Remineralization Potential of Grape Seed Extract Versus Fluoride Mouthwash in Management of Post-Orthodontic White Spot Lesions: A 6m Randomized Clinical Trial

Abstract

Aim:This study compared the remineralization potential of grape seed extract vs sodium fluoride mouthwash in adult patients with postorthodontic white spot lesions assessed with DIAGNOdent after six months. Materials and methods: A total of 14 participants with 40 lesions received mouthwashes randomly using either; grape seed extract 15% or sodium fluoride (1000 ppm), the participants were asked to use the mouthwash twice daily. The teeth were evaluated with DIAGNOdent after 1, 3 & 6 months. After 6 months, patient satisfaction was also recorded by using a binary questionnaire.Results: Regarding DIAGNOdent scores, 6 months intergroup comparisons revealed statistically significant differences (P=0.0198) for grape seed extract, and a statistically significant difference between different follow-up periods was found in intragroup comparisons within grape seed extract or sodium fluoride (P=0.0001). Regarding patient satisfaction, after 6 months, there was no statistically significant difference between the two materials (P = 0.5302). Conclusion: Both mouthwashes showed a potential remineralizing effect on post-orthodontic white spot lesions in the early testing periods, while grape seed extract mouthwash has a beneficial influence after 6 months. Clinical significance: Using grape seed extract as a natural remineralizing agent to treat early enamel carious lesions has the potential to be a viable approach.