Remnant B-cell-stimulative and anti-oxidant effects of &lt;i&gt;Persea americana&lt;/i&gt; fruit extract studied in rats introduced into streptzotocin-induced hyperglycaemic state

Rao, U.S. Mahadeva; Adinew, Bizuneh

doi:10.4314/ajtcam.v8i3.65277

Cited by 29 publications

(38 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In rats, phenolic extracts of avocado (from leaves and fruits) inhibited the activity of enzymes related to the development of T2DM (α-amilase and α-glucosidase), as well as the malondialdehyde production (MDA), a marker of oxidative stress and responsible for increasing the lipid peroxidation [17]. The hypoglycemic effect of the avocado was also related to its ability to stimulate the remaining pancreatic β-cells in animal models, making them able to secrete more insulin [18].…”

Section: Avocado and Type 2 Diabetes Mellitusmentioning

confidence: 99%

Avocado and Cardiovascular Health

Weschenfelder¹,

Santos²,

Souza³

et al. 2015

OJEMD

View full text Add to dashboard Cite

Avocado is a fruit which had a caloric density of 1.7 kcal per gram and a half unit (~70 g) is composed by 114 kcal, 4.6 g of fibers, 345 mg of potassium, 19.5 mg of magnesium, 1.3 mg of vitamin E and 57 mg of phytosterols. Approximately 75% of fiber's avocado contents are considered insoluble and 25% are soluble. The avocado contains lipids that consist of 71% from monounsaturated fatty acids (MUFA), 13% from polyunsaturated (PUFA) and 16% from saturated fatty acids (SFA). Recent researches have shown that avocado may improve hypercholesterolemia and may be useful in the treatment of hypertension and type 2 diabetes mellitus (T2DM). This way, avocado plays an important role in the cardiovascular health. This review summarizes the potential benefits of avocado consumption in the prevention of cardiovascular risk factors and metabolic diseases.

show abstract

Section: Avocado and Type 2 Diabetes Mellitusmentioning

confidence: 99%

Avocado and Cardiovascular Health

Weschenfelder¹,

Santos²,

Souza³

et al. 2015

OJEMD

View full text Add to dashboard Cite

show abstract

“…Generally, tomato and avocado extracts showed significant decrease in lipid peroxidation, compared to that for Hcy. In the same view, determination of thiobarbituric acid reactive cubstances (TBARS), hydroperoxides, and both enzymatic and non-enzymatic antioxidants [29], confirmed the anti-oxidative potential of Avocado fruit extract.…”

Section: Effects On Lipid Peroxidationmentioning

confidence: 67%

“…By the end of the experiment, mixture and broccoli significant decreased total billirubin (0.42 mg dL -1 35%, 0.44 mg dL -1 32%, respectively), and GPT (29.55,29.63 units mL -1 , respectively). LDL/HDL or risk factor has been declined significantly with broccoli extract (91%-0.04 mg dL -1 ).…”

Section: Introductionmentioning

confidence: 94%

“…Rao and Adinew [29] stated that anti-oxidative effects of Persea americana fruit extract were evaluated. Ethanol extract of P. americana, in the concentration of 300 mg/Kg body weight daily, was orally administered to rats introduced into Stz-induced hyperglycaemic state, for a period of 30 days.…”

Section: Effects On Lipid Peroxidationmentioning

confidence: 99%

“…Rao and Adinew [29] stated that ethanol extract of P. americana, in the concentration of 300 mg/Kg body weight daily, after the treatment with Avocado fruit extract, the elevated levels of blood glucose, blood Values which do not share the same letter in each column are significantly different. Values which do not share the same letter in each column are significantly different.…”

Section: Effects On Urea and Creatinine (Kidney Functions)mentioning

confidence: 99%

See 2 more Smart Citations

Hypo-Homocysteinemia Effect for Some Ethanolic Plant Extracts

Shaker¹,

Manaa²,

Mubarak³

et al. 2013

J Nutr Food Sci

View full text Add to dashboard Cite

Recently, elevated plasma homocysteine (Hcy) levels have been impilicated as a risk factor for atherosclerosis, resulting in coronary artery disease, cerebrovascular disease, and peripheral vascular disease. Elevation of plasma homocysteine has been gradually induced subcutenous s.c. for male albino rats, beginning from the 5 th day, and up to three weeks. Oxidative stress is known as one of the mechanisms in injury for Hcy induction. Fruits and vegetables have been proved in lowering the Hcy effects. Fourty two male rats were divided individually into 7 groups as followed: control, Hcy group, Hcy administration with avocado, broccoli, lettuce, tomato and mixture ethanolic extracts (50 gm 100 ml -1 ).Hcy gradually administrated for groups 2-7 (0.3, 0.4, and 0.6 µmoL g -1 body weight), beginning from 5 th day for one week, second and third week, respectively. In the first two weeks, groups 3-7 were fed on basal diet with 0.1 ml oral inj. (per rat weighted 150 gm) avocado, broccoli, lettuce, tomato and mixture extracts.HPLC results showed remarkable Hcy concentrations with avocado, mixture and lettuce extracts; 1.8 and 2.8 and 2.9 µg mL -1 , respectively. By the end of the experiment, mixture and broccoli significant decreased total billirubin (0.42 mg dL -1 35%, 0.44 mg dL -1 32%, respectively), and GPT (29.55,29.63 units mL -1 , respectively). LDL/HDL or risk factor has been declined significantly with broccoli extract (91%-0.04 mg dL -1 ). Creatinine (0.29 mg dL -1 , 50%) and urea (29.63 mg dL -1 , 29%) showed significant improvement with tomato extract comparing to infected group. Avocado showed significant antioxidative activity or reduction in MDA (7.13 nmol mL -1 , 50%).

show abstract