Remote electronic control of DNA hybridization through inductive coupling to an attached metal nanocrystal antenna

Hamad‐Schifferli, Kimberly; Schwartz, John J.; Santos, Aaron; Zhang, Shuguang; Jacobson, Joseph M.

doi:10.1038/415152a

Cited by 368 publications

(290 citation statements)

References 26 publications

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“…In a similar approach, which is less related to sensors but shows the capability of DNA-nanoparticle structures, a remote electronic control of DNA hybridization has been demonstrated recently by Hamad-Schifferli et al (164). Inductive coupling of a radio-frequency magnetic field to a metal nanoparticle, which is covalently linked to DNA, increases the local temperature of the bound DNA, thereby inducing denaturation while leaving the surrounding molecules relatively unaffected.…”

Section: Applications Of Metal Nanoparticles As Sensorsmentioning

confidence: 99%

Optical Properties and Ultrafast Dynamics of Metallic Nanocrystals

Link¹,

El‐Sayed

2003

Annu. Rev. Phys. Chem.

1,531

1,499

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Noble metal particles have long fascinated scientists because of their intense color, which led to their application in stained glass windows as early as the Middle Ages. The recent resurrection of colloidal and cluster chemistry has brought about the strive for new materials that allow a bottoms-up approach of building improved and new devices with nanoparticles or artificial atoms. In this review, we discuss some of the properties of individual and some assembled metallic nanoparticles with a focus on their interaction with cw and pulsed laser light of different energies. The potential application of the plasmon resonance as sensors is discussed.

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Section: Applications Of Metal Nanoparticles As Sensorsmentioning

confidence: 99%

Optical Properties and Ultrafast Dynamics of Metallic Nanocrystals

Link¹,

El‐Sayed

2003

Annu. Rev. Phys. Chem.

1,531

1,499

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“…Similarly, other metal and semiconductor nanoclusters may be attached to the coiled-coil peptide to build a nanowire for potential control through radio frequency-magnetic field. 35 Using the designed coiled-coil peptides and other molecular materials to build nanomaterials, for which the selfassembly process can be controlled by common biochemical methods, is a novel approach to achieve multiple length scales simultaneously. It is hoped that our work reported here may stimulate additional research to produce new materials.…”

Section: -16mentioning

confidence: 99%

Hierarchical Self-Assembly of a Coiled-Coil Peptide into Fractal Structure

2005

Self Cite

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Here we report the hierarchical self-assembly of a cross-linkable coiled-coil peptide containing an internal cysteine. Atomic force microscopy (AFM) experiments revealed the fractal structure of the assemblies, and molecular simulations showed that the peptides cross-linked to form clusters of coiled-coils, which further assembled to form globules of tens of nanometers in diameter. Such hierarchical organization was modulated by pH or thiol-reducing agent. Exploitation of the fractal structures through chemical methods may be valuable for the fabrication of materials spanning multiple length scales.There is a growing interest and continuous demand in the fabrication of smaller and smaller materials, parts, and features for nanotechnology and nanobiotechnology. One of the most difficult tasks is to produce materials that incorporate multiple length scales simultaneously, from nano and micro, to macro scales. Fractals achieve this goal because of their self-similarity, as demonstrated not only mathematically 1,2 but also in the real world; their uses in biology, chemistry, physics, and engineering are exemplified by numerous observations and computer simulations.3-10 Therefore, fabrication of fractal structures can be an alternative way to fabricate advanced materials for a broad range of applications.Fabrication of fractal nanomaterials requires self-assembly since direct manipulation of such self-similar structures at the lower end of the scale is extremely difficult to achieve. Self-assembly of biomolecules has recently emerged as an alternative fabrication method for a variety of material processing, from a few nanometers to a macroscopic scale. 11,12 An emerging field of molecular self-assembly of biological materials can be combined with traditional material processing, melting/solidification, solution processes, and vacuum deposition, so that novel materials can be designed and fabricated. Molecular self-assembly takes place via a subtle balance between noncovalent interactions such as electrostatic and hydrophobic interactions that result in the formation of well-defined structures. 11-16We have previously reported the discovery and design of several classes of self-assembling peptides to produce various nanostructures.12 One example is the formation of a lefthanded helical ribbon of uniform geometry through the selfassembly of a -sheet forming peptide. 17 Another example is the self-assembly of peptide surfactants into nanotubes and nanovesicles. [18][19][20] Others have used peptide self-assembly to form scaffolds on which various nanostructured organic or inorganic materials are produced. [13][14][15] One of the key challenges in the fabrication of new materials via such bottom-up technology is the organization of nanostructures across a wide spectrum of length scales. 11-16Here we report the formation of fractal structures from a self-assembling coiled-coil peptide. We introduced a cysteine at the N-terminus of the peptide sequence and studied its self-assembly behaviors. The self-assembly of t...

