Remineralization Induced by Biomimetic Hydroxyapatite Toothpastes on Human Enamel

Florea, Alexandra-Diana; Pop, Lucian Cristian; Benea, Horea-Rares-Ciprian; Tomoaia, Gheorghe; Racz, Csaba-Pal; Mocanu, Aurora; Dobrota, Cristina-Teodora; Balint, Reka; Soritau, Olga; Tomoaia-Cotisel, Maria

doi:10.3390/biomimetics8060450

Cited by 10 publications

(16 citation statements)

References 70 publications

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“…A number of studies have shown that Coca-Cola ® decreased the salivary pH immediately after consumption [35][36][37]39,40], but generally it did not produce a decrease in salivary pH below 5.5 [35][36][37]. The pH value of 5.5 was found to be critical for enamel dissolution and caries development in vitro [56,61]; at the same time, in vivo this value varies over a wide range depending on the individual characteristics of the enamel and the content of mineral ions in plaque fluid and saliva [73][74][75]. In relation to erosion, critical pH is reversely proportional to the calcium and phosphate concentrations not only in the saliva and plaque fluid, but also in the foods and drinks.…”

Section: Discussionmentioning

confidence: 99%

“…BF active ingredients include Zn-hydroxyapatite and a probiotic. Remineralizing properties of hydroxyapatite are well documented [53][54][55][56]94,95]. Biomimetic (hydroxyapatite-containing) oral care products replicate the natural structure of teeth and can promote the remineralization of hard tooth tissues [53][54][55][56].…”

Section: Discussionmentioning

confidence: 99%

“…Remineralizing properties of hydroxyapatite are well documented [53][54][55][56]94,95]. Biomimetic (hydroxyapatite-containing) oral care products replicate the natural structure of teeth and can promote the remineralization of hard tooth tissues [53][54][55][56]. Particularly hydroxyapatite doped with Zn ions has been found to be an effective agent in mineralizing hard tooth tissues [94][95][96].…”

Section: Discussionmentioning

confidence: 99%

“…Another approach is to use oral care products immediately after acidic exposure. Regarding anti-erosive and remineralizing potential, the most promising results have been reported for fluoride-and hydroxyapatite-containing products [20,[50][51][52][53][54][55][56]. Alkaline oral care products may also be of interest due to their ability to increase salivary pH [57][58][59].…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Oral Care Foams and a Spray on Salivary pH Changes after Exposure to Acidic Beverages in Young Adults

Polyakova,

Egiazaryan,

Doroshina

et al. 2024

Dentistry Journal

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Soft drinks may have a deleterious effect on dental health due to a high titratable acidity and a low pH that could be sufficient to induce tooth demineralization. The use of oral care products immediately after acidic challenge may diminish the erosive potential of soft drinks. We assessed the effect of oral care foams and a spray on salivary pH changes after exposure to Coca-Cola® in young adults. Thirty-three consenting eligible patients were recruited in this double-blind, randomized, crossover study performed in six visits. Baseline examination included unstimulated salivary flow rate, stimulated salivary buffer capacity, and the simplified oral hygiene index (OHI-S) assessment. Salivary pH and time for pH recovery were registered after exposure to Coca-Cola® alone or that followed by the application of each of the studied products (an oral foam containing hydroxyapatite and probiotics, an oral foam containing amino fluoride, an alkaline oral spray, and tap water). Thirty-two patients completed the entire study protocol and were included in the final analysis. The mean minimum salivary pH and the mean oral clearance rate after rinsing with Coca-Cola® were 6.3 and 27 min, respectively. Further rinsing with any one of the tested solutions, including tap water, resulted in a significant improvement in these parameters. When the pH curves were plotted, the oral care products demonstrated a lower area under the curve that differed significantly from the area under the curve for Coca-Cola®; tap water did not differ significantly from Coca-Cola® and oral care products. Minimum salivary pH correlated positively with salivary buffer capacity and salivation rate, while salivary clearance correlated with OHI-S plaque scores. In conclusion, the effect of oral care foams and a spray on minimum salivary pH and salivary clearance after exposure to Coca-Cola® did not differ significantly among the tested products and tap water. Trial registration NCT06148662. Funding: none.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Effect of Oral Care Foams and a Spray on Salivary pH Changes after Exposure to Acidic Beverages in Young Adults

