Remember NIBS? tACS improves memory performance in elders with subjective memory complaints

Varastegan, Sahereh; Kazemi, Reza; Rostami, Reza; Khomami, Sanaz; Zandbagleh, Ahmad; Hadipour, Abed L.

doi:10.1007/s11357-022-00677-2

Cited by 14 publications

(6 citation statements)

References 89 publications

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“…Before the BASELINE and after the INTERVENTION block, a 5-min-long resting EEG was recorded, and participants were asked to sit still, relax, and keep their eyes open. This time span has been used in similar studies by other researchers investigating EEG in older adults (Babiloni et al, 2015 ; Scally et al, 2018 ; Rumpf et al, 2019 ; Varastegan et al, 2023 ). During an approximately 2–3-min-long self-paced break (mean 148 s, SD 66 s) between the blocks, the participants were allowed to drink and rest.…”

Section: Methodsmentioning

confidence: 96%

Attempting to counteract vigilance decrement in older adults with brain stimulation

Löffler,

Stecher,

Meiser

et al. 2023

Front. Neuroergonomics

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IntroductionAgainst the background of demographic change and the need for enhancement techniques for an aging society, we set out to repeat a study that utilized 40-Hz transcranial alternating current stimulation (tACS) to counteract the slowdown of reaction times in a vigilance experiment but with participants aged 65 years and older. On an oscillatory level, vigilance decrement is linked to rising occipital alpha power, which has been shown to be downregulated using gamma-tACS.MethodWe applied tACS on the visual cortex and compared reaction times, error rates, and alpha power of a group stimulated with 40 Hz to a sham and a 5-Hz-stimulated control group. All groups executed two 30-min-long blocks of a visual task and were stimulated according to group in the second block. We hypothesized that the expected increase in reaction times and alpha power would be reduced in the 40-Hz group compared to the control groups in the second block (INTERVENTION).ResultsStatistical analysis with linear mixed models showed that reaction times increased significantly over time in the first block (BASELINE) with approximately 3 ms/min for the SHAM and 2 ms/min for the 5-Hz and 40-Hz groups, with no difference between the groups. The increase was less pronounced in the INTERVENTION block (1 ms/min for SHAM and 5-Hz groups, 3 ms/min for the 40-Hz group). Differences among groups in the INTERVENTION block were not significant if the 5-Hz or the 40-Hz group was used as the base group for the linear mixed model. Statistical analysis with a generalized linear mixed model showed that alpha power was significantly higher after the experiment (1.37 μV2) compared to before (1 μV2). No influence of stimulation (40 Hz, 5 Hz, or sham) could be detected.DiscussionAlthough the literature has shown that tACS offers potential for older adults, our results indicate that findings from general studies cannot simply be transferred to an old-aged group. We suggest adjusting stimulation parameters to the neurophysiological features expected in this group. Next to heterogeneity and cognitive fitness, the influence of motivation and medication should be considered.

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Section: Methodsmentioning

confidence: 96%

Attempting to counteract vigilance decrement in older adults with brain stimulation

Löffler,

Stecher,

Meiser

et al. 2023

Front. Neuroergonomics

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“…tACS of 6 Hz and 1 mA for 15 min was applied to the left DLPFC of the subjects, and through the use of a psychomotor vigilance task (PVT) and EEG analysis, it was found that compared with the sham stimulation group, the phase synchronization of the θ band following stimulation was significantly reduced in the true stimulation group, thus adjusting the sustained attention in the cognitive domain [26]. Varastegan et al [27] also subjected 16 elderly individuals with subjective memory complaints (SMC) to 6 Hz tACS, evaluated and recorded using the Rey Auditory-Verbal Learning Test (RAVLT), and found that θ-tACS could improve cognitive components such as event memory in SMC patients through activity in the frontal and temporal regions of the brain. Krebs et al [28] suggested that using 5 Hz θ-tACS to stimulate the left dorsolateral prefrontal cortex in healthy elderly individuals could improve the effectiveness of cognitive training.…”