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“…Most biomacromolecules were extensively characterized in aqueous environments, but in TLC phases, their solvent-free properties and functions could be investigated in a state in which no or only traces of water are present. Water exhibits a high dielectric constant and has the ability to form hydrogen bonds, greatly influencing the structure and functions of biomacromolecules or compromising electronic properties such as charge transport (12)(13)(14)(15). Indeed, anhydrous TLC systems containing glycolipids (16)(17)(18)(19), ferritin (20), and polylysine have been reported (21)(22)(23).…”

mentioning

confidence: 99%

Thermotropic liquid crystals from biomacromolecules

Li¹,

Chen

Marcozzi³

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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Complexation of biomacromolecules (e.g., nucleic acids, proteins, or viruses) with surfactants containing flexible alkyl tails, followed by dehydration, is shown to be a simple generic method for the production of thermotropic liquid crystals. The anhydrous smectic phases that result exhibit biomacromolecular sublayers intercalated between aliphatic hydrocarbon sublayers at or near room temperature. Both this and low transition temperatures to other phases enable the study and application of thermotropic liquid crystal phase behavior without thermal degradation of the biomolecular components.L iquid crystals (LCs) play an important role in biology because their essential characteristic, the combination of order and mobility, is a basic requirement for self-organization and structure formation in living systems (1-3). Thus, it is not surprising that the study of LCs emerged as a scientific discipline in part from biology and from the study of myelin figures, lipids, and cell membranes (4). These and the LC phases formed from many other biomolecules, including nucleic acids (5, 6), proteins (7,8), and viruses (9, 10), are classified as lyotropic, the general term applied to LC structures formed in water and stabilized by the distinctly biological theme of amphiphilic partitioning of hydrophilic and hydrophobic molecular components into separate domains. However, the principal thrust and achievement of the study of LCs has been in the science and application of thermotropic materials, structures, and phases in which molecules that are only weakly amphiphilic exhibit LC ordering by virtue of their steric molecular shape, flexibility, and/or weak intermolecular interactions [e.g., van der Waals and dipolar forces (11)]. These characteristics enable thermotropic LCs (TLCs) to adopt a wide variety of exotic phases and to exhibit dramatic and useful responses to external forces, including, for example, the electro-optic effects that have led to LC displays and the portable computing revolution. This general distinction between lyotropic LCs and TLCs suggests there may be interesting possibilities in the development of biomolecular or bioinspired LC systems in which the importance of amphiphilicity is reduced and the LC phases obtained are more thermotropic in nature. Such biological TLC materials are very appealing for several reasons. Most biomacromolecules were extensively characterized in aqueous environments, but in TLC phases, their solvent-free properties and functions could be investigated in a state in which no or only traces of water are present. Water exhibits a high dielectric constant and has the ability to form hydrogen bonds, greatly influencing the structure and functions of biomacromolecules or compromising electronic properties such as charge transport (12-15). Indeed, anhydrous TLC systems containing glycolipids (16-19), ferritin (20), and polylysine have been reported (21-23). However, a general approach to fabricating TLCs based on nucleic acids, polypeptides, proteins, and protein assemblies of larg...

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Remote electronic control of DNA hybridization through inductive coupling to an attached metal nanocrystal antenna

Cited by 368 publications

References 26 publications

Optical Properties and Ultrafast Dynamics of Metallic Nanocrystals

Optical Properties and Ultrafast Dynamics of Metallic Nanocrystals

Hierarchical Self-Assembly of a Coiled-Coil Peptide into Fractal Structure

Thermotropic liquid crystals from biomacromolecules

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