Polyakova,

Egiazaryan,

Doroshina

et al. 2024

Dentistry Journal

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“…atomic force microscopy (AFM) is also a suitable technique for evidencing changes in enamel topography because it can provide more quantitative results on surface roughness. Several articles have been published that use the AFM technology to track erosion and demineralization changes in enamel [47][48][49][50][51][52][53][54][55].…”

Section: Introductionmentioning

confidence: 99%

Dynamics of Dental Enamel Surface Remineralization under the Action of Toothpastes with Substituted Hydroxyapatite and Birch Extract

Dobrota,

Florea,

Racz

et al. 2024

Materials

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To address tooth enamel demineralization resulting from factors such as acid erosion, abrasion, and chronic illness treatments, it is important to develop effective daily dental care products promoting enamel preservation and surface remineralization. This study focused on formulating four toothpastes, each containing calcined synthetic hydroxyapatite (HAP) in distinct compositions, each at 4%, along with 1.3% birch extract. Substitution elements were introduced within the HAP structure to enhance enamel remineralization. The efficacy of each toothpaste formulation was evaluated for repairing enamel and for establishing the dynamic of the remineralization. This was performed by using an in vitro assessment of artificially demineralized enamel slices. The structural HAP features explored by XRD and enamel surface quality by AFM revealed notable restorative properties of these toothpastes. Topographic images and the self-assembly of HAP nanoparticles into thin films on enamel surfaces showcased the formulations’ effectiveness. Surface roughness was evaluated through statistical analysis using one-way ANOVA followed by post-test Bonferroni’s multiple comparison test with a p value < 0.05 significance setting. Remarkably, enamel nanostructure normalization was observed within a short 10-day period of toothpaste treatment. Optimal remineralization for all toothpastes was reached after about 30 days of treatment. These toothpastes containing birch extract also have a dual function of mineralizing enamel while simultaneously promoting enamel health and restoration.

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Investigating the demineralisation of hydroxyapatite by kombucha and hard seltzer using atomic force microscopy

Erickson,

Rond,

Cravens

2024

Biosurface and Biotribology

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While the erosive potential of acidic beverages has been known for decades, many new and increasingly popular beverages and food fads have not been evaluated quantitatively for their dental associated risks. In this study, the authors utilise atomic force microscopy to monitor changes in the surface morphology of an enamel mimic, hydroxyapatite (HA), induced by hard seltzer and kombucha. The primary causes of enamel degradation were assessed through a combinatorial investigation probing the impact of carbonation, acid type, acid concentration, and saliva. The average surface roughness of HA discs was determined after successive demineralisation steps. The heterogeneity of the decay process was assessed using multiple spatial replicates per sample. To aid in the interpretation of the HA decay profiles, pH and titratable acidity of each beverage were also measured. The authors find that, in comparison to a reference sample of Coca‐Cola®, kombucha is equally erosive after prolonged exposure while hard seltzer results in relatively minor surface damage. In addition, the presence of saliva was found to eliminate any measurable amounts of decay. Results from this study demonstrate the potential damage more recently popularised beverages can have on dental enamel and the significant dependence of oral health on the presence of saliva.

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Remineralization Induced by Biomimetic Hydroxyapatite Toothpastes on Human Enamel

Cited by 10 publications

References 70 publications

The Effect of Oral Care Foams and a Spray on Salivary pH Changes after Exposure to Acidic Beverages in Young Adults

The Effect of Oral Care Foams and a Spray on Salivary pH Changes after Exposure to Acidic Beverages in Young Adults

Dynamics of Dental Enamel Surface Remineralization under the Action of Toothpastes with Substituted Hydroxyapatite and Birch Extract

Investigating the demineralisation of hydroxyapatite by kombucha and hard seltzer using atomic force microscopy

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