Remote Control of T Cell Activation Using Magnetic Janus Particles

Lee, Kwahun; Yi, Yi; Yu, Yan

doi:10.1002/anie.201601211

Cited by 62 publications

(48 citation statements)

References 34 publications

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“…In 2003, June and co‐workers studied various means for conjugating molecules to magnetic aAPCs and studied the role of molecule surface concentration to promote antigen‐specific T cell activation . While much work has been devoted to the instantaneous induction of T cells, Yu and co‐workers developed a magnetic Janus particle that temporally regulates T cell induction via magnetically induced particle rotation . Finally, in 2014, Fahmy and co‐workers developed a composite aAPC made from bundled CNTs and magnetite encased in PLGA microspheres for displaying OVA and releasing IL‐2 to treat melanoma ( Figure ) .…”

Section: Microscale Materials For Immunotherapymentioning

confidence: 99%

“…[411] While much work has been devoted to the instantaneous induction of T cells, Yu and co-workers developed a magnetic Janus particle that temporally regulates T cell induction via magnetically induced particle rotation. [412] Finally, in 2014, Fahmy and co-workers developed a composite aAPC made from bundled CNTs and magnetite encased in PLGA microspheres for displaying OVA and releasing IL-2 to treat melanoma (Figure 15). [413] While magnetic approaches enable a facile way to simultaneously select for specific cells and drive their induction, one limitation is their rigidity, which similar to polystyrene, is nonideal for optimized T cell induction and expansion.…”

Section: Magnetic Aapcsmentioning

confidence: 99%

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Materials for Immunotherapy

et al. 2019

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Breakthroughs in materials engineering have accelerated the progress of immunotherapy in preclinical studies. The interplay of chemistry and materials has resulted in improved loading, targeting, and release of immunomodulatory agents. An overview of the materials that are used to enable or improve the success of immunotherapies in preclinical studies is presented, from immunosuppressive to proinflammatory strategies, with particular emphasis on technologies poised for clinical translation. The materials are organized based on their characteristic length scale, whereby the enabling feature of each technology is organized by the structure of that material. For example, the mechanisms by which i) nanoscale materials can improve targeting and infiltration of immunomodulatory payloads into tissues and cells, ii) microscale materials can facilitate cell‐mediated transport and serve as artificial antigen‐presenting cells, and iii) macroscale materials can form the basis of artificial microenvironments to promote cell infiltration and reprogramming are discussed. As a step toward establishing a set of design rules for future immunotherapies, materials that intrinsically activate or suppress the immune system are reviewed. Finally, a brief outlook on the trajectory of these systems and how they may be improved to address unsolved challenges in cancer, infectious diseases, and autoimmunity is presented.

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Section: Microscale Materials For Immunotherapymentioning

confidence: 99%

Section: Magnetic Aapcsmentioning

confidence: 99%

Materials for Immunotherapy

et al. 2019

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“…aAPCs may also contain superparamagnetic parts for further separation from cells by the magnetic field. Yu and co-workers [182] designed a magnetic Janus microparticle to remotely control T-cell activation. [179][180][181] For example, a carbon-nanotube-polymer composite (CNP) was developed as an aAPC to efficiently expand T cells isolated from mice (Figure 11).…”

Section: Engineering Dcsmentioning

confidence: 99%

Tailoring Biomaterials for Cancer Immunotherapy: Emerging Trends and Future Outlook

et al. 2017

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Cancer immunotherapy, as a paradigm shift in cancer treatment, has recently received tremendous attention. The active cancer vaccination, immune checkpoint blockage (ICB) and chimeric antigen receptor (CAR) for T-cell-based adoptive cell transfer are among these developments that have achieved a significant increase in patient survival in clinical trials. Despite these advancements, emerging research at the interdisciplinary interface of cancer biology, immunology, bioengineering, and materials science is important to further enhance the therapeutic benefits and reduce side effects. Here, an overview of the latest studies on engineering biomaterials for the enhancement of anticancer immunity is given, including the perspectives of delivery of immunomodulatory therapeutics, engineering immune cells, and constructing immune-modulating scaffolds. The opportunities and challenges in this field are also discussed.

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“…With the x / y coordinates information, the distance that a particle travelled within 100 ms was determined. The magnetic propulsion was conducted with a home‐made magnetic field generating device . The magnetic device was positioned near the imaging chamber of the microscope stage, and was rotated to provide a rotating magnetic field.…”

Section: Methodsmentioning

confidence: 99%

“…The magnetic propulsion was conducted with a home-made magnetic field generating device. [37] The magnetic device was positioned near the imaging chamber of the microscope stage, and was rotated to provide a rotating magnetic field. The intensity of the applied magnetic field was 50 G at the stage with a rotational speed of 120 rad min −1 .…”

Section: Methodsmentioning

confidence: 99%

Wireless Manipulation of Magnetic/Piezoelectric Micromotors for Precise Neural Stem‐Like Cell Stimulation

Liu

Chen

Liu

et al. 2020

Adv Funct Materials

106

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Precise neural electrical stimulation, which is a means of promoting neuronal regeneration, is a promising solution for patients with neurotrauma and neurodegenerative diseases. In this study, wirelessly controllable targeted motion and precise stimulation at the single‐cell level using S.platensis@Fe3O4@tBaTiO3 micromotors are successfully demonstrated for the first time. A highly versatile and multifunctional biohybrid soft micromotor is fabricated via the integration of S.platensis with magnetic Fe3O4 nanoparticles and piezoelectric BaTiO3 nanoparticles. The results show that this micromotor system can achieve navigation in a highly controllable manner under a low‐strength rotating magnetic field. The as‐developed system can achieve single‐cell targeted motion and then precisely induce the differentiation of the targeted neural stem‐like cell by converting ultrasonic energy to an electrical signal in situ owing to the piezoelectric effect. This new approach toward the high‐precision stimulation of neural stem‐like cells opens up new applications for micromotors and has excellent potential for precise neuronal regenerative therapies.

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Remote Control of T Cell Activation Using Magnetic Janus Particles

Cited by 62 publications

References 34 publications

Materials for Immunotherapy

Materials for Immunotherapy

Tailoring Biomaterials for Cancer Immunotherapy: Emerging Trends and Future Outlook

Wireless Manipulation of Magnetic/Piezoelectric Micromotors for Precise Neural Stem‐Like Cell Stimulation

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