Remnant Cholesterol and the Risk of Coronary Artery Disease in Patients With Type 2 Diabetes

Wang, Kexin; Ding, Yaodong; Wu, Rui; Yang, Jiaxin; Liu, Xiaoli; Han, Hongya; Shen, Hua; Sun, Yan; Zhou, Yujie; Ge, Hailong

doi:10.1177/00033197221121008

Cited by 4 publications

(2 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Studies 10 have reported that high RC level is positively correlated with the occurrence and severity of retinopathy in patients with T2DM. Wang et al 25 also find that RC could increase the risk of cardiovascular disease, especially in patients with T2DM. Sheng et al 11 suggest that unconventional lipid parameters have higher diagnostic performance for future diabetes risk than conventional lipid parameters and both TG/HDL‐C and TC/HDL‐C are great indicators for predicting the occurrence of diabetes.…”

Section: Discussionmentioning

confidence: 95%

Association of remnant cholesterol and newly diagnosed early‐onset type 2 diabetes mellitus in Chinese population: A retrospective cross‐sectional study

Dong,

Yan,

Chen

et al. 2023

Journal of Diabetes

View full text Add to dashboard Cite

BackgroundWith the increasing incidence of diabetes worldwide, patients diagnosed with diabetes has been getting younger. Previous studies have shown that high remnant cholesterol (RC) level leads to an increased risk of cardiovascular disease events. However, the relationship between RC levels and newly diagnosed early‐onset type 2 diabetes mellitus (T2DM) is unknown. This study aimed to explore the association between RC and newly diagnosed early‐onset T2DM.MethodsA total of 606 patients newly diagnosed with early‐onset T2DM and 619 gender‐matched subjects with normal blood glucose levels were retrospectively enrolled in this study. All T2DM patients showed onset age of 18–40 years. Binary logistic regression analysis was performed to analyze independent risk factors and receiver operating characteristic (ROC) analysis was used to explore the predictive value of RC and other unconventional lipids. Moreover, the correlation between RC and insulin resistance in patients with newly diagnosed early‐onset T2DM was also examined with binary logistic regression analysis and Spearman correlation analysis.ResultsIncreased RC level was an independent risk factor for early‐onset T2DM (p < .05). The area under the curve on ROC analysis of RC was 0.805, 95% confidence interval (CI) was 0.781 ~ 0.826, sensitivity was 82.18% and specificity was 66.24%, which showed higher predictive value than those of triglyceride/high‐density lipoprotein cholesterol (TG/HDL‐C) ratio and total cholesterol (TC)/HDL‐C ratio. Cutoff value of RC was 0.32 mmol/L. Level of RC in early‐onset T2DM patients with moderate or severe insulin resistance was significantly higher than that in patients with mild insulin resistance (p < .0001). No difference in RC levels was found between patients with moderate and severe insulin resistance (p > .05). RC was still correlated with insulin resistance after adjusting the conventional lipid parameters (TG, TC, HDL‐C, and low‐density lipoprotein cholesterol) using partial correlation analysis.ConclusionRC level was higher in patients with early‐onset T2DM and was correlated to the degree of insulin resistance as well. Patients aged 18–40 years with RC >0.32 mmol/L showed an increased risk of developing T2DM.

show abstract

Section: Discussionmentioning

confidence: 95%

Association of remnant cholesterol and newly diagnosed early‐onset type 2 diabetes mellitus in Chinese population: A retrospective cross‐sectional study

Dong,

Yan,

Chen

et al. 2023

Journal of Diabetes

View full text Add to dashboard Cite

show abstract

“…In a study of 4145 patients with type 2 diabetes, after multivariate logistic analyses, the level of plasma remnant cholesterol was significantly and independently associated with CAD (OR: 13.524; 95% CI: 7.058–25.912; p < 0.001) after adjustment for conventional risk factors, such as age, gender, hypertension, and other lipid levels [ 95 ].…”

