Remitting seronegative symmetrical synovitis with pitting oedema: disease or syndrome?

Schaeverbeke, Thierry; Fatout, E.; Marce, S.; Vernhes, J P; Hallé, O; Antoine, J F; Lequen, L.; Bannwarth, B; Dehais, J.

doi:10.1136/ard.54.8.681

Cited by 69 publications

(41 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although clinical examination usually allows for diagnosis of RS3PE, Schaeverbeke et al (15) reported that RS3PE was diagnosed retrospectively in 9 of 24 patients. The diagnostic gap between determination of RS3PE and clinical findings requires imaging to establish the final diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Remitting seronegative symmetrical synovitis with pitting edema of the hands: Ultrasound, color doppler ultrasound, and magnetic resonance imaging findings

Klauser¹,

Frauscher²,

Halpern³

et al. 2005

Arthritis & Rheumatism

View full text Add to dashboard Cite

Objective. To assess the value of gray-scale ultrasound (US), color Doppler ultrasound (CDUS), contrast-enhanced CDUS, and magnetic resonance imaging (MRI) in the diagnostic evaluation of the hands in patients with remitting seronegative symmetrical synovitis with pitting edema (RS3PE). Methods. Eight patients (5 men, 3 women; mean ؎ SD age 69.3 ؎ 7.2 years) with clinical diagnosis of RS3PE syndrome underwent US, CDUS, contrast-enhanced CDUS, and MRI. US was performed with a linear array transducer operating at 12 MHz. The US contrast agent (SHU 508; Levovist, Schering, Germany) was intravenously infused in a concentration of 300 mg/ml at a rate of 1 ml/minute. Results. All patients showed symmetric subcutaneous edema and synovitis of tendons and finger joints on both US and MRI. Vascularity was detected subcutaneously in tendon sheaths and in the joint synovia on CDUS and MRI. Detection of increased vascularity was improved after contrast administration compared with unenhanced CDUS (P < 0.01). Conclusion. Ultrasound, CDUS, contrast-enhanced CDUS, and MRI are valuable tools in the diagnostic evaluation of involved anatomic structures in patients with RS3PE. Contrast-enhanced CDUS is superior to CDUS in assessment of inflammatory edema, effusion, and synovitis.

show abstract

Section: Discussionmentioning

confidence: 99%

Remitting seronegative symmetrical synovitis with pitting edema of the hands: Ultrasound, color doppler ultrasound, and magnetic resonance imaging findings

Klauser¹,

Frauscher²,

Halpern³

et al. 2005

Arthritis & Rheumatism

View full text Add to dashboard Cite

show abstract

“…Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) is characterized by symmetrical synovitis predominantly involving the hands with pitting edema of the dorsum of the hands (Schaeverbeke et al 1995). Patients have been found to respond well to low dose corticosteroids and to remain in remission (Paira et al 2002).…”

Section: Introductionmentioning

confidence: 99%

Myelodysplastic Syndrome Precedes the Onset of Remitting Seronegative Symmetrical Synovitis with Pitting Edema (RS3PE) Syndrome

Matsunaga

Izumi

Iwanaga

et al. 2015

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Remitting seronegative symmetrical synovitis with pitting edema (RS3PE) syndrome is characterized by symmetrical synovitis predominantly involving the wrists, and is associated with marked pitting edema of the dorsum of the hands. Although the etiology of RS3PE syndrome is still unknown, several putative associations with malignancies and hematological disorders have been reported. Myelodysplastic syndrome (MDS) is characterized by infective hematopoiesis with possible transformation to leukemia; however, an association between RS3PE syndrome and MDS has been rarely reported. Here, we describe a 67-year-old man with MDS with refractory anemia who developed RS3PE syndrome 3 months after the diagnosis of MDS. The patient presented with polyarthritis with pitting edema at the dorsum of the hands, the elevated serum levels of C-reactive protein and a proinflammatory cytokine, interleukin-6, and the elevated plasma levels of vascular endothelial growth factor (VEGF). VEGF has been shown to be involved in the pathogenesis of RS3PE syndrome. Treatment with low doses of corticosteroids resulted in the regression of polyarthritis and pitting edema of the dorsum of the hands, as well as a reduction in the elevated levels of plasma VEGF. Partial resolution of refractory anemia was also observed with steroid therapy. In summary, RS3PE syndrome developed shortly after MDS was identified in this patient. The sequence of clinical events suggests that MDS-mediated immunological abnormalities including inflammatory cytokine induction may be responsible for the association between MDS and RS3PE syndrome. Patients with RS3PE syndrome should be screened for hematological disorders that promote proinflammatory mediators.

show abstract

“…2 There are also reports of RS3PE in association with most other rheumatological conditions, including rheumatoid arthritis, spondyloarthropathies, psoriatic arthritis and PMR. 3 Cases of PMR often have distal signs and more frequently distal relapses. Therefore, RS3PE has been hypothesised to be part of a spectrum of PMR, although RS3PE does not require such high doses of steroids.…”

Section: Discussionmentioning

confidence: 99%

A patient with recurrent oedema of the hands and a collapse

2011

View full text Add to dashboard Cite

Remitting seronegative symmetrical synovitis with pitting oedema: disease or syndrome?

Cited by 69 publications

References 10 publications

Remitting seronegative symmetrical synovitis with pitting edema of the hands: Ultrasound, color doppler ultrasound, and magnetic resonance imaging findings

Remitting seronegative symmetrical synovitis with pitting edema of the hands: Ultrasound, color doppler ultrasound, and magnetic resonance imaging findings

Myelodysplastic Syndrome Precedes the Onset of Remitting Seronegative Symmetrical Synovitis with Pitting Edema (RS3PE) Syndrome

A patient with recurrent oedema of the hands and a collapse

Contact Info

Product

Resources

About