Remission of human immunodeficiency virus-related lymphoma in association with immune reconstitution on anti-retroviral therapy, without chemotherapy

Spontaneous Regression of Epstein-Barr Virus-Positive Diffuse Large B-cell Lymphoma in an HIV-Positive Patient: A Case Report and Literature Review

“…Besides that, the use of herbal medicines has been postulated to contribute to the spontaneous regression of tumors as well due to their anti-inflammatory properties [18,19]. To our knowledge, the underpinning mechanism through which HIV-associated lymphomas experience spontaneous regression is most likely due to the immune reconstitution effects of cART [7][8][9][12][13][14][15][16][17]. All patients had markedly increased CD4 counts at remission and significantly reduced HIV viral load, which further strengthens this theory.…”

“…From our literature review, we have also identified another six cases of biopsy-proven lymphomas that responded to cART alone and these are summarized in Table 1 [12][13][14][15][16][17]. Patients reported by Sindhu et al [7] and Griffin et al [8] have been excluded from our study cohort as well as those who received some form of conventional cancer therapy concurrently with the administration of cART. a : EFV was switched to RAL approximately after one month.…”

Stage IV advanced diffuse large B-cell lymphoma in human immunodeficiency virus infection with achieving cure by using highly active antiretroviral therapy alone: a case report

“…Although several cases of low-grade lymphoma with complete regression were reported, we can find only 10 systemic DLBCL cases (except primary CNS lymphoma) that showed remission in patients receiving HAART without chemotherapy or radiotherapy. 6–10…”

“…The follow-up periods of 9 of the 10 reported cases were less than 5 years (from 9 months to 39 months). One case had a follow-up period over 5 years with a disease-free period of 191 months, but had no information of disease stage and IPI 10 (Table 1). For diffuse large B-cell NHL patients with complete remission, the guidelines propose follow-up every 3 months for 24 months then every 6 months for 36 months.…”

“…It is clear that the use of HAART protects against the development of HIV-related NHL and improves outcomes. 5–10,14,15 Lymphoma immune reconstitution inflammatory syndrome (IRIS) in AIDS under HAART was reported in one retrospective cohort study. 16 They reported that patients infected with HIV have increased incidence of malignant lymphoma during the first 6 months after HAART (median 2.2 months).…”