Section: Remnant Lipoproteinsmentioning

confidence: 99%

Atherogenic Lipoproteins for the Statin Residual Cardiovascular Disease Risk

Yanai

Adachi

Hakoshima

et al. 2022

IJMS

View full text Add to dashboard Cite

Randomized controlled trials (RCTs) show that decreases in low-density lipoprotein cholesterol (LDL-C) by the use of statins cause a significant reduction in the development of cardiovascular disease (CVD). However, one of our previous studies showed that, among eight RCTs that investigated the effect of statins vs. a placebo on CVD development, 56–79% of patients had residual CVD risk after the trials. In three RCTs that investigated the effect of a high dose vs. a usual dose of statins on CVD development, 78–87% of patients in the high-dose statin arms still had residual CVD risk. The risk of CVD development remains even when statins are used to strongly reduce LDL-C, and this type of risk is now regarded as statin residual CVD risk. Our study shows that elevated triglyceride (TG) levels, reduced high-density lipoprotein cholesterol (HDL-C), and the existence of obesity/insulin resistance and diabetes may be important metabolic factors that determine statin residual CVD risk. Here, we discuss atherogenic lipoproteins that were not investigated in such RCTs, such as lipoprotein (a) (Lp(a)), remnant lipoproteins, malondialdehyde-modified LDL (MDA-LDL), and small-dense LDL (Sd-LDL). Lp(a) is under strong genetic control by apolipoprotein (a), which is an LPA gene locus. Variations in the LPA gene account for 91% of the variability in the plasma concentration of Lp(a). A meta-analysis showed that genetic variations at the LPA locus are associated with CVD events during statin therapy, independent of the extent of LDL lowering, providing support for exploring strategies targeting circulating concentrations of Lp(a) to reduce CVD events in patients receiving statins. Remnant lipoproteins and small-dense LDL are highly associated with high TG levels, low HDL-C, and obesity/insulin resistance. MDA-LDL is a representative form of oxidized LDL and plays important roles in the formation and development of the primary lesions of atherosclerosis. MDA-LDL levels were higher in CVD patients and diabetic patients than in the control subjects. Furthermore, we demonstrated the atherogenic properties of such lipoproteins and their association with CVD as well as therapeutic approaches.

show abstract

Trajectories of Remnant Cholesterol are Associated with Diabetic Foot Ulcer in Adult Patients with Type 2 Diabetes: A Retrospective Cohort Study

Cao,

Li,

et al. 2024

DMSO

View full text Add to dashboard Cite

Objective This study aimed to investigate the potential association between long-term variations in remnant cholesterol (RC) levels and the development of diabetic foot ulcers (DFU) in participants with type 2 diabetes (T2D). Methods This was a retrospective cohort study. Variation in RC was assessed by the following metrics: mean, standard deviation (SD), coefficient of variation (CV) and trajectories pattern of RC. To identify RC trajectories, we employed the latent class mixture model. The primary endpoint was the development of DFU, and the time-to-event data were analyzed using Cox regression. Results A total of 1874 patients with T2D were included, with a median follow-up duration of 4.7 years. Among them, 129 individuals (6.9%) developed DFU. The proportion of DFU was significantly higher in the U-shaped group compared to the median group (P for trend < 0.001). Upon adjustment for confounding variables, the U-shaped trajectory correlated with a higher risk of DFU, demonstrating a hazard ratio (HR) of 2.57 (95% CI, 1.54–4.27). Subgroup analysis showed the U-shaped trajectory had a higher DFU risk regardless of gender (HR=2.40 and 2.81, respectively), glycemic control (HR=1.89 and 7.41, respectively), smoking (HR=2.36 and 2.93, respectively), or hypertension (HR=2.30 and 2.97, respectively). No association was found between mean, SD and CV of RC and DFU. Conclusion A U-shape trajectory of RC was independently associated with an elevated risk of DFU among patients with T2D.

show abstract

Remnant Cholesterol and the Risk of Coronary Artery Disease in Patients With Type 2 Diabetes

Cited by 4 publications

References 40 publications

Association of remnant cholesterol and newly diagnosed early‐onset type 2 diabetes mellitus in Chinese population: A retrospective cross‐sectional study

Association of remnant cholesterol and newly diagnosed early‐onset type 2 diabetes mellitus in Chinese population: A retrospective cross‐sectional study

Atherogenic Lipoproteins for the Statin Residual Cardiovascular Disease Risk

Trajectories of Remnant Cholesterol are Associated with Diabetic Foot Ulcer in Adult Patients with Type 2 Diabetes: A Retrospective Cohort Study

Contact Info

Product

Resources

About