts of Ruellia tuberosa L.

Safitri

Sari

Refsilangi

et al. 2021

Veterinary Medicine International

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Diabetes mellitus (DM) is a serious worldwide health threat since the number of people with DM is forecasted to grow annually. Thus, effective and affordable treatment is urgently needed. Our previous studies used n-hexane and hydroethanolic root extracts of Ruellia tuberosa L. which significantly affected diabetic rats. In this study, aqueous R. tuberosa L. root extracts were used as treatments for the diabetic rat model and their effects were evaluated. Diabetes was generated by the administration of streptozotocin (STZ) at 20 mg/kg within 5 sequential days. Male Wistar rats were orally treated with the extracts and standard drug (metformin 200 mg/kg) and vehicle every day for 4 weeks. Hypoglycemic effects were assessed for normal, diabetic control, standard, and extract-treated groups. Histopathology was also carried out for the pancreatic, hepatic, and kidney tissues. The progression of diabetes was considerably diminished after extract treatment. In treated rats, the highest dose of extract induced a decline in blood glucose and serum malondialdehyde (MDA) levels at 25% and 35%, respectively. Furthermore, aqueous extract of R. tuberosa L. treatment decreased MDA levels in the pancreas by 12%. Histologic examination of the organ tissues of diabetic rats showed deteriorating alterations. After treatment, histopathological damages to the tissues and cells were reversed. The results of the experiments recommend that aqueous extract of R. tuberosa L. has antidiabetic effects on STZ-induced diabetic rats; nevertheless, a higher dose of the aqueous extracts is needed to achieve more significant results.

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Section: Discussionmentioning

confidence: 99%

Histopathological Profiles of Rats (Rattus norvegicus) Induced with Streptozotocin and Treated with Aqueous Root Extracts of Ruellia tuberosa L.

Safitri

Sari

Refsilangi

et al. 2021

Veterinary Medicine International

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Section: Introductionmentioning

confidence: 98%

“…Administration of different extract fractions of the hydro-methanolic extract of Swietenia mahagoni seed to streptozotocin-induced diabetic male albino rats reduced the FBGL at different day’s intervals after the application. Among all the extract fractions, the n-hexane fraction of hydro-methanolic extract of Swietenia mahagoni showed effectiveness (Bera et al , 2015). The alkaloids like palmatine, jatrorrhizine, and magnoflorine isolated from Tinospora cordifolia, showed a significant reduction in hepatic gluconeogenesis (Patel and Mishra, 2011).…”

Section: Introductionmentioning

confidence: 99%

Leaf Aqueous Extract ofManilkara hexandrainfluenced Glucose Metabolism in fish: An observation withLabeo rohitaFingerlings as model organism

Dutta

Chowdhury

Das

et al. 2021

Preprint

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Manilkara hexandra (Roxb.) Dubard (common name Khirni, family: Sapotaceae) is an evergreen traditionally used medicinal plant. The present study aimed to see the effects of leaf aqueous extract of M. hexandra (LAEMH) on digestive and glucose metabolic enzyme action and serum glucose level in rohu, Labeo rohita, fingerlings. Experimental fish were fed a basal diet (Group I), and diets supplemented with LAEMH at 300 mg (Group II) and 600 mg (Group III) kg−1 body weight. A significant reduction in serum glucose was noticed in the treated groups when compared with the control group. The reduced amylase activity was noticed in the treated fingerlings in a dose-dependent manner. However, lipase and protease activities didn’t differ significantly among the experimental groups. Reduced serum glucose level might be correlated with the decline in the activity of digestive amylase in fish. Group II (3.35±0.19U) and Group III (3.49±0.13 U) were recorded with reduced glucose-6-phosphatase activities than the control group (4.4±0.39 U). Moreover, the study revealed a decline in fructose-1,6-phosphatase activities in the treated groups in comparison to the control group. The decline in the activities of the metabolic enzymes might be associated with the non-availability of glucose owing to reduced activity of the digestive amylase in the treated groups. In conclusion, the present study established the hypoglycaemic effect of the leaf aqueous extract of M. hexandra in a fish model.

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2016

Plants With Anti-Diabetes Mellitus Properties

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Remedial Hypoglycemic Activity of n-Hexane Fraction of Hydro-Methanol Extract of Seed ofSwietenia mahagoni(L.) jacq. in Streptozotocin-Induced Diabetic Rat: A Comparative Evaluation

Cited by 3 publications

References 22 publications

Histopathological Profiles of Rats (Rattus norvegicus) Induced with Streptozotocin and Treated with Aqueous Root Extracts of Ruellia tuberosa L.

Histopathological Profiles of Rats (Rattus norvegicus) Induced with Streptozotocin and Treated with Aqueous Root Extracts of Ruellia tuberosa L.

Leaf Aqueous Extract ofManilkara hexandrainfluenced Glucose Metabolism in fish: An observation withLabeo rohitaFingerlings as model organism

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