Section: Application Of Tacs In the Cognitive Domainmentioning

confidence: 99%

Advances in Non-Invasive Neuromodulation Techniques for Improving Cognitive Function: A Review

Chen,

Huang,

Wang

et al. 2024

Brain Sciences

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Non-invasive neuromodulation techniques are widely utilized to study and improve cognitive function, with the aim of modulating different cognitive processes. For workers performing high-intensity mental and physical tasks, extreme fatigue may not only affect their working efficiency but may also lead to cognitive decline or cognitive impairment, which, in turn, poses a serious threat to their physical health. The use of non-invasive neuromodulation techniques has important research value for improving and enhancing cognitive function. In this paper, we review the research status, existing problems, and future prospects of transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), transcranial magnetic stimulation (TMS), and transcutaneous acupoint stimulation (TAS), which are the most studied physical methods in non-invasive neuromodulation techniques to improve and enhance cognition. The findings presented in this paper will be of great reference value for the in-depth study of non-invasive neuromodulation techniques in the field of cognition.

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“…No contexto da reabilitação neuropsicológica, a ETCC tem sido explorada como uma potencial intervenção terapêutica para melhorar as capacidades cognitivas comprometidas em condições neuropsicológicas, como a doença de Alzheimer e o comprometimento cognitivo leve (Boggio et al, 2009;Varastegan et al, 2023).…”

Section: Objetivosunclassified

Estimulação Transcraniana por Corrente Contínua na Cognição e Memória em Idosos

Viana,

Silvestre Junior,

Silva

2024

J. Res. Med and Health

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Introdução: A estimulação transcraniana por corrente contínua (ETCC) representa uma abordagem promissora na reabilitação neuropsicológica, especialmente entre a população idosa. Com o envelhecimento global acelerado, surge a necessidade de enfrentar os desafios relacionados ao declínio cognitivo e à perda de memória, condições prevalentes que comprometem a qualidade de vida dos mais velhos. Objetivo: Analisar os efeitos da ETCC na cognição e memória de idosos, consolidando as descobertas científicas atuais para determinar a eficácia dessa técnica como uma intervenção terapêutica. Métodos: Trata-se de uma revisão de literatura, utilizando artigos científicos nas bases de dados US National Library of Medicine (PubMed) e Scientific Electronic Library Online (SciELO) e Literatura Latino-americana e do Caribe em Ciências da Saúde (LILACS). Foram empregados descritores do DeCS (Descritores em Ciências da Saúde) com o operador booleano "AND", incluindo os termos "Transcranial Direct Current Stimulation", “Cognition”, "Elderly" e "Memory". Textos completos gratuitos, publicados em revistas revisadas por pares, disponíveis em inglês e português, e estudos publicados no período de 2019 a 2024. Resultados: Inicialmente, foram encontrados 28 artigos. Após a aplicação de critérios de inclusão e exclusão, foram selecionados 5 artigos para compor o estudo. Os estudos demonstraram uma tendência positiva, indicando que a ETCC pode melhorar aspectos da função cognitiva e da memória em idosos. De forma geral, os resultados sugerem benefícios potenciais. Conclusão: Apesar dos resultados promissores, é necessário cautela ao interpretar os achados devido à heterogeneidade dos estudos. Porém, parece que a ETCC pode ser uma ferramenta viável para a melhoria cognitiva em idosos.

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Remember NIBS? tACS improves memory performance in elders with subjective memory complaints

Cited by 14 publications

References 89 publications

Attempting to counteract vigilance decrement in older adults with brain stimulation

Attempting to counteract vigilance decrement in older adults with brain stimulation

Advances in Non-Invasive Neuromodulation Techniques for Improving Cognitive Function: A Review

Estimulação Transcraniana por Corrente Contínua na Cognição e Memória em Idosos

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