2008
DOI: 10.1111/j.1399-6576.2007.01566.x
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Remifentanil and the brain

Abstract: The knowledge of the influence of remifentanil on brain functions is crucial before routine use in neuroanesthesia to improve anesthesia performance and patient safety as well as outcome.

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Cited by 71 publications
(46 citation statements)
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“…The short context-sensitive half-life of remifentanil makes this drug a popular analgesic during balanced volatile anaesthesia, 16 and the addition of remifentanil to volatile agents does not seem to modify the BIS level when there is no painful stimulation. 17 The supplemental use of remifentanil did not significantly confound BIS measurements in this study.…”
Section: Discussionmentioning
confidence: 51%
“…The short context-sensitive half-life of remifentanil makes this drug a popular analgesic during balanced volatile anaesthesia, 16 and the addition of remifentanil to volatile agents does not seem to modify the BIS level when there is no painful stimulation. 17 The supplemental use of remifentanil did not significantly confound BIS measurements in this study.…”
Section: Discussionmentioning
confidence: 51%
“…Briefl y, the animal was intubated aft er induction with fentanyl (31 μ g kg − 1 ), thiopental (5 mg kg − 1 ) and succinylcholine chloride (3 mg kg − 1 ), and the anaesthesia throughout the experiment was maintained with remifentanil (0.5 -2 μ g kg − 1 min − 1 ). Remifentanil is the standard μ -opioid that has been used throughout our previous monkey fMRI experiments 10,11,21 because of a number of benefi cial features at these concentrations: little eff ect on cerebral metabolism, negligible eff ects on neuronal excitability (as measured with motor-evoked potentials) and potential neuroprotective eff ects 56 . In our previous microstimulation fMRI experiments 10 , a comparison between the anaesthetized and awake state did not reveal any substantial diff erences in evoked BOLD responses.…”
Section: Methodsmentioning
confidence: 99%
“…Remifentanil has short duration of action which allows earlier emergence and recovery. Moreover remifentanil reduces mean arterial pressure and cerebral perfusion pressure 9 .…”
Section: Introductionmentioning
confidence: 99%