The relevance of the subject of this study is due to the situation and negative trends in Ukrainian small business, the importance and number of this type of business entities, and institutional constraints on business activities, which requires increasing its effectiveness and efficiency through sustainable development. The purpose of the paper is to develop theoretical-methodological foundations, scientificmethodical and practical recommendations for the development of small business in Ukraine. To obtain specific scientific results both general scientific and specific methods of study were used: a complex of economic-statistical and economic-mathematical methods of analysis and modeling. The state and tendencies of development of national small business were analyzed. Based on the obtained results the comparative analysis of specifics of small business in Ukraine was carried out. The strategic priorities of small business development of Ukraine were substantiated, which observance will promote growth of national economy and will allow to clearly identify necessary areas of support for small business entities in the course of development and implementation of programs of development of small business at various levels of management. The basis for the development of national and regional strategies for small business development should be not only regulatory and legal support, but also previous positive experience, in particular, on the implementation of strategic projects for small business development in leading European countries, regions and separate cities. The fact that in Ukraine small business is not yet given due attention, there is no clear concept and in fact the declared strategy of its development is not implemented, proves the need to develop small business and reflect this in the development of a strategy.