Remodeling of Left Ventricular Hypertrophy in Elite Athletes After Long-Term Deconditioning

Pelliccia, Antonio; Maron, Barry J.; Luca, Rosanna De; Paolo, Fernando M. Di; Spataro, Antonio; Culasso, Franco

doi:10.1161/hc0802.104534

Cited by 323 publications

(244 citation statements)

References 32 publications

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“…17,[29][30][31][32] For example, in elite athletes, cardiac dimensions do not completely regress to normal levels even several years after the athlete has retired from competition and heavy ET. 33 …”

Section: Athlete's Heartmentioning

confidence: 99%

Potential Adverse Cardiovascular Effects From Excessive Endurance Exercise

O’Keefe

Patil

Lavie

et al. 2012

Mayo Clinic Proceedings

340

305

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A routine of regular exercise is highly effective for prevention and treatment of many common chronic diseases and improves cardiovascular (CV) health and longevity. However, long-term excessive endurance exercise may induce pathologic structural remodeling of the heart and large arteries. Emerging data suggest that chronic training for and competing in extreme endurance events such as marathons, ultramarathons, ironman distance triathlons, and very long distance bicycle races, can cause transient acute volume overload of the atria and right ventricle, with transient reductions in right ventricular ejection fraction and elevations of cardiac biomarkers, all of which return to normal within 1 week. Over months to years of repetitive injury, this process, in some individuals, may lead to patchy myocardial fibrosis, particularly in the atria, interventricular septum, and right ventricle, creating a substrate for atrial and ventricular arrhythmias. Additionally, long-term excessive sustained exercise may be associated with coronary artery calcification, diastolic dysfunction, and large-artery wall stiffening. However, this concept is still hypothetical and there is some inconsistency in the reported findings. Furthermore, lifelong vigorous exercisers generally have low mortality rates and excellent functional capacity. Notwithstanding, the hypothesis that long-term excessive endurance exercise may induce adverse CV remodeling warrants further investigation to identify at-risk individuals and formulate physical fitness regimens for conferring optimal CV health and longevity.

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Section: Athlete's Heartmentioning

confidence: 99%

Potential Adverse Cardiovascular Effects From Excessive Endurance Exercise

O’Keefe

Patil

Lavie

et al. 2012

Mayo Clinic Proceedings

340

305

View full text Add to dashboard Cite

show abstract

“…Training certainly influences sports-relevant physiological attributes dramatically [124][125][126][127] .…”

Section: Box 2: Motivationmentioning

confidence: 99%

Inside the brain of an elite athlete: the neural processes that support high achievement in sports

2009

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“…A decade later, Pelliccia et al examined 40 elite male athletes with eccentric left ventricular hypertrophy (LV chamber diameter = 61.2 mm, LV wall thickness = 12.0±1.3 mm, LV mass = 194 g/m) after more extensive detraining (5.6±3.8 years). 24 In this setting, both left ventricular mass (14021 g/m) and wall thickness (10.10.8 mm) returned to normal values in all athletes while persistent left ventricular cavity dilation remained in 22% of the cohort. Although further confirmation is required, this study suggests that some aspects of exercise-induced cardiac remodeling (i.e.…”

Section: Myocardial Adaptations To Exercisementioning

confidence: 75%