Remission of Psoriasis after Open Gastric Bypass

Ettinger, João Eduardo Marques Tavares de Menezes; Ázaro, Euler; Souza, Carlos Alfredo Marcílio de; Filho, Paulo Vicente dos Santos; Mello, Carlos Augusto Bastos; Neves, Murilo Catafesta das; Amaral, Paulo Cezar Galvão de; Fahel, Edvaldo

doi:10.1381/096089206775221998

Cited by 80 publications

(57 citation statements)

References 22 publications

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“…In obese patients, there is a significant positive correlation between serum levels of TNF-α and waist-hip ratio, serum levels of soluble TNF-α receptor 1 and body weight, and soluble TNF-α receptor 2 and BMI [29,30,31]. It has been documented that fasting may improve, at least temporarily, inflammatory conditions including psoriasis [32, 33] and there are case reports of psoriasis remission after surgery for obesity [34]. …”

Section: Discussionmentioning

confidence: 99%

Impact of Body Mass Index and Obesity on Clinical Response to Systemic Treatment for Psoriasis

et al. 2008

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Objective: Our aim was to assess the role of the body mass index (BMI) in the clinical response to systemic treatment for psoriasis. Methods: A nationwide cohort study of patients receiving a new systemic treatment for plaque psoriasis at reference centres in Italy was conducted. Information was gathered through a web-based electronic form. Patients being maintained on the same medication and with data available at 8 and 16 weeks by March 31, 2007, were eligible. The outcome was a reduction in the Psoriasis Area Severity Index (PASI) of at least 75% at follow-up compared to baseline (PASI-75). Results: Out of 8,072 patients enrolled, 2,368 were eligible and analysable at 8 weeks and 2,042 at 16 weeks. PASI-75 was achieved by 819 patients (34.5%) at 8 weeks and 1,034 (50.6%) at 16 weeks. The proportion steadily decreased with increased values of BMI. Compared to normal weight (BMI = 20–24) the adjusted odds ratio for achieving PASI-75 in obese patients was 0.73 (95% CI = 0.58–0.93) at 8 weeks and 0.62 (95% CI = 0.49–0.79) at 16 weeks. The impact of the BMI did not show remarkable variations according to the drug prescribed at entry. Conclusion: The BMI affects the early clinical response to systemic treatment for psoriasis.

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Section: Discussionmentioning

confidence: 99%

Impact of Body Mass Index and Obesity on Clinical Response to Systemic Treatment for Psoriasis

et al. 2008

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“…The relationship between weight loss and psoriasis severity remains to be elucidated, but several case studies have shown that weight loss from gastric bypass surgery results in remission of psoriasis. 45,46 Depression Depression is associated with increased risk of cardiovascular disease. 47,48 Psoriasis is associated with lack of self-esteem and increased prevalence of mood disorders including depression.…”

Section: Obesitymentioning

confidence: 99%

National Psoriasis Foundation clinical consensus on psoriasis comorbidities and recommendations for screening

Kimball

Gladman

Gelfand

et al. 2008

Journal of the American Academy of Dermatology

381

321

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“…There are case reports of complete remission of severe psoriasis with the discontinuation of all psoriasis medications after substantial weight loss as a result of gastric bypass surgery [14,15,16]. More recently, it has been shown that obese patients with moderate-to-severe psoriasis increase their response to low-dose cyclosporine if calorie-controlled diet is included in the treatment regimen [17].…”

Section: Introductionmentioning

confidence: 99%

Weight Reduction Alone May Not Be Sufficient to Maintain Disease Remission in Obese Patients with Psoriasis: A Randomized, Investigator-Blinded Study

Giglio

Gisondi²,

Tessari³

et al. 2012

Dermatology

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Background: The relative risk of psoriasis and its severity are directly related to the body mass index. Objective: To investigate the effects of a hypoenergetic diet to maintain disease remission in obese patients. Methods: A questionnaire was administered to 200 patients with moderate-to-severe chronic plaque psoriasis asking whether diet could influence psoriasis severity. Forty-two obese patients in remission (PASI improvement ≥75%) for at least 12 weeks after methotrexate therapy were randomly assigned to receive a hypocaloric diet or free diet for 24 weeks, and were then followed up for an additional 12 weeks. Results: Most of the patients considered that a diet regimen could influence their psoriasis, and desired to enter a dietary program. Obese patients who were in disease remission and entered a hypocaloric diet regimen showed a significant body weight reduction after 12 weeks which was maintained at week 24. However, patients under hypocaloric and free diets did not significantly differ in the maintenance of psoriasis remission, with relapse observed already at week 12, but with a trend in favor of the intervention group. Conclusions: Body weight reduction alone may not be sufficient for maintaining remission of moderate-to-severe psoriasis in obese patients.

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Remission of Psoriasis after Open Gastric Bypass

Cited by 80 publications

References 22 publications

Impact of Body Mass Index and Obesity on Clinical Response to Systemic Treatment for Psoriasis

Impact of Body Mass Index and Obesity on Clinical Response to Systemic Treatment for Psoriasis

National Psoriasis Foundation clinical consensus on psoriasis comorbidities and recommendations for screening

Weight Reduction Alone May Not Be Sufficient to Maintain Disease Remission in Obese Patients with Psoriasis: A Randomized, Investigator-Blinded Study

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