Remedial Prospective of Hippophae rhamnoides Linn. (Sea Buckthorn)

Abstract

Sea buckthorn (Hippophae rhamnoides L.) constitutes thorny nitrogen fixing deciduous shrub. Sea buckthorn(SBT) is primarily valued for its very rich vitamins A, B1, B12, C, E, K, and P; flavonoids, lycopene, carotenoids, and phytosterols. and therapeutically important since it is rich with potent antioxidants. Scientifically evaluated pharmacological actions of SBT are like inflammation inhibited by reduced permeability, loss of follicular aggregation of lymphocytes from the inflamed synovium and suppress lymphocyte proliferation. SBT-reduced recurrence of angina, ischemic electrocardiogram which might be due to decreased myocardial oxygen consumption and inhibition of platelet aggregation induced by collagen. SBT can kill both cancer cells of S180, P388, SGC7901 and lymphatic leukemia (L1200). The antiulcer activity may be related to reduce gastric empty time, inhibiting proteolytic activity and promoting wound reparation processes of mucosa. SBT exerts antihypertensive effect in part by blocking angiotensin-2 receptor on cell surface. SBT decreased the level of stress hormones and enhanced hypoxic tolerance in animals indicating its anti-stress, adaptogenic activity. A lot of research work is still needed to find cellular and molecular mechanisms of these activities and also yet to be explored for its activity in osteoporosis, hemorrhage, cataract, urinary stone, acne, psoriasis, polyneuritis, cheilosis, glossities, baldness, anti-obesity, gout, and chronic prostitis.

Sea buckthorn (Hippophae rhamnoides L.) as a potential source of nutraceutics and its therapeutic possibilities - a review

“…One of the main components contributing to this effect is quercetin that induces apoptosis in cancer cells. The best effect has been reported in relation to the treatment of patients with colon cancer, leukaemia, and prostatic carcinoma (Patel et al 2012). Other studies suggest that sea buckthorn oil alleviates haematological damage caused by chemotherapy, such as part of treatment of leukaemia .…”

“…Their main function is suppression of platelet aggregation induced by collagen, probably by inhibition of the thyrosine kinase activity (Patel et al 2012). Another substance significantly contributing to platelet aggregation is sitosterol (Johansson et al 2000).…”

Antioxidant potential and total phenolic contents of seabuckthorn (Hippophae rhamnoides) pomace

“…A recent study by Kruczek et al [36] has showed the antioxidant capacity of crude extracts containing carotenoids from the berries of various cultivars of Seabuckthorn (Hippophae rhamnoides L.). Strong correlation was also observed between DPPH scavenging activity and total phenolic content from all Vinay Kant, et al: Antioxidant potential of seabuckthorn pomace the extracts of two species of sea-buckthorn; namely, Hippophae salicifolia D. Don and Hippophae rhamnoides L. [37] In review of Patel et al, [38] it has been described that seabuckthorn reduced recurrence of angina, ischemic electrocardiogram which might be due to decreased myocardial oxygen consumption and inhibition of platelet aggregation induced by collagen. So, in addition of the antioxidant properties of these extract, they can be validated for the prevention of these complications.…”

Botanical Antioxidants for Skin Health in the World of Cosmeceuticals

“…SBT is thorny nitrogen fixing deciduous shrub native to Europe and Asia, which is used as a medicinal plant in Tibetan and Mongolian traditional medicines (Lu, 1992;Patel et al, 2012;Rousi et al, 1971). Since the 1950's, many curative preparations of SBT have been clinically used to treat radiation damage, burns, oral inflammation and gastric ulcers in China and the former Soviet Republics (Fu et al, 1993;Geetha et al, 2002;Isoherranen et al, 1999;Mereish et al, 1991).…”