Remineralizing Effect of Casein Phosphopeptide–Amorphous Calcium Phosphate and Sodium Fluoride on Artificial Tooth Enamel Erosion: An In Vitro Study

Abstract

Aim: To compare in vitro the remineralizing effect of toothpastes with casein phosphopeptide-amorphous calcium phosphate (FPC-FCA) and sodium fluoride on the artificial erosion of tooth enamel. Materials and methods: For the first phase of artificial erosion, group I was considered as the control group without treatment or erosion. For groups II and IV, the drink was used (Coca-Cola®), for groups III and V, the drink (Inca-Kola®), and the four groups were demineralized four times a day (every 3 hours for 2 minutes) for 5 days. In the treatment phase in groups II and III, brushing was performed with sodium fluoride paste (Colgate®), groups IV and V received brushing with FPC-FCA complex (MiPaste®), and for all groups, the same procedure was performed four times a day (every 3 hours for 5 minutes) for 90 days. At the end, the microroughness of the surfaces of all the groups was evaluated by means of a Rugosimeter (Mitutoyo). Results: It was evidenced that the group of sodium fluoride presented a microroughness of 2.79 μm being the group of least remineralization, but the FPC-FCA complex showed a microroughness of 1.96 μm; however, the control group presented a microroughness of 3.20 μm, and the groups sodium fluoride, FPC-FCA compared to the control group proved to be statistically significant with a p < 0.05. Conclusion:The remineralizing effect of FPC-FCA (MiPaste®) complex proved to be greater than sodium fluoride paste (Colgate®) under artificial enamel erosive conditions. Clinical importance: The results of this research serve as a basis for industries to generate products that have the potential for remineralization against various erosive beverages that are consumed daily.

The effect of two calcium phosphate‐containing agents on the enamel resistance of permanent molars to demineralization: An experimental study

“…Different studies on the application of CPP-ACP, that is, GC tooth mousse™ in the current study, have shown to cause an increase in calcium/phosphorus (Ca/P) ratio in tooth enamel (Mettu et al, 2015), slow progress of caries in initial lesions (Llena et al, 2009), and potential enamel remineralization capability (Pirca et al, 2019).…”

“…Therefore, the use of calcium phosphate‐containing agents has been recently introduced as a preventive method, for example, the application of calcium phosphate powders/chewing gums/varnishes, specifically and casein phosphopeptide amorphous calcium phosphate complexes (CPP–ACP, e.g., GC tooth mousse™) (Meyer‐Lueckel et al, 2015 ) and Remin Pro® (Nourolahian et al, 2021 ). Different studies on the application of CPP‐ACP, that is, GC tooth mousse™ in the current study, have shown to cause an increase in calcium/phosphorus (Ca/P) ratio in tooth enamel (Mettu et al, 2015 ), slow progress of caries in initial lesions (Llena et al, 2009 ), and potential enamel remineralization capability (Pirca et al, 2019 ). Moreover, CPP‐ACP and fluoride have demonstrated a possible synergistic effect against caries associated with an increased remineralization ability in superficial carious lesions (Bayrak et al, 2017 ).…”

Influence of Coca-Cola on orthodontic materials. A systematic review

“…2). This contrasts with the significantly larger number of investigations, including in vivo studies, on the effect of colaflavored drinks on enamel erosion (e.g., Tenuta et al 2015;Yu et al 2018;Pirca et al 2019).…”

Current trends and spatial-temporal dynamics of veterinary dentistry research: A scientometric study

“…This study explored recent advances in veterinary dentistry, emphasizing the essential role of dental prevention and treatment [22,23] in animal welfare. By analyzing current challenges, from the lack of awareness to restrictions in access to specialized services, this study sought solutions and strategies to improve dental care for animals, thus contributing to a healthier and happier life for our pets.…”