Remodeling the Tumor Microenvironment with Core–Shell Nanosensitizer Featuring Dual-Modal Imaging and Multimodal Therapy for Breast Cancer

Abstract

To improve the efficiency of radiation therapy (RT) for breast cancer, a designable multifunctional core–shell nanocomposite of FeP@Pt is constructed using Fe(III)-polydopamine (denoted as FeP) as the core and platinum particles (Pt) as the shell. The hybrid structure is further covered with hyaluronic acid (HA) to give the final nanoplatform of FeP@Pt@HA (denoted as FPH). FPH exhibits good biological stability, prolongs blood circulation time, and is simultaneously endowed with tumor-targeting ability. With CD44-mediated endocytosis of HA, FPH can be internalized by cancer cells and activated by the tumor microenvironment (TME). The redox reaction between Fe3+ in FPH and endogenous glutathione (GSH) or/and hydrogen peroxide (H2O2) initiates ferroptosis therapy by promoting GSH exhaustion and •OH generation. Moreover, FPH has excellent photothermal conversion efficiency and can absorb near-infrared laser energy to promote the above catalytic reaction as well as to achieve photothermal therapy (PTT). Ferroptosis therapy and PTT are further accompanied by the catalase activity of Pt nanoshells to accelerate O2 production and the high X-ray attenuation coefficient of Pt for enhanced radiotherapy (RT). Apart from the therapeutic modalities, FPH exhibits dual-modal contrast enhancement in infrared (IR) thermal imaging and computed tomography (CT) imaging, offering potential in imaging-guided cancer therapy. In this article, the nanoplatform can remodel the TME through the production of O2, GSH- and H2O2-depletion, coenhanced PTT, ferroptosis, and RT. This multimodal nanoplatform is anticipated to shed light on the design of TME-activatable materials to enhance the synergism of treatment results and enable the establishment of efficient nanomedicine.

Manganese‐Based Immunomodulatory Nanocomposite with Catalase‐Like Activity and Microwave‐Enhanced ROS Elimination Ability for Efficient Rheumatoid Arthritis Therapy

“…The fluorescent probe [Ru(dpp) 3 ]Cl 2 (RDPP, dpp = 4,7‐diphenyl‐1,10‐phenanthroline), when co‐incubated with oxygen‐depleted cells, shows red fluorescence and is quenched as the intracellular O 2 content increases. [ 67 ] As shown in Figure 4b,c, it could be observed that the red fluorescence of RDPP in the LPS‐induced RAW 264.7 cells was very bright, indicating very low O 2 content. The hypoxia state could hardly be alleviated under exclusively MW irradiation (3 W, 450 MHz, 5 min).…”

“…The fluorescent probe [Ru(dpp) 3 ]Cl 2 (RDPP, dpp = 4,7-diphenyl-1,10-phenanthroline), when co-incubated with oxygen-depleted cells, shows red fluorescence and is quenched as the intracellular O 2 content increases. [67] As shown in Figure 4b,c Many studies have shown that excessive ROS in RA leads to oxidative stress and aggravates the occurrence and development of inflammation. [68] To confirm the ROS elimination capacity of UMnEH, we used 2′,7′-dichlorodihydrofluorescein diacetate (DCFH-DA) as a probe to monitor the ROS level in the LPSinduced RAW 264.7 cells.…”

Hydrazide/Metal/Indocyanine Green Coordinated Nanoplatform for Potentiating Reciprocal Ferroptosis and Immunity against Melanoma

“…Hence, developing a Cu/Fe bimetal-based Fenton reagent is highly desired to induce efficient Ferroptosis. On the other hand, eliminating intracellular reactive oxygen species (ROS)-scavenging substances like GSH is necessary to avoid the brake on Ferroptosis. , However, the integration of these two functions into one nanoplatform is still challenging.…”

One-Step Synthesis of Self-Stratification Core-Shell Latex for Antimicrobial Coating

“…Changing the layer thickness of the core-shell structures or the contents of other materials in the layers can also produce many excellent properties, giving them a wide range of applications [ 30 , 32 ]. For example, in the field of biomedicine, core-shell nanoparticles are mainly used for controlled drug transport [ 33 ], the imaging of organisms, cellular labeling [ 34 ], biosensors [ 35 ], and regenerative medicine [ 36 ]. Through scientific design, it is possible to obtain core-shell and variously shaped structures, including strawberry-type [ 37 ], snowman-type, and island-type [ 38 ].…”